Delving into the Latest Updates on Doxorubicin Hydrochloride liposomal(Accord) with Synapse

Overview

Basic Info

Drug Type

Small molecule drug, Liposomal Drug

Synonyms

Zolsketil pegylated liposomal

Target

Top II

Action

inhibitors

Mechanism

Top II inhibitors(Topoisomerase II inhibitors)

Therapeutic Areas

NeoplasmsImmune System DiseasesInfectious Diseases+ [5]

Active Indication

Inactive Indication-

Originator Organization

Accord Healthcare SLU

Active Organization

Accord Healthcare SLU

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

European Union (31 May 2022),

Regulation-

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High heterogeneity of hepatocellular carcinoma (HCC) tumor has become an obstacle to select effective therapy for the treatment of HCC patients. Methods that can guide the decision on therapy choice for HCC treatment are highly demanded. Evaluating the drug response of heterogeneous tumor cells at the molecular level can help to reveal the toxicity mechanism of anticancer drugs and provide more information than current cell-based chemosensitivity assays. In the present work, nanostructure-assisted laser desorption/ionization mass spectrometry (NALDI-MS) was used to investigate the lipid response of HCC cells to anticancer drugs. Three types of HCC cells (LM3, Hep G2, Huh7) were treated with sorafenib, doxorubicin hydro-chloride, and cisplatin. We found that the lipid profiles of HCC cells changed a lot after the drug treatment, and the degree of lipid changes was related to the cell viability. Two pairs of fatty acids C16:1/C16:0 and C18:1/C18:0 were found to be strongly related to the viability of HCC cells after drug treatment, and were more sensitive than Methyl-thiazolyl tetrazolium (MTT) assay. Accordingly, they can act as sensitive and comprehensive indexes to evaluate the drug susceptibility of HCC cells. In addition, the peak ratio of several neighboring phospholipids displayed high correlation with drug response of specific cell subtype to specific drug. The ratio of neighboring lipids may be traced back to the activity of enzyme and gene expression which regulate the lipidomic pathway. This method provides drug response of heterogenous tumor cells at molecular level and could be a potential candidate to precise tumor chemosensitivity assay.

100 Deals associated with Doxorubicin Hydrochloride liposomal(Accord)

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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
AIDS-related Kaposi Sarcoma	Norway	Accord Healthcare SLU	31 May 2022
AIDS-related Kaposi Sarcoma	European Union	Accord Healthcare SLU	31 May 2022
AIDS-related Kaposi Sarcoma	Liechtenstein	Accord Healthcare SLU	31 May 2022
AIDS-related Kaposi Sarcoma	Iceland	Accord Healthcare SLU	31 May 2022
Breast Cancer	Iceland	Accord Healthcare SLU	31 May 2022
Breast Cancer	European Union	Accord Healthcare SLU	31 May 2022
Breast Cancer	Norway	Accord Healthcare SLU	31 May 2022
Breast Cancer	Liechtenstein	Accord Healthcare SLU	31 May 2022
Multiple Myeloma	Iceland	Accord Healthcare SLU	31 May 2022
Multiple Myeloma	Norway	Accord Healthcare SLU	31 May 2022
Multiple Myeloma	European Union	Accord Healthcare SLU	31 May 2022
Multiple Myeloma	Liechtenstein	Accord Healthcare SLU	31 May 2022
Ovarian Cancer	European Union	Accord Healthcare SLU	31 May 2022
Ovarian Cancer	Liechtenstein	Accord Healthcare SLU	31 May 2022
Ovarian Cancer	Iceland	Accord Healthcare SLU	31 May 2022
Ovarian Cancer	Norway	Accord Healthcare SLU	31 May 2022