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Last update 20 Mar 2025

Sulfathiazole

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

2-(Sulfanilylamino)thiazole, 2-(p-Aminobenzenesulfonamido)thiazole, 2-(p-Aminobenzenesulphonamido)thiazole

+ [14]

Target

DHPS

Action

inhibitors

Mechanism

DHPS inhibitors(Dihydropteroate synthase inhibitors)

Therapeutic Areas

Infectious DiseasesSkin and Musculoskeletal DiseasesUrogenital Diseases

Active Indication

Bacterial VaginosisSkin Diseases, Infectious

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC9H9N3O2S2

InChIKeyJNMRHUJNCSQMMB-UHFFFAOYSA-N

CAS Registry72-14-0

100 Clinical Results associated with Sulfathiazole

100 Translational Medicine associated with Sulfathiazole

100 Patents (Medical) associated with Sulfathiazole

7,718

Literatures (Medical) associated with Sulfathiazole

01 Jul 2025·Separation and Purification Technology

Hydroquinone enhanced Cu(II)/peroxymonosulfate for the degradation of sulfonamide antibiotics under acidic pH conditions

Author: Lv, Xiaoli ; Huang, Xianfeng ; Xiao, Jibo ; Cai, Anhong ; Wang, Tianhong ; Zhao, Min ; Zhang, Hui

The Cu(II)-mediated activation of peroxymonosulfate (PMS) has been studied for the degradation of contaminants due to its ability to produce reactive species.However, the yield of reactive species generated from Cu(II)/PMS is relatively low under acidic conditions due to the slow conversion rate of metal valence states, which limits its application prospects.Herein, we found that the introduction of hydroquinone (HQ) in the Cu(II)/PMS system can accelerate the activation of PMS by promoting the redox cycling of Cu(II)/Cu(I), thereby achieving efficient destruct of sulfonamide antibiotics.The degradation rate constants of six sulfonamide antibiotics by HQ/Cu(II)/PMS system was 5-8 times of that by Cu(II)/PMS system under pH 3.0.Both hydroxyl radical (HO.) and singlet oxygen (1O₂) participated in the degradation of sulfamethoxazole (SMX, a representative sulfonamide antibiotic), and the former played the most important role.HQ improved the reduction of Cu(II) to Cu(I) due to the electron-donating capacity of hydroxyl in HQ, thereby promoting PMS decomposition to produce more HO. under acidic conditions.The presence of humic acid (HA) and low concentration of Cl^- presented the inhibitory effect on SMX degradation, while the degradation of SMX was promoted in the presence of high concentration of Cl^-.The addition of NO₃^- and SO₄^2- has almost no effect on the removal of SMX.The degradation pathways of SMX by HQ/Cu(II)/PMS system mainly involved in the S-N cleavage and amino oxidationThe significant enhancement effects were still observed in actual wastewater treatment by Cu(II)/PMS system after introduction of HQ.

01 Jun 2025·Separation and Purification Technology

Thiol-yne click postsynthesis of imidazole-functionalized cyclodextrin microporous organic network: A remarkable adsorbent for sulfonamide antibiotics

Author: Yang, Cheng-Xiong ; Wang, Ting ; Yue, Yun-Da ; Cui, Yuan-Yuan

Sulfonamides (SAs) are widely used broad-spectrum antibiotics for treating infections.However, their inevitable residues pose serious threats to human health and agroecosystems.Hence, reasonable design and synthesis efficient adsorbents to remove residual SAs from the environment are crucial and highly desired.In this study, a novel imidazole-functionalized cyclodextrin-based microporous organic network (α-CD-MON-BZ) was designed and synthesized through the specific thiol-yne click post-modification for the efficient removal of SAs.The prepared α-CD-MON-BZ exhibited ultrafast adsorption kinetics (<3 min) and an exceptionally high saturation adsorption capacity (571.4 mg/g) for sulfamethoxypyridazine (SMP).This capacity was much higher than those of other reported adsorbents.Fourier transform IR spectroscopy, XPS, and d. functional theory calculations revealed that the adsorption process involves hydrophobic, π-π, hydrogen bonding, host-guest, and electrostatic interactions.Furthermore, α-CD-MON-BZ exhibited favorable reusability and selectivity.This study introduces a new method to construct novel functionalized CD-MONs for highly efficient SAs removal and promotes the design and applications of such materials in contaminant removal.

01 Apr 2025·Molecular Diversity

Synthesis, molecular docking and molecular dynamics simulations, drug-likeness studies, ADMET prediction and biological evaluation of novel pyrazole-carboxamides bearing sulfonamide moiety as potent carbonic anhydrase inhibitors

Article

Author: Tunca, Ekrem ; Kasımoğulları, Rahmi ; Yetek, İrfan ; Mert, Samet ; Bayrakdar, Alpaslan

AbstractPyrazoles are unique bioactive molecules with a versatile biological profile and they have gained an important place on pharmaceutical chemistry. Pyrazole compounds containing sulfonamide nuclei also attract attention as carbonic anhydrase (CA) inhibitors. In this study, a library of pyrazole-carboxamides were synthesized and the structures of the synthesized molecules were characterized using FT-IR, 1H-NMR, 13C-NMR and HRMS. Then the inhibition effects of newly synthesized molecules on human erythrocyte hCA I and hCA II isoenzymes were investigated. Ki values of the compounds were in the range of 0.063–3.368 µM for hCA I and 0.007–4.235 µM for hCA II. Molecular docking studies were performed between the most active compounds 6a, 6b and the reference inhibitor, acetazolamide (AAZ) and the hCA I and hCA II receptors to investigate the binding mechanisms between the compounds and the receptors. These compounds showed better interactions than the AAZ. ADMET analyzes were performed for the compounds and it was seen that the compounds did not show AMES toxicity. The stability of the molecular docking results over time was analysed by 50 ns molecular dynamics simulations. Molecular dynamics simulations revealed that 6a and 6b exhibited good stability after docking to the binding sites of hCA I and hCA II receptors, with minor conformational changes and fluctuations.Graphical abstractSynthesis, molecular docking, molecular dynamics simulations, drug-likeness, ADMET prediction and biological evaluation of pyrazole-carboxamides bearing sulfonamide moiety as potent carbonic anhydrase inhibitors

100 Deals associated with Sulfathiazole

External Link

KEGG	Wiki	ATC	Drug Bank
D01047	Sulfathiazole	J01EB07 D06BA02	DB06147

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Bacterial Vaginosis	-	-	-
Skin Diseases, Infectious	-	-	-

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