In this study, we focused on the successful construction of [(4,4'-bipy/P₂Mo₁₇Co)₆] modified electrodes using the layer-by-layer assembly method for the sensitive detection of sulfathiazole (ST). The redox reaction between ST and the metal ions in the modified layer leads to the transfer of electrons, resulting in the generation of the electrical signal. The introduction of 4,4'-bipyridine (4,4'-bipy) enhanced the molecular recognition of ST by the modified electrode. Under the combined effect of P₂Mo₁₇Co and 4,4'-bipy, the sensor exhibited good performance for ST detection (LOD: 0.5616 μM, linear ST concentration range: 0-50 μM). The spiked recoveries of the two groups were 84.4%-103.2% and 90.9%-109.4% for the determination of ST residues in large yellow croaker and South American white shrimp, respectively. In addition, the electrode showed excellent performance in terms of stability, reproducibility, and anti-interference ability.

01 Dec 2024·Science of The Total Environment

Degradation of sulfamethoxazole in a falling film dielectric barrier discharge system: Performance, mechanism and toxicity evaluation

Article

Author: Deng, Siyu ; Zhu, Luxiang ; Zhang, Han ; Liu, Yanan

The ubiquitous presence of sulfonamides (SAs) in wastewater poses serious risks to human health and ecosystem safety. This study evaluated the performance of a falling film dielectric barrier discharge (DBD) system on the removal of five SAs, namely sulfamethoxazole (SMX), sulfisoxazole (SIZ), sulfathiazole (STZ), sulfadiazine (SDZ) and sulfamerazine (SMR). Removal efficiencies >99 % were observed for all target SAs within 30 min of treatment, with pseudo-first order rate constants varying between 0.17 and 0.27 min^-1. Superior removal efficiencies were achieved under acidic conditions compared to neutral and alkaline conditions. Using SMX as a model compound, mechanistic investigations revealed that the synergy of reactive oxygen species (ROS) and reactive nitrogen species (RNS) led to its efficient degradation, with peroxynitrites (ONOO^-/ONOOH) and hydroxyl radical (OH) playing pivotal roles. SMX degradation pathways encompassing nitration/nitrosation, hydroxylation, deamination, CS and SN bond cleavage were proposed. The toxicity evaluation results demonstrated that the solution toxicity diminished following the plasma treatment under specific conditions. In particular, the solution treated with air or oxygen discharge enhanced the growth of wheat seedlings, suggesting the potential for reusing plasma-treated wastewater in agriculture. This study enhances our understanding of the underlying mechanisms involved in the plasma degradation of SAs and reveals the significant potential of plasma technology as a sustainable approach for treating wastewater.

01 Dec 2024·Journal of Hazardous Materials

Molecular insights into biological transformation mechanism of sulfathiazole by Chlorella sorokiniana: Deciphering the uptake, translocation, and biotransformation

Article

Author: Chen, Xi ; Xie, Peng ; Li, Shengnan ; Chu, Yuhao ; Li, Xue ; Ho, Shih-Hsin

As a sustainable approach to wastewater treatment, microalgae have been extensively used to degrade antibiotics. However, the underlying mechanisms involved in the degradation process remain unclear. Therefore, this study investigated the biotransformation mechanism of sulfathiazole (STZ) by Chlorella sorokiniana (C. sorokiniana) at the molecular level. The results show that C. sorokiniana could efficiently degrade STZ, achieving a maximum degradation rate of 94.74 %, mainly through biodegradation routes. Transcriptome analysis has elucidated the potential biological transformation mechanisms driving the degradation of STZ by microalgae, focusing on the uptake, translocation, and biotransformation as key metabolic processes. In particular, STZ induced the up-regulation of genes associated with cell adhesion, membrane protein, and lipopolysaccharide, suggesting their involvement in the uptake of STZ by microalgae. Furthermore, ABC, MATE, and MFS transporters were identified as crucial for the transmembrane transport of STZ by microalgae. A plausible biotransformation pathway for STZ degradation was proposed, identifying hydroxylation, oxidation, ring cleavage, and formylation as the primary transformation processes. The up-regulation of key enzymes such as monooxygenases, dioxygenases, hydrolases, and transferases suggested their pivotal role in the biodegradation of STZ. This research provides valuable insights into the biotransformation mechanisms of STZ by microalgae, thereby laying a theoretical framework to advance the implementation of microalgae in the treatment of antibiotic-contaminated wastewater.

100 Deals associated with Sulfathiazole

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KEGG	Wiki	ATC	Drug Bank
D01047	Sulfathiazole	J01EB07 D06BA02	DB06147

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Indication	Country/Location	Organization	Date
Bacterial Vaginosis	-	-	-
Skin Diseases, Infectious	-	-	-

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