Delving into the Latest Updates on Fibrin glue(Foundation For Biomedical Research And Innovation) with Synapse

Overview

Basic Info

Drug Type

Non-recombinant coagulation factor

Synonyms

Target

Fibrinogen

Mechanism

Fibrinogen stimulants

Therapeutic Areas

Otorhinolaryngologic DiseasesOther Diseases

Active Indication

Tympanic Membrane Perforation

Inactive Indication-

Originator Organization

Foundation For Biomedical Research And Innovation

Active Organization

Foundation For Biomedical Research And Innovation

Inactive Organization-

Drug Highest PhasePhase 3

First Approval Date-

Regulation-

Background: Split-thickness skin grafts (STSGs) remain a valuable tool in the reconstructive surgeons’ armamentarium. Staple or suture mechanical fixation (MF) serves as the gold standard of care, though fibrin glue (FG) has gained popularity as a fixation modality. We compare STSG outcomes following application of FG versus MF through a study of lower extremity wounds. Methods: A retrospective review (2016-2019) of patients who underwent a STSG was performed. Two cohorts consisting of patients undergoing a STSG with FG or MF (suture or staple) were matched according to wound size, wound location, and body mass index. Results: A total of 67 patients with 79 wounds were included (FG: n = 30, wounds = 39; MF: n = 37; wounds = 40). There was no significant difference between groups regarding time to 100% graft take (FG: 39 days, MF: 35.1 days; P < .384) or 180-day graft complications (FG: 10.3%, MF: 15%; P < .737). Adjusted operative time for FG (51.8 min) was lower than for MF cases (67.5 min) at a level that approached significance ( P < .094). FG patients were significantly less likely to require a postoperative wound vacuum-assisted closure (VAC) (FG: 16.7%; MF: 76.7%; P < .001) and required a significantly lower number of 30-day postoperative visits (FG: 1.5 ± .78 visits; MF: 2.5 ± .03 visits; P < .001). The MF group had higher mean aggregate charges ($211,090) compared with the FG group (mean: $149,907), although these were not statistically significant ( P > .05). Conclusion: The use of FG for STSG shows comparable clinical outcomes to MF, with a significantly decreased need for postoperative wound VAC, the number of 30-day postoperative visits, and a lower wound-adjusted operative time.

01 May 2024·International Journal of Biological Macromolecules

Therapeutic applications of biological macromolecules and scaffolds for skeletal muscle regeneration: A review

Review

Author: Ahmad, Syed Sayeed ; Shaikh, Sibhghatulla ; Ahmad, Khurshid ; Lee, Eun Ju ; Lim, Jeong Ho ; Choi, Inho

Skeletal muscle (SM) mass and strength maintenance are important requirements for human well-being. SM regeneration to repair minor injuries depends upon the myogenic activities of muscle satellite (stem) cells. However, losses of regenerative properties following volumetric muscle loss or severe trauma or due to congenital muscular abnormalities are not self-restorable, and thus, these conditions have major healthcare implications and pose clinical challenges. In this context, tissue engineering based on different types of biomaterials and scaffolds provides an encouraging means of structural and functional SM reconstruction. In particular, biomimetic (able to transmit biological signals) and several porous scaffolds are rapidly evolving. Several biological macromolecules/biomaterials (collagen, gelatin, alginate, chitosan, and fibrin etc.) are being widely used for SM regeneration. However, available alternatives for SM regeneration must be redesigned to make them more user-friendly and economically feasible with longer shelf lives. This review aimed to explore the biological aspects of SM regeneration and the roles played by several biological macromolecules and scaffolds in SM regeneration in cases of volumetric muscle loss.

100 Deals associated with Fibrin glue(Foundation For Biomedical Research And Innovation)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Tympanic Membrane Perforation	Phase 3	-	Foundation For Biomedical Research And Innovation	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ARVO2015	Not Applicable	Pterygium	99	Conjunctival autograft (CA) with fibrin glue alone	(flocamlhav) = jilmnqbbrj jifupkwlyq (wvcblhbhoe )	-	01 Jun 2015
PO337 (AAO2019)	Not Applicable	Strabismus	-	Hang-back recession with fibrin glue	(qmvjlleihe) = no complications beyumzgebt (uwivakshdp ) View more	Positive	12 Oct 2019
ARVO2002	Not Applicable	Blister	20	Cultured skin + Fibrin glue	(nmujvqnbxn) = zofalgmfrv lcydftjmtm (lwuhgzxkwt )	Positive	01 Dec 2002
ARVO2002	Not Applicable	Blister	20	Free Electron Laser-treated Fibrin Glue	(nmujvqnbxn) = rjahmmulok lcydftjmtm (lwuhgzxkwt )	Positive	01 Dec 2002
P291 (EBMT2018)	Not Applicable	Hemorrhagic cystitis	63	Fibrin-glue	(ylkiocbpkc) = mfrzlvlqhq zgqmjmeyzt (oabvdojzal ) View more	-	19 Nov 2018
ARVO2015	Not Applicable	Pterygium	-	AMG with fibrin glue	zknwywxjiq(cwxeemmsyv) = xvlfwhoqtv jwkkloxopy (jhhdtlogoe )	Positive	01 Jun 2015
AAO2013	Not Applicable	-	23	Fibrin glue-assisted intrascleral fixation of PC-IOL	(tfbaxjfvlb) = imcnuoactc nmltqifxnh (scrcspqaeg ) View more	Positive	17 Nov 2013
Pubmed	Not Applicable	Hemorrhage	254	Fibrin Glue (Control group)	(kihzxskloc) = horynvtwmf vgrofygqao (knipihfacy ) View more	-	30 Dec 2022
Pubmed	Not Applicable	Hemorrhage	254	Fibrin glue group	(kihzxskloc) = cunlhexntv vgrofygqao (knipihfacy ) View more	-	30 Dec 2022
AHNS2012	Not Applicable	-	54	Fibrin glue without suction drainage	(snfhcaeqbg) = wssipakcal wamlorpslk (gnjvvjkzcf )	-	23 Jul 2012
AHNS2012	Not Applicable	-	54	fibrin glue (Conventional surgery with suction drainage)	(snfhcaeqbg) = vtdzlhwsga wamlorpslk (gnjvvjkzcf )	-	23 Jul 2012
PO460 (AAO2006)	Not Applicable	-	16	Amniotic membrane transplantation with fibrin glue	(rphzpqeehq) = granuloma cfeqxqsjjz (wfckoxhxse ) View more	-	13 Nov 2006
ARVO2023	Not Applicable	Pterygium	203	Fibrin glue in the OR	(bwrxgbqvll) = lrixzkwvpn ltvrpmrnxv (wmrtazxlzd )	-	01 Jun 2023
ARVO2023	Not Applicable	Pterygium	203	Fibrin glue in the office	(bwrxgbqvll) = fioclereia ltvrpmrnxv (wmrtazxlzd )	-	01 Jun 2023