Last update 28 May 2025

GEN1057

Overview

Basic Info

Drug Type
Bispecific antibody
Synonyms-
Target
DR4 x FAP
Action
agonists, antagonists
Mechanism
DR4 agonists(Tumor necrosis factor receptor superfamily member 10A agonists), FAP antagonists(Fibroblast activation protein alpha antagonists)
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid NeoplasmMetastatic Solid TumorSolid tumor
Inactive Indication-
Originator Organization
Genmab, Inc.
Active Organization
Genmab BVGenmab, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
Login to view timeline

Related

1
Clinical Trials associated with GEN1057
NCT06573294
/ RecruitingPhase 1
A First-In-Human, Open-Label, Dose Escalation Trial to Evaluate the Safety and Antitumor Activity of GEN1057 in Subjects With Malignant Solid Tumors
100 Clinical Results associated with GEN1057
Login to view more data
100 Translational Medicine associated with GEN1057
Login to view more data
100 Patents (Medical) associated with GEN1057
Login to view more data
100 Deals associated with GEN1057
Login to view more data

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1
United States
Genmab, Inc.
28 Aug 2024
Advanced Malignant Solid NeoplasmPhase 1
Japan
Genmab, Inc.
28 Aug 2024
Advanced Malignant Solid NeoplasmPhase 1
Spain
Genmab, Inc.
28 Aug 2024
Metastatic Solid TumorPhase 1
United States
Genmab, Inc.
28 Aug 2024
Metastatic Solid TumorPhase 1
Japan
Genmab, Inc.
28 Aug 2024
Metastatic Solid TumorPhase 1
Spain
Genmab, Inc.
28 Aug 2024
Solid tumorPreclinical
Netherlands
Genmab BV
28 Apr 2025
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
login
or
view full example data
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
login
or
view full example data
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
login
or
view full example data
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
login
or
view full example data
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
login
or
view full example data
Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
login
or
view full example data
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

Understand key drug designations in just a few clicks with Synapse.
login
or
view full example data
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free