Delving into the Latest Updates on Creatine Phosphate Sodium with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Creatine phosphate, Creatine phosphic acid, Creatine-P

+ [7]

Target-

Action-

Mechanism-

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Cardiovascular Diseases

Inactive Indication-

Originator Organization-

Active Organization

Alfa Wassermann SpA

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Italy (01 Jan 1992)

Regulation-

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Structure/Sequence

Molecular FormulaC4H10N3O5P

InChIKeyDRBBFCLWYRJSJZ-UHFFFAOYSA-N

CAS Registry67-07-2

View All Structures (2)

Unexpected deaths and unplanned intensive care unit (ICU) admissions are common during hospital stay and are often preceded by warning abnormalities in patients' vital signs. These abnormalities trigger Medical Emergency Team (MET) activation and up to 15% of patients visited by the MET is admitted to the ICU with an overall hospital stay after the MET intervention of approximately 2 weeks. Phosphocreatine (PCr) is a natural energy-buffering molecule associated with signals of mortality reduction in patients with acute cardiac conditions (according to meta-analytic finding from our group) and with encouraging beneficial effects on other acute organ failures (e.g. brain). The investigators designed a multi-center, randomized, placebo-controlled trial to confirm the promising beneficial effects of PCr in hospitalized patients. The investigators expects a reduction in hospital stay (measured as an increase in days alive and out of hospital at 30 days) when PCr is added to standard treatment in patients requiring MET intervention.

Start Date08 Oct 2024

Sponsor / Collaborator

Università Vita-Salute San Raffaele

IRCT20230127057247N1

/ CompletedNot ApplicableIIT

Effects of combined dietary supplementation of protein and creatine on outcomes and acceleration of postoperative recovery in patients with peritrochantic fracture: A double-blind interventional esoteric study

Start Date01 Aug 2023

Sponsor / Collaborator

Tehran University of Medical Sciences

JPRN-UMIN000049691

/ CompletedNot ApplicableIIT

Study on the effect of creatine /ergothioneine supplementation on sperm motility and in vitro fertilization - Study on the effect of creatine /ergothioneine supplementation on sperm motility and in vitro fertilization

Start Date06 Dec 2022

Sponsor / Collaborator-

100 Clinical Results associated with Creatine Phosphate Sodium

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100 Translational Medicine associated with Creatine Phosphate Sodium

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100 Patents (Medical) associated with Creatine Phosphate Sodium

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10,371

Literatures (Medical) associated with Creatine Phosphate Sodium

01 May 2025·Food Control

New approaches towards fish authentication: Pollock and hake differentiation by liquid chromatography high resolution mass spectrometry

Author: Stachniuk, Anna ; Paszkowska, Ewa ; Sumara, Agata ; Kozub-Pedrak, Anna ; Luciuk, Anna ; Wielgosz, Alicja ; Fornal, Emilia ; Montowska, Magdalena

Food adulteration is an important and common problem that can affect public health, safety, and the global economy.Fish is often adulterated by fraudulent activities such as mislabelling the species, substituting lower-quality or cheaper fish for higher-value species, or by adding artificial components to enhance the appearance or weight of the fish product.Here, we demonstrate an untargeted proteomics anal. method using liquid chromatog.-high-resolution mass spectrometry for authenticating fish products.Our research focused on identifying peptide markers for differentiating hake and pollock, two widely consumed high-value fish that are among the most often intentionally substituted and swapped fish species.Twenty-two heat-resistant pollock-specific differentiating peptides and 17 hake-specific differentiating peptides were identified.The applicability of the method was tested using fish fillets and a popular fish product, battered fish fingers.The utility of the method for fish authenticity testing was confirmed.The proposed method can be used in food quality control laboratoriesMoreover, targeted multiple reaction monitoring methods for the identified marker peptides using triple quadrupole mass spectrometry may be developed, which will facilitate and expedite the adoption of this approach by the food industry.

10 Mar 2025·Angewandte Chemie International Edition

Enzymatic Reaction Network‐Driven Polymerization‐Induced Transient Coacervation

Article

Author: Belluati, Andrea ; Kumar, Mohit ; Sharma, Surbhi ; Dhiman, Shikha

AbstractA living cell has a highly complex microenvironment whereas numerous enzyme‐driven processes are active at once. These procedures are incredibly accurate and efficient, although comparable control has not yet been established in vitro. Here, we design an enzymatic reaction network (ERN) that combines antagonistic and orthogonal enzymatic networks to produce adjustable dynamics of ATP‐fueled transient coacervation. Using horseradish peroxidase (HRP)‐mediated Biocatalytic Atom Transfer Radical Polymerization (BioATRP), we synthesized poly(dimethylaminoethyl methacrylate), which subsequently formed coacervates with ATP. We rationally explored enzymatic control over coacervation and dissolution, using orthogonal and antagonistic enzyme pairs viz., alkaline phosphatase, Creatine phosphokinase, hexokinase, esterase, and urease. ATP‐fuelled coacervates also demonstrate the enzymatic catalysis to prove its potential to be exploited as a cellular microreactor. Additionally, we developed ERN‐polymerization‐induced transient coacervation (ERN‐PIC), with complete control over the system, polymerization, coacervation, and dissolution. Notably, the coacervation process itself determines functional properties, as seen in selective cargo uptake. The strategy offers cutting‐edge biomimetic applications, and insights into cellular compartmentalization by bridging the gap between synthetic and biological systems. The development of temporally programmed coacervation is promising for the spatial arrangement of multienzyme cascades, and offers novel ideas on the architecture of artificial cells.

01 Mar 2025·Magnetic Resonance in Medicine

Mitochondrial oxidative phosphorylation capacity in skeletal muscle measured by ultrafast Z‐spectroscopy (UFZ) MRI at 3T

Article

Author: Ju, Licheng ; Ganji, Sandeep ; Schär, Michael ; Samuel, T. Jake ; Wu, Yihan ; Wang, Kexin ; Li, Anna ; van Zijl, Peter C. M. ; Yadav, Nirbhay N. ; Weiss, Robert G. ; Xu, Jiadi

AbstractPurposeTo investigate the feasibility of rapid CEST MRI acquisition for evaluating oxidative phosphorylation (OXPHOS) in human skeletal muscle at 3T, utilizing ultrafast Z‐spectroscopy (UFZ) combined with MRI and the Polynomial and Lorentzian line‐shape Fitting (PLOF) technique.MethodsUFZ MRI on muscle was evaluated with turbo spin echo (TSE) and 3D EPI readouts. Five healthy subjects performed in‐magnet plantar flexion exercise (PFE) and subsequent changes of amide, PCr, and partial PCr mixed Cr (Cr+) CEST dynamic signals post‐exercise were enabled by PLOF fitting. PCr/Cr CEST signal was further refined through pH correction by using the ratios between PCr/Cr and amide signals, named PCAR/CAR, respectively.ResultsUFZ MRI with TSE readout significantly reduces acquisition time, achieving a temporal resolution of <50 s for collecting high‐resolution Z‐spectra. Following PFE, the recovery/decay times (τ) for both PCr and Cr in the gastrocnemius muscle of the calf were notably longer when determined using PCr/Cr CEST compared to those after pH correction with amideCEST, namely = 87.1 ± 15.8 s and = 98.1 ± 20.4 s versus = 32.9 ± 19.7 s and = 43.0 ± 13.0 s, respectively. obtained via 31P MRS ( = 50.3 ± 6.2 s) closely resemble those obtained from pH‐corrected PCr/Cr CEST signals.ConclusionThe outcomes suggest potential of UFZ MRI as a robust tool for non‐invasive assessment of mitochondrial function in skeletal muscles. pH correction is critical for the reliable OXPHOS measurement by CEST.

100 Deals associated with Creatine Phosphate Sodium

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	C01EB	DB13191

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Cardiovascular Diseases	China	Alfa Wassermann SpA	04 Aug 2000

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01502813 (CTgov)	Not Applicable	Cognition	40	Creatine+Citicoline, Omega-3 Fatty Acids	adhhzbgcvh(mlhawnnsod) = osmdfmrhsf tkbdnbqpmd (nhnrdbgxty, capdzckmmg - qwbbibdrsa) View more	-	22 Apr 2021
NCT00449865 (NET-PD LS-1, CTgov)	Phase 3	Parkinson Disease	1,741	placebo (Placebo)	mcupaxndku(acqgdqvvcj) = lfpoynnwmc gocucxnfss (odqtcsobbr, tpheuqmjhk - loiifukslg) View more	-	02 Apr 2015
NCT00449865 (NET-PD LS-1, CTgov)	Phase 3	Parkinson Disease	1,741	creatine (Creatine)	mcupaxndku(acqgdqvvcj) = cgvxyacvsh gocucxnfss (odqtcsobbr, deffrqfajd - uatmylxgyu) View more	-	02 Apr 2015