The Peptide Vaccine Combined with Prior Immunization of a Conventional Diphtheria-Tetanus Toxoid Vaccine Induced AmyloidβBinding Antibodies on Cynomolgus Monkeys and Guinea Pigs

Q3 · MEDICINE

ArticleOA

Author: Chiba, Akiko ; Kanazawa, Yoshito ; Yano, Akira ; Kanda, Akira ; Kashimoto, Yoshinori ; Iigo, Yutaka ; Miwa, Yoshikatsu ; Makino, Mitsuhiro ; Murata, Shinji ; Ito, Kaori

The reduction of brain amyloid beta (Aβ) peptides by anti-Aβantibodies is one of the possible therapies for Alzheimer’s disease. We previously reported that the Aβpeptide vaccine including the T-cell epitope of diphtheria-tetanus combined toxoid (DT) induced anti-Aβantibodies, and the prior immunization with conventional DT vaccine enhanced the immunogenicity of the peptide. Cynomolgus monkeys were given the peptide vaccine subcutaneously in combination with the prior DT vaccination. Vaccination with a similar regimen was also performed on guinea pigs. The peptide vaccine induced anti-Aβantibodies in cynomolgus monkeys and guinea pigs without chemical adjuvants, and excessive immune responses were not observed. Those antibodies could preferentially recognize Aβ40, and Aβ42compared to Aβfibrils. The levels of serum anti-Aβantibodies and plasma Aβpeptides increased in both animals and decreased the brain Aβ40level of guinea pigs. The peptide vaccine could induce a similar binding profile of anti-Aβantibodies in cynomolgus monkeys and guinea pigs. The peptide vaccination could be expected to reduce the brain Aβpeptides and their toxic effects via clearance of Aβpeptides by generated antibodies.

01 Nov 2007·Current Medical Research and OpinionQ4 · MEDICINE

Primary vaccination of adults with reduced antigen-content diphtheria-tetanus-acellular pertussis or dTpa-inactivated poliovirus vaccines compared to diphtheria-tetanus-toxoid vaccines

Q4 · MEDICINE

Article

Author: Floris J P Hoppener ; Bernard Hoet ; Heidi Theeten ; Pierre Van Damme ; Hans Rümke ; Silvia Narejos ; Ramón Vilatimó

OBJECTIVETo evaluate immunogenicity and reactogenicity of primary vaccination with reduced-antigen-content diphtheria-tetanus-acellular pertussis (dTpa) or dTpa-inactivated poliovirus (dTpa-IPV) vaccine compared to diphtheria-tetanus-toxoid vaccines (Td) in adults > or = 40 years of age without diphtheria or tetanus vaccination for 20 years or with an unknown vaccination history.RESEARCH DESIGN AND METHODSDouble-blind, randomized, controlled clinical trial. Primary vaccination with either three doses of dTpa, one dose of dTpa-IPV followed by two doses of Td, or three doses of Td vaccine (control) administered in a 0-1-6-month schedule.MAIN OUTCOME MEASURESBlood samples were collected before commencement and 1 month after each dose. Local and general symptoms were solicited for 15 days after each dose.RESULTSA total of 460 adults were enrolled, of whom over 48% did not have protective antibody concentrations against diphtheria and tetanus. One month after dose 3 > 99% had seroprotective anti-diphtheria and tetanus antibodies. Three doses were required to maximize anti-diphtheria seroprotection rates. A vaccine response to pertussis antigens was observed in > 92% of dTpa and dTpa-IPV recipients after dose 1. One month after dTpa-IPV, > 98.4% had seroprotective anti-polio titres. No statistically significant differences in local or general symptoms between groups were observed.CONCLUSIONSdTpa and dTpa-IPV can provide primary vaccination of adults. Combinations of dTpa or dTpa-IPV can be used to replace Td and provide booster vaccination against pertussis and polio simultaneously with diphtheria and tetanus, even in situations where the primary vaccination history is unknown.

01 Apr 1991·Zhurnal mikrobiologii, epidemiologii i immunobiologii

[The specific prophylaxis of diphtheria in adults with adsorbed DT-m anatoxin].

Article

Author: Il'ina, A N ; Basova, N N ; Markovich, N I ; Koza, N M ; Fel'dblium, I V ; Ivenskikh, V I

The dependence of immune response on commonly observed immunity characteristics prior to immunization has been established on the basis of the study of the kinetics of immune response in adults receiving injections of adsorbed diphtheria-tetanus (DT) toxoid with reduced antigen content, both for routine immunization and on epidemiological indications. The necessity of the practical use of immunological screening for the differentiated approach to the choice of a suitable preparation (adsorbed diphtheria toxoid, adsorbed DT toxoid or adsorbed DT toxoid with reduced antigen content) and immunization schedule for adults, especially in epidemic foci, has been substantiated.

100 Deals associated with Adsorbed Diphtheria-tetanus Combined Toxoid(Biken Techno Corp.)

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Indication	Country/Location	Organization	Date
Diphtheria	JP	Research Fdn for Microbial Diseases of Osaka University	27 Jul 2006
Diphtheria	JP	Biken Techno Corp.	27 Jul 2006
Tetanus	JP	Research Fdn for Microbial Diseases of Osaka University	27 Jul 2006
Tetanus	JP	Biken Techno Corp.	27 Jul 2006

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