Myc-102

A method for the synthesis of the title compounds [i.e., [(arylmethylene)amino]uracil salts, 5-[(arylmethylene)amino]-2,4(1H,3H)-pyrimidinedione imine derivatives] is reported here.In continuation of studies on the design of new 5-[(arylidene)amino]uracil derivatives possessing antimicrobial and antiviral properties, the corresponding ammonium and sodium salts were synthesized.The antimicrobial activity of water-soluble salts of substituted (amino)uracil derivatives in vitro was shown to be several times higher than that of the parent neutral compoundsThe title compounds thus prepared were screened against Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus niger and a Mycobacterium smegmatis.