Zinc Acexamate

Metabolic syndrome is on the verge of becoming a global epidemic. It is a complex, chronic illness that has epidemic proportions in most industrialized nations. This study examines the antioxidant potential of a sacred plant, the bodhi tree (Ficus religiosa). The capability of F. religiosa to suppress nitric oxide (NO) production and enhance catalase activity was determined using colorimetry methods. Additionally, liquid chromatography-mass spectroscopy was used to determine the phytochemical profile of the plant. The contribution of detected compounds was predicted using activity spectra for biologically active substances online. This study revealed the activity of F. religiosa to suppress NO production with IC50 value was 63.57?g/mL. The activity of F. religiosa to increase the catalase activity did not follow the increase of extract concentration, in contrast with the NO test. The concentration with optimum activity was 10 ?g/mL. The extract can increase catalase activity by 45.45% in this concentration. The presence of corchorifatty acid F, D-(-)-Quinic acid, 2,5-dihydroxybenzaldehyde and gentisic acid, confirmed by LC-MS/MS, might contribute to the antioxidant activity of F. religiosa. In summary, the antioxidant activity of F. religiosa was mediated by NO production suppression and catalase activity enhancement.

Decarboxylative deuteration of activated precursors (e.g., α-amino acids) is an effective method for installing deuterium atoms at activated positions; however, direct usage of unactivated aliphatic carboxylic acids remains a long-standing challenge for the construction of C(sp³)-D bonds at non-activated positions.Herein, we report a general and efficient photoinduced direct deuterodecarboxylation of free aliphatic carboxylic acids via synergistic acridine and thiophenol catalyst systems with D₂O as the cost-effective deuterium source, achieving precise installation of a deuterium atom at non-activated positions.The present methodol. features broad functional group tolerance and displays high chemoselectivity, enabling the late-stage deuteration of natural products and pharmaceuticals, with high levels of D-incorporation (up to 90 examples, up to 99% D).Moreover, a 50 mmol scale-up reaction in the continuous flow process has been demonstrated without loss of D-incorporation and greatly improves the production efficiency with a shortened reaction time from 12 h to 15 min.