Delving into the Latest Updates on Lactobacillus plantarum TCI507 with Synapse

Overview

Basic Info

Drug Type

Probiotics

Synonyms

oranges peels Extract, probiotic extracted from the oranges peels

Target-

Action

modulators

Mechanism

Bacteria replacements, Microbiome modulators

Therapeutic Areas

Other Diseases

Active Indication

Weight Loss

Inactive Indication-

Originator Organization

National Taiwan University Hospital

Active Organization

TCI Co., Ltd.

Inactive Organization-

Drug Highest PhaseClinical

First Approval Date-

Regulation-

Obesity is a serious global public health issue. Many reports have showed that the use of appropriate probiotics can bring benefits to the health of the host and promote the balance of gut microbiota. Clinical experimental data show that the supplement of probiotics can help regulate gut function and weight control, and etc.
TCI378 (Lactobacillus plantarum TCI378) is a probiotic extracted from Korean kimchi, and TCI507 (Lactobacillus plantarum TCI507) is a probiotic extracted from the oranges peels. These two strains of probiotics have been verified by in vitro experiments to have the effect of hydrolyzing bile salts, inhibition of the production of fat cells. Therefore, we want to evaluate whether the probiotics TCI308 and TCI507 have effects on reduction of body weight.

Start Date15 Jun 2021

Sponsor / Collaborator

National Taiwan University Hospital

100 Clinical Results associated with Lactobacillus plantarum TCI507

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100 Translational Medicine associated with Lactobacillus plantarum TCI507

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100 Patents (Medical) associated with Lactobacillus plantarum TCI507

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4

Literatures (Medical) associated with Lactobacillus plantarum TCI507

01 Aug 2018·Bulletin of Entomological ResearchQ3 · AGRICULTURAL & FORESTRY SCIENCE

Microbial composition affects the performance of an artificial Tephritid larval diet

Q3 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Pinto, R ; Rempoulakis, P ; Birke, A ; Nestel, D ; Nemny-Lavy, E ; Sela Saldinger, S

AbstractThe present study investigated the patterns of microorganisms in an artificial larval diet duringDacus ciliatus(Diptera;Tephritidae) larval development. Microbial population contents in the diet of total heterotrophic bacteria, yeast and molds, coliform and lactobacilli, and their dynamics during development, were monitored. Initially, the microbial composition in diet trays failing to produce viable pupae and in trays successfully producing pupae and adult flies was characterized. The failing diet trays contained large populations of lactobacilli that increased during larval development, and low populations of coliforms. In contrast, the successful diet showed an increasing population of coliforms and a low, or undetected, population of lactobacilli. To study the hypothesis that lactobacilli affectD. ciliatuslarval development, we conducted controlled inoculation experiments in whichLactobacillus plantarumwas added into fresh diet at the time of egg seeding.L. plantaruminoculated trays showed no production ofD. ciliatus. Control trays without lactobacilli inoculation showed variable results. One tray successfully produced viable pupae and adults, and showed a slight and slow increase in the indigenous populations of lactobacilli. The second tray, however, failed to produce pupae and showed a fast increase of the indigenous lactobacilli to very high levels. Monitored pH trends inL. plantarum-inoculated diet showed a sharp pH decrease during the first 4 days of larval development from 5 to less than 4 units, while successful diet, producing viableD. ciliatuspupae and adults, showed a moderate pH drop during most of the larval development period. The paper discusses the possible ecological interactions betweenD. ciliatuslarvae, the microbial content of the diet and the physical properties of the diet. The discussion also points out at the usefulness of this approach in understanding and managing mass production parameters of tephritid fruit flies industrial diets used for Sterile Insect Technique.

31 Oct 2013·Genome Announcements

Draft Genome Sequence of Lactobacillus plantarum Strain AY01, Isolated from the Raw Material of Fermented Goat Milk Cheese

Article

Author: Zheng, Hua-Jun ; Gong, Fu-Ming ; Li, Xiao-Ran ; Zhang, Zhong-Hua ; Luo, Yi-Yong ; Liu, Chen-Jian

ABSTRACTLactobacillus plantarum is an important probiotic that is isolated mostly from fermented foods. Here, we report the first draft genome sequence of L. plantarum strain AY01, isolated from the raw material of fermented goat milk cheese. This bacterium, with optimum growth at 30°C, has a G+C content of 43.68%.

Food & FunctionQ2 · MEDICINE

Investigating the growth performance, meat quality, immune function and proteomic profiles of plasmal exosomes in Lactobacillus plantarum-treated broilers with immunological stress

Q2 · MEDICINE

Article

Author: Wang, Yang ; Liu, Huawei ; Zhao, Fan ; Zhang, Kai ; Zhao, Jinshan

Exosomes are extracellular membranous nanovesicles that carry functional molecules to mediate cell-to-cell communication.

100 Deals associated with Lactobacillus plantarum TCI507

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