HTL-0014242

Tokyo, Japan and Cambridge, UK, 2 May 2025 – Nxera Pharma (“the Company” or “Nxera”; TSE: 4565) provides an update on operational activities and reports its consolidated results for the first quarter ended 31 March 2025. The full report can be found here. Chris Cargill, President and CEO of Nxera, commented: “As we mark one year since our transformation from Sosei Heptares to Nxera Pharma, I am incredibly proud of the progress we’ve made and how we have evolved. Our new identity has unified the Group and helped clarify our mission while clearly signalling our intent to lead the next era of biopharmaceutical innovation in Japan and globally. The strides we’ve made over the past year is a testament to the strength of our people, our partnerships, and the power of our NxWave™ platform to deliver promising new candidates for development across major disease areas with great unmet need. “We expect 2025 to be an important year across both for our partnered and in-house portfolios. With key data readouts anticipated from multiple clinical trials and several new studies due to commence, we are well positioned to deliver significant value for patients and shareholders alike.” Operational Highlights for Q1 2025 Development and commercialization agreements Assignment of Japan and Asia-Pacific (ex-China) rights for cenerimod, a promising S1P1 receptor modulator for autoimmune diseases, to Viatris Receipt of upfront payment of US$10 million, with additional milestone and royalty potential Agreement signed with Holling Bio-Pharma Corp. (“Holling”) to commercialize daridorexant, a dual orexin receptor antagonist, for sleep disorders in Taiwan Nxera will be responsible for the supply of drug product and Holling will be responsible for regulatory, commercial and distribution activities and will hold all regulatory approvalsFiling in Taiwan is expected in 2025, with a potential launch in 2026 Progress with partnered programs Neurocrine Biosciences, Inc. outlined clinical development plans for the partnered muscarinic agonist portfolio in 2025, including Initiation of Phase 3 registrational studies with NBI-1117568 (an oral, muscarinic M4-selective agonist) in schizophrenia in 1H 2025Initiation of a Phase 2 study with NBI-1117568 in bipolar mania in 2H 2025Initiation of a Phase 2 study with NBI-1117570 (a dual M1 / M4 agonist) in schizophrenia in 2H 2025Data readouts for NBI-1117570, NBI-1117567 (M1-preferring), and NBI-1117569 (M4-preferring) expected in 2025, all of which are being advanced in Phase 1 trials targeting neurological and neuropsychiatric conditions Tempero Bio initiated a Phase 2 trial of TMP-301 for alcohol use disorder TMP-301, a potent, selective and orally available mGluR5 negative allosteric modulator (NAM), was discovered using Nxera’s NxWave™ platform and is also in development for cocaine use disorder Corporate highlights Changes to Board of Directors Ms. Naoko Shimura and Ms. Nicola Rabson appointed as new External DirectorsMr. Shinichi Tamura, Chairman and founder of the Company, Mr. Tomohiro Tohyama and Mr. Kuniaki Kaga, former External Directors, also retired from the Board of Directors Post-period events Neurocrine initiated a Phase 3 registrational program of NBI-1117568 as a potential treatment for schizophrenia in May 2025 supported by positive top-line data from the Phase 2 study, which met its primary endpoint for the once-daily 20 mg dose (as reported in August 2024). The Phase 3 study is a global double-blind, placebo-controlled trial evaluating NBI-’568 in adults with a primary diagnosis of schizophrenia who are experiencing an acute exacerbation or relapse of symptoms. The study is expected to enroll approximately 280 patients. The primary endpoint of the study is a reduction from baseline in the Positive and Negative Syndrome Scale (PANSS). The key secondary endpoint is improvement in the Clinical Global Impression of Severity (CGI-S) scale. Executive appointments Mr. Kiyoshi Kaneko appointed as Chief Commercial Officer and Ms. Mariko Nakafuji promoted to Chief Legal Officer Financial Highlights for the Three-month Period ended 31 March 2025 Revenue totalled JPY 6,644 million (US$43.5 million*), an increase of JPY 2,033 million (US$12.5 million) vs. the prior year. This increase was primarily due to the inclusion of sales of QUVIVIQ® following its launch in the fourth quarter of 2024, as well as the occurrence of one R&D milestone event in the current quarter vs. no R&D milestone events in the prior corresponding period. R&D expenses totalled JPY 3,808 million (US$25.0 million), an increase of JPY 645 million (US$3.7 million) vs. the prior year. This increase primarily reflects an increased investment in R&D and the impact of the weaker Yen.SG&A expenses totalled JPY 3,701 million (US$24.3 million), an increase of JPY 51 million (a decrease of US$0.3 million) vs. the prior corresponding period. This increase was primarily due to incremental spend on personnel to strengthen organizational capabilities, offset by lower sales-related costs as a result of targeted cost savings.Operating loss totalled JPY 2,193 million (US$14.4 million) vs. an operating loss of JPY 3,076 million (US$20.7 million) in the prior year. This improvement in profitability reflects the combined effect of all movements explained above.Loss before income tax totalled JPY 2,156 million (US$14.1 million) vs. a loss before income tax of JPY 2,796 million (US$18.8 million) in the prior year. This improvement in profitability reflects the combined effect of all movements explained above.Net loss totalled JPY 760 million (US$5.0 million) vs. a net loss of JPY 3,281 million (US$22.1 million) in the prior year. This improvement in profitability reflects the combined effect of all movements explained above.Core operating loss** totalled JPY 625 million (US$4.1 million) vs. a core operating loss of JPY 931 million (US$6.3 million) in the prior corresponding period. Cash and cash equivalents as at 31 March 2025 amounted to JPY 34,465 million (US$230.0 million) having increased by JPY 2,197 million (US$24.3 million) from the beginning of the year. *Convenience conversion to US$ at the following rates: FY 2025: 1US$ =152.57 JPY; FY 2024: 1US$ =148.40 JPY; 31 Mar 2025: 1US$ = 149.85 JPY; 31 Dec 2024: 1US$ = 156.83 JPY ** Core operating profit / loss is an alternative performance measure which adjusts for material non-cash costs and one-off costs in order to provide insights into the recurring cash generation capability of the core business. –END– About Nxera PharmaNxera Pharma is a technology powered biopharma company, in pursuit of new specialty medicines to improve the lives of patients with unmet needs in Japan and globally. We have built an agile, new-generation commercial business in Japan to develop and commercialize innovative medicines, including several launched products, to address this high value, large and growing market and those in the broader APAC region. Behind that, and powered by our unique NxWave™ discovery platform, we are advancing an extensive pipeline of over 30 active programs from discovery through to late clinical stage internally and in partnership with leading pharma and biotech companies. This pipeline of potentially first- and best-in-class candidates is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across neurology/neuropsychiatry, metabolic diseases and immunology and inflammation. Nxera employs approximately 400 talented people at key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland) and Seoul (South Korea) and is listed on the Tokyo Stock Exchange (ticker: 4565). For more information, please visit www.nxera.life LinkedIn: @NxeraPharma | X: @NxeraPharma | YouTube: @NxeraPharma Enquiries: Nxera – Media and Investor RelationsShinya Tsuzuki, VP, Head of Investor RelationsShinichiro Nishishita, VP Investor Relations, Head of Regulatory DisclosuresMaya Bennison, Communications Manager+81 (0)3 5210 3399 | +44 (0)1223 949390 |IR@Nxera.life MEDiSTRAVA (for International Media)Mark Swallow, Frazer Hall, Erica Hollingsworth+44 (0)203 928 6900 | Nxera@medistrava.com Forward-looking statementsThis press release contains forward-looking statements, including statements about the discovery, development, and commercialization of products. Various risks may cause Nxera Pharma Group’s actual results to differ materially from those expressed or implied by the forward looking statements, including: adverse results in clinical development programs; failure to obtain patent protection for inventions; commercial limitations imposed by patents owned or controlled by third parties; dependence upon strategic alliance partners to develop and commercialize products and services; difficulties or delays in obtaining regulatory approvals to market products and services resulting from development efforts; the requirement for substantial funding to conduct research and development and to expand commercialization activities; and product initiatives by competitors. As a result of these factors, prospective investors are cautioned not to rely on any forward-looking statements. We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. Attachment FY25Q1_Tanshin_Nxera Pharma

Isomorphic Labs, a young company whose artificial intelligence technology for drug research has already landed partnerships with big pharmaceutical companies, unveiled $600 million in new financing this week as it looks to advance its own drug pipeline. London-based Isomorphic is an autonomous subsidiary of Alphabet. It came from DeepMind, a different Alphabet subsidiary that uses machine learning to solve problems. Isomorphic was formed in 2021 to build on the success of DeepMind’s AlphaFold, a technology that successfully predicted how a protein would fold based on its amino acid sequence. The company is led by founder and CEO Demis Hassabis, who also co-founded and leads DeepMind. Early last year, Isomorphic revealed two partners: Eli Lilly and Novartis. Both alliances, which span the discovery of small molecules for multiple undisclosed targets, came with upfront cash and the potential for milestone payments. Sponsored Post Tackling Rising Drug Costs and Growing Popularity of GLP-1’s See how Quantum Health is providing the steps to help their members tackle the cost of specialty medications and other drugs. By Quantum Health and MedCity News Isomorphic says its AI drug design engine has foundational AI models capable of working across multiple therapeutic areas and drug modalities. The company is not yet disclosing the targets or therapeutic areas of its internal research. But as an example of its capabilities, Isomorphic points to AlphaFold 3, which was released by the company and DeepMind last year. This technology can predict the structure and interactions of all of life’s molecules. Isomorphic said the new financing, its first external round, was led by Thrive Capital and included participation from GV and follow-on capital from earlier investor Alphabet. In addition to supporting its AI drug design engine, the capital will also help Isomorphic advance internal programs to the clinic. Isomorphic’s large financing comes amid investment headwinds. Capital raised by biotech companies in the first quarter of this year comes out to about $13 billion, analysts at William Blair said in a research note. That’s well below the $25.7 billion raised in the first quarter of 2024 and it’s also below the $18.8 billion quarterly average last year. Though 2024 started strong, the firm notes that biotech funding has declined sequentially for four consecutive quarters. Here’s a recap of other recent financings as the first quarter came to a close: presented by Health Tech The 5 Best Software to Buy for Managing a Spa Franchise Choosing the right software translates directly into better client management, operational efficiency and growth for your spa franchise. Discover which tool is best for your business. By Meevo —AIRNA raised $155 million to advance to Phase 1/2 testing with AIR-001, a potential treatment for alpha-1 antitrypsin deficiency. Venrock Healthcare Capital Partners led the Series B round, which was co-led by Forbion Growth. Here’s more about AIRNA’s RNA-editing therapy for AATD, which puts it in competition with Korro Bio and Wave Life Sciences, both in early clinical development with RNA-editing therapies for the rare liver protein deficiency. —Character Biosciences pulled in $93 million to reach the clinic with two internally discovered complement inhibitors, each in development for different stages of the dry form of age-related macular degeneration. The Series B financing was co-led by aMoon and Luma Group, both new investors in the startup. Character, a spinout of Clover Health, closed an $18 million Series A financing in 2022. —Epicrispr Biotechnologies raised $68 million as it prepares for Phase 1 testing of EPI-321, an epigenetic therapy that addresses the underlying cause of facioscapulohumeral muscular dystrophy (FSHD). The South San Francisco-based biotech’s therapies come from Gene Expression Modulation System, a technology that enables precise and durable control of gene expression. Epicrispr presented preclinical data for the FSHD therapy last fall during the European Society of Cell and Gene Therapy annual meeting. —Tempero Bio closed $70 million in funding to support TMP-301 for substance use disorders. The Oakland based company plans to advance the drug candidate two Phase 2 tests, one in alcohol use disorder and the other in cocaine use. 8VC led Tempero’s Series B financing. —Hillstar Bio launched with $67 million to support the development of immunotherapies for autoimmune diseases. The Boston-based startup says its therapies selectively deplete pathogenic cells while preserving healthy ones. The company’s lead program targets TRBV9-positive T cells; a clinical trial is planned for 2026 with an initial focus on axial spondyloarthritis and potentially other immune and inflammatory disorders. —Flagship Pioneering revealed its latest AI startup, Lila Sciences. While Lila’s technology allows it to process large amounts of data and make predictions, and the company says its technology also helps scientists design and conduct new experiments, generating hypotheses and testing them in real-world environments. Lila isn’t developing its own drugs. Rather, it’s looking to strike up partnerships with other companies aiming to leverage the technology for applications ranging from drug R&D, carbon capture, and sustainable agriculture. While Flagship startups typically launch with $50 million from the startup creator, Lila is backed by $200 million in committed seed financing from a syndicate that includes General Catalyst, March Capital, and a subsidiary of the Abu Dhabi Investment Authority, among others. —Augustine Therapeutics closed €78 million (about $85 million) for drugs that block the enzyme HDAC6 to treat neuromuscular, neurodegenerative, and cardio-metabolic diseases. The Leuven, Belgium-based company will apply the new capital to Phase 1/2 testing of lead program AGT-100216, an experimental treatment for rare neuromuscular disorder Charcot-Marie Tooth disease. Novo Holdings and Jeito Capital co-led Augustine’s Series A financing. —Osivax raised €10 million to continue development of OVX836, a broad-spectrum influenza vaccine candidate that has reached Phase 2b testing. The financing, which Lyon, France-based Osivax described as the first close of a Series B financing, added new investor Meiji Seika Pharma Co. —Montara Therapeutics’ expanded its seed round by $20 million as the company advances its lead epilepsy program to the preclinical research that could support an investigational new drug application (IND). San Francisco-based Montara develops “BrainOnly” drugs, therapies that selectively target the central nervous system while blocking harmful peripheral effects. With the expanded financing, the round now totals $28 million. —Ampersand Biomedicines revealed $65 million in financing to bring programs in immuno-oncology and immuno-inflammation into IND-enabling studies. The Flagship Pioneering-founded startup develops biologic drugs from a platform technology that identifies “addresses,” markers found on disease-driving targets but not on healthy cells. Eli Lilly joined Flagship in Ampersand’s Series B round, which comes two years after the drug discovery biotech’s launch. —Arbor Biotechnologies raised $73.9 million to finance Phase 1/2 testing of its gene therapy for primary hyperoxaluria type 1, a rare enzyme deficiency. In vivo editing by the Arbor gene therapy, ABO-101, is intended to knock down expression of the HAO1 gene that drives the disease. Arch Venture Partners and TCGX led the Series C round for Cambridge-based Arbor, whose last financing was a $215 million Series B round in 2021. —RegCell announced its relocation from Japan to Emeryville, California, as it progresses toward the clinic with an experimental regulatory T cell (Treg) treatment for autoimmune disease. The technology of RegCell generates epigenetically reprogrammed, antigen specific Tregs intended to restore immune tolerance. The company is financially backed by $8.5 million in seed financing and up to $37.3 million in non-dilutive funding from The Japan Agency for Medical Research and Development. —Cambridge, U.K.-based Maxion Therapeutics revealed £58 million (about $72 million) in financing to reach human testing with MAX001, a potential treatment for a spectrum of inflammatory diseases such as atopic dermatitis and inflammatory bowel disease. The company’s drugs combine knottins, a type of protein, with antibodies. These “KnotBodies” are intended to modulate ion channels and G protein-coupled receptors. General Catalyst led Maxion’s Series A financing. —Latigo Biotherapeutics closed $150 million in financing for its non-opioid pain drug pipeline. Latigo is in Phase 2 testing with lead program LTG-001, a blocker of a sodium channel called NaV1.8. That’s the same target as Vertex Pharmaceuticals’ recently approved non-opioid pain drug, Journavx. Blue Owl Capital led Latigo’s Series B round. —Curevo Vaccine closed $110 million to continue clinical development of amezosvatein, an experimental shingles vaccine. In addition to extending the Phase 2 program to an additional 640 participants, the company aims to finalize dose selection for the planned Phase 3 study. Seattle-based Curevo also said Moncef Slaoui, the former GSK vaccine executive and chief scientific advisor to Operation Warp Speed, has been named chair of the company’s board of directors. Medixci led Curevo’s Series B financing. —Insilico Medicine, a company that employs generative AI to drug discovery and development, raised $110 million for its pipeline and technology. Its most advanced drug candidate is rentosertib (formerly ISM001-055), a small molecule in mid-stage clinical development for idiopathic pulmonary fibrosis. A private equity fund of Value Partners Group led Insilico’s Series E financing. —Vivace Therapeutics raised $35 million to advance a potentially first-in-class drug that addresses the Hippo pathway. Lead Vivace drug VT3989 blocks TEAD proteins in this pathway, which contribute to cancer when dysregulated. VT3989 is being readied for Phase 3 testing in mesothelioma. RA Capital Management led the San Mateo, California-based biotech’s Series D financing. —Callio Therapeutics emerged with $187 million for its new twist on antibody drug conjugates (ADC) for cancer. Currently available ADCs carry a single drug payload. Callio, which splits its operations between Seattle and Singapore, is developing multi-payload ADCs. Frazier Life Sciences led Callio’s Series A financing, which it will use to achieve clinical proof of concept for a dual payload ADC targeting the cancer protein HER2. The target of a second Callio program is undisclosed. —Garuda Therapeutics raised $50 million to support its R&D of off-the-shelf hematopoietic stem cell therapies for potential applications in a range of blood disorders. Investors in the Series A-1 round include OribiMed, Northpond Ventures, Cormorant Asset Management, and Japanese pharma company Kyowa Kirin. —Cancer biotech Eikon Therapeutics closed $350 million in financing to support a pipeline that includes lead program EIK1001, which is in Phase 3 testing in advanced melanoma. This drug is a small molecule that activates TLR7/8 receptors to spark an immune response against cancer. —Bambusa Therapeutics, startup developing bispecific antibodies applications in immunology and inflammation, said its Series A financing raised about $90 million. Lead program BBT001 is being readied for Phase 1 testing in dermatological conditions. New investor RA Capital Management led the Boston-based biotech’s financing. —Abcuro raised $200 million to support ulviprubart, a drug in Phase 2/3 testing for inclusion body myositis, an autoimmune disease in which T cells chronically attack muscle tissue. The drug is an antibody that blocks a target called KLRG1. New Enterprise Associates led the Newton, Massachusetts-based biotech’s Series C financing. —Newleos Therapeutics unveiled clinical-stage neuropsychiatric drug candidates licensed from Roche and backed by $93.5 million in funding. Lead Newleos program NTX-1955 target the GABA A receptor subunit gamma 1 as a potential treatment for anxiety. Newleos plans to advance this small molecule to proof-of-concept clinical testing in generalized anxiety disorder. Goldman Sachs Alternatives led Newleos’s Series A financing.