Investigation into the effects of acute heat stress on stress level, meat quality, myofibrillar proteins properties and serum metabolites release of Muscovy ducks (Cairina moschata)

Article

Author: Huang, Ming ; Li, Zimu ; Huang, Jichao ; Zhu, Zongshuai ; Huang, Tianran ; Xiao, Mengchao

This study systematically investigated the effects of acute heat stress (AHS) on Muscovy ducks, focusing on plasma stress indicators, meat quality, myofibrillar proteins (MPs) properties, and serum metabolite profiles. AHS significantly elevated stress level, impairing meat quality, as evidenced by higher L* value, shear force, drip loss, and cooking loss (P < 0.05). It also induced MPs oxidation and aggregation, reflected by elevated carbonyl content, turbidity, zeta potential, and particle size. MPs structural alterations were confirmed by fluorescence quenching and increased exposure of hydrophobic groups. Correlation analysis revealed strong associations between physicochemical changes and MPs oxidation. Metabolomic analysis identified 161 and 105 differential metabolites in the CON vs. LS and CON vs. SS comparisons, respectively, involving 25 metabolic pathways related to energy, amino acids, and fatty acids. These findings provide novel insights into the molecular pathways of AHS-induced meat quality deterioration and reveal potential intervention timing for the poultry industry.

01 Jul 2025·Journal of Affective Disorders

Association between dietary intake of flavonoids and perimenopausal depression, and the mediating role of high-density lipoprotein cholesterol: Evidence from NHANES 2005-2018

Article

Author: Li, Siqi ; Li, Jian ; Wang, Jing ; Lv, He ; Hou, Yali ; Zhao, Xiujuan ; Dai, Jiaohua

BACKGROUNDPerimenopausal depression seriously harms women's physical and mental health, and there is currently no safe and effective prevention and treatment method. Flavonoids not only have antidepressant effects, but can also promote the synthesis and utilization of high-density lipoprotein cholesterol (HDL-c), which are closely associated with depression. This study aimed to explore the association between flavonoid intake and the risk of perimenopausal depression and the mediating role of HDL-c.METHODSThe data of this study were collected from the US National Health and Nutrition Examination Survey (NHANES) continuously from 2005 to 2018, and flavonoid intakes data were extracted from the Food and Nutrient Database for Dietary Studies. Multivariate logistic regression was used to estimate the association between flavonoid intake and the risk of perimenopausal depression, and the mediating effect model was constructed to explore the impact of HDL-c on the correlation.RESULTSTotal 4603 perimenopausal female participants were included in this study, results showed that flavonoid intake was inversely associated with the risk of perimenopausal depression, and positively associated with serum HDL-c levels. These associations persisted after adjustment for relevant covariates. Serum HDL-c mediated the association between flavonoid intake and the risk of perimenopausal depression.LIMITATIONSAs a cross-sectional study, which cannot determine the causal relationship between flavonoid intake and perimenopausal depression.CONCLUSIONOur research showed that flavonoid intake, perimenopausal depression, and serum HDL-c are pairwise correlated, revealing that higher flavonoid intake was associated with a lower risk of perimenopausal depression, which may be mediated in part by serum HDL-c.

01 Jun 2025·Food Microbiology

Enhancing the quality of dark tea through fermentation with Aspergillus niger: Unveiling aroma and taste characteristics

Article

Author: Zhong, Kai ; Huang, Yina ; Gan, Renyou ; Du, Sicheng ; Xiao, Yue ; Wu, Yanping ; Li, Maoyun ; Gao, Hong

Amidst the increasing demand for premium dark tea, the utilization of Aspergillus niger-inoculated fermentation has emerged as a potential solution to address the challenges associated with extended processing cycles and inconsistent quality. This study comprehensively investigated the efficacy and mechanisms of A. niger PW-2 inoculation in enhancing dark tea quality compared to spontaneous fermentation, using metabolomics, electronic tongue, molecular docking, and high-throughput sequencing. A. niger PW-2 shaped the fungal community within 7 days, degrading terpene glycosides and lactones while generating terpenoids and unsaturated fatty acids, which enriched the floral aroma of PW-2-inoculated fermentation dark tea (AF). Flavonoid degradation and reduced theaflavins/thearubigins levels in AF decreased astringency, while increased bitter dipeptides and isoflavonoids enhanced bitterness, and the accumulation of umami dipeptides and theabrownins improved umami taste perception of AF. Molecular docking identified key compounds responsible for astringency (kaempferol glycosides), bitterness (6″-caffeoylisoorientin, kaempferol 4'-glucoside 7-rhamnoside, dihydrodaidzein 7-O-glucuronide), and umami (3-O-p-trans-coumaroylalphitolic acid, dihydrodaidzein 7-O-glucuronide, 1-methoxyphaseollidin). Overall, A. niger PW-2 inoculation accelerates fermentation process and enhances flavor characteristics of dark tea, offering a promising approach for high-quality dark tea production.

100 Deals associated with FTO inhibitors(Anhui Medical University)

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Indication	Highest Phase	Country/Location	Organization	Date
Obesity	Preclinical	China	Anhui Medical University	28 Mar 2025

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