Dolutegravir/Lamivudine/Tenofovir Disoproxil Fumarate

Primary objective: To investigate the pharmacokinetic characteristics of the test formulation and reference formulation in healthy trial participants after oral administration, and to evaluate their bioequivalence. Secondary objective: To evaluate the safety of the test formulation and reference formulation in healthy trial participants.

Main purpose: To investigate the in vivo pharmacokinetic characteristics of the test preparation (Dolutegravir Lamivudine Tenofovir Tablets (Specifications: 50mg/300mg/300mg)) produced by Shanghai Desano Pharmaceutical Group Co., Ltd. and the reference preparation (Dolutegravir Sodium Tablets (Tivicay®, Specification: 50mg) + Lamivudine Tablets (EPIVIR®, Specification: 300mg) + Tenofovir Disoproxil Fumarate Tablets (Viread®, Specification: 300mg)) in Chinese healthy subjects after single oral administration under fasting/postprandial conditions, and to evaluate the bioequivalence of the test preparation and the reference preparation. Secondary objective: To evaluate the safety of a single oral dose of the test formulation (dolutegravir lamivudine and tenofovir disoproxil fumarate tablets (specifications: 50 mg/300 mg/300 mg)) produced by Shanghai Desano Pharmaceutical Group Co., Ltd. and the combined administration of the reference formulation (dolutegravir sodium tablets (Tivica®, specification: 50 mg) + lamivudine tablets (EPIVIR®, specification: 300 mg) + tenofovir disoproxil fumarate tablets (Viread®, specification: 300 mg)) in healthy Chinese subjects.