3-HPT

In this study, the fruits of both mature and air-dried figs were exposed to selective sequential extracting processes using soxhlet.Different polarity and non-polarity solvents were used to increase the yield of the isolated extractsThe aim of current work is to deal with the synthesis of a novel compound 2-benzhydrylsulfinyl-n-hydroxyacetamide-Na from fig fruit and study its effect as anticancer and anti-proliferative agent against SKOV-3, and AMJ-13 cells.Treated cancer cells with 2-benzhydrylsulfinyl-n-hydroxyacetamide-Na significantly increased ROS synthesis, with subsequent reduction of the MMP through mechanisms that included Bax upregulation P⁵³, Caspase-8, and Caspase-9 and Bcl-2 downregulation.The outcomes of the current study show that 2-benzhydrylsulfinyl-n-hydroxyacetamide-Na extracted from fig fruit suppressed cancers cells' proliferation, resulting in apoptosis as a novel pathway that involves mitochondrial mechanism via activated P53 and caspase-8 signaling.In addition, the extract exerted no toxic effects, neither on serum levels of liver functional enzymes nor on the normal histol. architecture of the lungs and spleen.We demonstrated how the 2-benzhydrylsulfinyl-n-hydroxyacetamide-Na affects cancer cells along with a study the possible mechanisms involved in this effect which is mitochondrial damage and P⁵³ pathway.We conclude that 2-benzhydrylsulfinyl-n-hydroxyacetamide-Na holds a promising potential as an anticancer therapeutic agent.

Castor plant (Ricinus communis) is a fast growing, perennial shrub also known as wonder tree from Euphorbiaceae family.India ranks globally first with production of 87% of the castor seed, while second and third largest producer countries, China and Brazil produced 5% and 1%, resp.Hydrothermal liquefaction (HTL) is one of the most promising thermochem. conversion process used to convert wet/high moisture biomass to biofuels and value-added hydrocarbons.HTL of castor residue (stem and leaves) was performed at 260, 280, 300 °C and 15, 30, 60, 90 min.Investigations on the effect of temperature and residence time on distribution of products (bio-oil, bio-char) indicated the maximum Total Bio-oil (TBO) yield of c.a. 15.8 wt% was obtained at 300 °C at 60 min.The major compounds observed by GC-MS were phenols and their derivatives, aromatic hydrocarbons, N-containing compounds, acids.In addition, the recovery of carbon and corresponding energy recovery with respect to castor residue indicated that the carbon and energy recovery for bio-oil 1 were 24.23% and 31.08% resp.An increase in the carbon and decrease of oxygen content in bio-oil (BO) demonstrates that the castor residue can be used as a potential feedstock for bioenergy applications.