Tegaserod maleate

SOUTH SAN FRANCISCO, Calif., March 08, 2023 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today announced the appointments of Darren Cline and Thomas McCourt to its Board of Directors. "I am pleased to welcome Darren and Thomas whose extensive commercial and operational expertise will be crucial as we progress toward late-stage clinical development,” said Bernard Coulie, M.D., Ph.D., President and Chief Executive Officer of Pliant Therapeutics. “I am confident that their insights and experience will prove invaluable as we execute on our strategy to bring potentially transformative therapeutics to patients.” Mr. Cline is a seasoned pharmaceutical industry executive with over 30 years of strategic and operational experience in building commercial organizations. Mr. Cline currently serves as Chief Executive Officer and President of Epygenix Therapeutics, a clinical stage company developing therapies for rare epilepsies. Prior to this, Mr. Cline served as the U.S. Chief Commercial Officer of GW Pharmaceuticals (acquired by Jazz Pharmaceuticals), where he was responsible for commercial and medical affairs activities associated with Epidiolex®. Prior to joining GW Pharmaceuticals, Mr. Cline held the role of Executive Vice President, Commercial at Seagen where he managed operations with the commercial launch of Adcetris®. Prior to joining Seagen, Mr. Cline held key commercial leadership roles at Intermune, Alexion and Amgen. Mr. Cline currently serves on the board of directors of Pyxis Oncology. Mr. Cline received his B.S. in Business Marketing from San Diego State University and an MBA from Pepperdine University. Mr. McCourt is an accomplished biopharmaceutical executive with over 30 years of experience building commercial strategies and capabilities across multiple companies. Mr. McCourt currently serves as Chief Executive Officer of Ironwood Pharmaceuticals, a role he has held since June 2021. Since joining Ironwood in 2009, Mr. McCourt has served as Senior Vice President of Marketing and Sales, Chief Commercial Officer, and President, leading the commercial launch of LINZESS®, now a blockbuster product. Prior to joining Ironwood, Mr. McCourt led the U.S. brand team for Prolia® at Amgen and held several senior commercial roles within Novartis AG, including leading the launch and growth of ZELNORM™. In addition, Mr. McCourt was a founding team member at Astra Merck Inc., where he led the development of the medical affairs and science liaison group, and then served as brand manager for PRILOSEC® and NEXIUM®. Mr. McCourt also served as an independent director and chair of the nominating and corporate governance committee at Acceleron Pharma before their acquisition. In 2022, he received the ASGE President’s Award in recognition of his pivotal contribution to the field of gastrointestinal endoscopy and treatment. Mr. McCourt received his B.S. degree in Pharmacy and Pharmacology from the University of Wisconsin at Madison. Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "will," "expect," "anticipate," "estimate," "intend," and similar expressions (as well as other words or expressions referencing future events, conditions, or circumstances) are intended to identify forward-looking statements. These statements include those regarding development of our product candidates and corporate strategy. Because such statements deal with future events and are based on our current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Pliant Therapeutics could differ materially from those described in or implied by the statements in this press release. These forward-looking statements are subject to risks and uncertainties, including those related to the development and commercialization of our product candidates, including any delays in our ongoing or planned preclinical or clinical trials, the impact of the ongoing COVID-19 pandemic on our business, operations, clinical supply and plans, our reliance on third parties for critical aspects of our development operations, the risks inherent in the drug development process, the risks regarding the accuracy of our estimates of expenses and timing of development, our capital requirements and the need for additional financing, and our ability to obtain and maintain intellectual property protection for our product candidates. These and additional risks are discussed in the sections titled "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in our Annual Report on Form 10-K filed for the year ended December 31, 2021 which we filed with the SEC on March 1, 2022, as updated by our Quarterly Report on Form 10-Q for the quarter ended September 30, 2022, which we filed with the SEC on November 8, 2022, each available on the SEC's website at Unless otherwise noted, Pliant is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise. About Pliant Therapeutics, Inc. Pliant Therapeutics is a clinical stage biopharmaceutical company focused on discovering and developing novel therapies for the treatment of fibrosis. Pliant's lead product candidate, bexotegrast (PLN-74809), is an oral small molecule dual selective inhibitor of αvß6 and αvß1 integrins that is in development in the lead indications for the treatment of idiopathic pulmonary fibrosis, or IPF, and primary sclerosing cholangitis, or PSC. Bexotegrast has received Fast Track Designation and Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) in IPF and PSC and Orphan Drug Designation from the European Medicines Agency in IPF and PSC. Pliant is currently conducting Phase 2a trials of bexotegrast in the lead indications of IPF and PSC. Pliant has also developed PLN-1474, a small molecule, selective inhibitor of αvß1 for the treatment of nonalcoholic steatohepatitis, or NASH with liver fibrosis. Pliant is initiating a Phase 1 study for its third clinical program, PLN-101095, a small molecule, dual-selective inhibitor of αvß8 and αvß1 integrins, that is being developed for the treatment of solid tumors. In addition to clinical stage programs, Pliant currently has a preclinical program targeting muscular dystrophies. For additional information about Pliant Therapeutics, visit and follow us on Twitter, LinkedIn, Facebook and YouTube. Investor and Media Contact: Christopher Keenan Vice President, Investor Relations and Corporate Communications Pliant Therapeutics, Inc. IR@Pliantrx.com

Dr. Cataldi Brings Over Two Decades of Clinical Research and Drug Development Experience in Gastroenterology and ImmunologyNEW YORK, Sept. 06, 2022 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ: LABP), a clinical-stage biopharmaceutical company developing novel, oral medicines for patients with autoimmune diseases, today announced the appointment of Fabio Cataldi, MD, as the Company’s Chief Medical Officer, effective September 5, 2022. “We are thrilled to welcome Fabio to Landos, and look forward to benefitting from his extensive clinical and drug development experience as we finalize our portfolio review and execute a focused plan to pursue what we believe are the Company’s most promising molecules and target indications,” said Greg Oakes, President and Chief Executive Officer of Landos. “Fabio’s clinical and research expertise in gastroenterology and immunology, particularly in ulcerative colitis (UC), will be integral as we look to advance NX-13 following our recent announcement of positive top-line results from our Phase 1b trial in UC patients.” Dr. Cataldi joins Landos with more than twenty years of successful experience in the development and commercialization of innovative therapies. He brings deep clinical, medical and scientific knowledge and expertise in immunology and gastroenterology, having served in senior research and development roles at Arena Pharmaceuticals, AbbVie, Shire, Pfizer, Biogen and Novartis. Most recently, Dr. Cataldi served as Arena’s Vice President and Therapeutic Area Head Gastroenterology, where he helped lead the development of etrasimod, until its sale to Pfizer for nearly $7 billion. “Fabio’s appointment as Chief Medical Officer is an important step as we look to continue selectively growing our leadership team with the talent and expertise that we need to successfully advance our pipeline. We are in the final stages of reviewing our clinical development plans, and are planning to provide a comprehensive update later this year,” continued Mr. Oakes. “I am excited to join Landos at such a pivotal time for the Company,” said Dr. Cataldi. “Having spent the majority of my career focused on immunology and gastroenterology drug development, I am looking forward to leveraging my background and experience as I work with Greg and the leadership team to build on Landos’ strong clinical foundation and deliver on its mission of addressing the therapeutic gap for patients with autoimmune diseases.” About Fabio Cataldi, MDDr. Cataldi has over twenty years of diverse and extensive experience in medicine and drug development in the United States and Italy. He most recently served as Vice President and Therapeutic Area Head of Gastroenterology at Arena Pharmaceuticals, where he led the development of etrasimod in inflammatory bowel disease (IBD) and other gastrointestinal (GI) indications and expanded the immunology portfolio. Prior to joining Arena Pharmaceuticals, Dr. Cataldi served as Team Lead of Gastroenterology and Immunology in Global Pharmaceutical Research and Development at AbbVie. Previously, Dr. Cataldi worked at Shire as Vice President of Clinical Development in Internal Medicine/Gastroenterology, where he led the expansion of the IBD portfolio with the out licensing of the anti-MAdCAM antibody from Pfizer. Before Shire, Dr. Cataldi served as Pfizer’s Senior Director of Gastroenterology Biotherapeutics Clinical Programs in Worldwide R&D, where he led the expansion of the Immunology and GI portfolio with assets targeting multiple diseases beyond IBD, including rheumatoid arthritis, systemic lupus erythematosus and dermatology conditions. Earlier in his career, Dr. Cataldi held roles at: Biogen Idec, where he oversaw the approval and launch of Tysabri in Crohn’s Disease; Novartis, where he supported the launch of Zelnorm for treatment of irritable bowel syndrome with constipation; Solvay Pharmaceuticals, where he helped with the New Drug Admission process with the U.S. Food and Drug Administration for Creon; and Beth Israel Deaconess Medical Center in Boston, MA. Dr. Cataldi holds an MD from the Second University of Naples (SUN) in Medicine and Surgery. About Landos BiopharmaLandos Biopharma is a clinical-stage biopharmaceutical company focused on the discovery and development of oral therapeutics for patients with autoimmune diseases. We believe we were the first to identify and target LANCL2, NLRX1 and PLXDC2, which are immunometabolic pathways or targets. We have identified seven novel immunometabolic pathways or targets based on predictions of immunometabolic function using a proprietary advanced artificial intelligence-based integrated computational and experimental precision medicine platform. Our near-term focus is on our clinical-stage programs including omilancor for the treatment of UC, NX-13 for the treatment of UC, and LABP-104 for the potential treatment of systemic lupus erythematosus and rheumatoid arthritis. For more information, please visit www.landosbiopharma.com. Cautionary Note on Forward-Looking Statements Statements in this press release about future expectations, plans and prospects for Landos Biopharma, Inc. (the “Company”), including statements about the Company’s strategy, clinical development and regulatory plans for its product candidates, including NX-13, and other statements containing the words “anticipate”, “plan”, “expect”, “may”, “will”, “could”, “believe”, “look forward”, “potential”, the negatives thereof, variations thereon and similar expressions, or any discussions of strategy constitute forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the uncertainties inherent in the initiation and enrollment of future clinical trials, expectations of expanding ongoing clinical trials, availability and timing of data from ongoing clinical trials, expectations for regulatory approvals, other matters that could affect the availability or commercial potential of the Company’s product candidates and other similar risks. Risks regarding the Company’s business are described in detail in the Company’s filings with the Securities and Exchange Commission (“SEC”), including in its Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q, which are available on the SEC’s website at www.sec.gov. Additional information will be made available in other filings that the Company makes from time to time with the SEC. Such risks may be amplified by the impacts of the COVID-19 pandemic. In addition, the forward-looking statements included in this press release represent the Company’s views only as of the date hereof. The Company anticipates that subsequent events and developments will cause the Company’s views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so, except as may be required by law. These forward-looking statements should not be relied upon as representing the Company’s views as of any date subsequent to the date hereof. Contacts Tanner Kaufman / Kara SperryJoele Frank, Wilkinson Brimmer Katcher212-355-4449