Delving into the Latest Updates on TT-00973 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

Mechanism

AXL modulators(AXL receptor tyrosine kinase modulators), FLT3 modulators(Tyrosine-protein kinase receptor FLT3 modulators)

Therapeutic Areas

NeoplasmsHemic and Lymphatic Diseases

Active Indication

Advanced Malignant Solid NeoplasmAcute Myeloid LeukemiaMyelodysplastic Syndromes

Inactive Indication-

Originator Organization

TransThera Sciences (Nanjing), Inc.Startup

Active Organization

TransThera Sciences (Nanjing), Inc.Startup

Inactive Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

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主要目的: 1、评估晚期实体瘤患者口服TT-00973-MS片的耐受性和安全性； 2、探索晚期实体瘤患者口服TT-00973-MS片的最大耐受剂量和/或临床II期推荐剂量次要目的： 1、描述晚期实体瘤患者单次和多次口服TT-00973-MS片的药代动力学特征； 2、初步评估TT-00973-MS片在晚期实体瘤患者中的抗肿瘤活性；探索性目的： 1、探索TT-003-MS片抗肿瘤活性与肿瘤生物标志物的关系。

[Translation]

Main objectives: 1. Evaluate the tolerability and safety of oral TT-00973-MS tablets in patients with advanced solid tumors; 2. Explore the maximum tolerated dose and/or clinical phase II recommended dose of oral TT-00973-MS tablets in patients with advanced solid tumors Secondary objectives: 1. Describe the pharmacokinetic characteristics of single and multiple oral TT-00973-MS tablets in patients with advanced solid tumors; 2. Preliminary evaluation of the anti-tumor activity of TT-00973-MS tablets in patients with advanced solid tumors; Exploratory objectives: 1. Explore the relationship between the anti-tumor activity of TT-003-MS tablets and tumor biomarkers.

Start Date11 Apr 2023

Sponsor / Collaborator

TransThera Sciences (Nanjing), Inc.Startup

NCT05673538 / Not yet recruitingPhase 1

A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TT-00973-MS Tablets in Patients With Advanced Solid Tumors

This study is a multicenter, open-label, phase 1 study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of TT-00973-MS tablets in patients with solid tumors.

Start Date01 Jan 2023

Sponsor / Collaborator

TransThera Sciences (Nanjing), Inc.Startup

100 Clinical Results associated with TT-00973

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100 Translational Medicine associated with TT-00973

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100 Patents (Medical) associated with TT-00973

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100 Deals associated with TT-00973

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Advanced Malignant Solid Neoplasm	Phase 1	CN	TransThera Sciences (Nanjing), Inc.Startup	01 Jan 2023
Acute Myeloid Leukemia	Phase 1	US	TransThera Sciences (Nanjing), Inc.Startup	07 Mar 2022
Myelodysplastic Syndromes	Phase 1	US	TransThera Sciences (Nanjing), Inc.Startup	07 Mar 2022