Author: Ma, Jianchao ; Hu, Penghua ; Fu, Xia ; Wen, Feng ; Huang, Renwei ; Li, Sijia ; Li, Zhuo ; Wu, Xiuchuan ; Fu, Lei ; Liang, Xinling ; Shi, Wei ; Wu, Suijing ; Feng, Zhonglin ; Liu, Shuangxin ; Tao, Yiming ; He, Chaosheng ; Li, Bohou ; Chen, Xueqin
Anemia is a common complication of chronic kidney disease (CKD). Recombinant human erythropoietin (rHu-EPO) is used extensively in patients with CKD. However, anti-erythropoietin (anti-EPO) antibody has been reported during rHu-EPO treatment, which causes pure red cell aplasia (PRCA). We presented a case of 75-year-old man, who underwent hemodialysis for 2 years. He developed PRCA during rHu-EPO treatment. The rHu-EPO was immediately discontinued, and the patient was given roxadustat treatment. After 6 months of roxadustat treatment, the anti-EPO antibody was disappeared, and hemoglobin recovered normal range. The results suggest that roxadustat can be used to treat patients with anti-EPO antibody-mediated PRCA without immunosuppressive therapy.