Delving into the Latest Updates on YPS345 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target-

Mechanism-

Therapeutic Areas

Infectious DiseasesRespiratory DiseasesOther Diseases

Active Indication

PneumoniaPulmonary FibrosisRadiation Pneumonitis

Inactive Indication-

Originator Organization

Chinese Academy of Sciences

Active Organization

Institute of Biophysics of Chinese Academy of Sciences

Topfond Pharmaceutical Co. Ltd.

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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This trial used a placebo as a control group and primary lung cancer patients who developed grade 1 or 2 radiation pneumonitis and did not require hormone therapy as subjects. It preliminarily evaluated the safety and efficacy of different doses of YPS345 tablets in reducing the incidence of grade 2 or above radiation pneumonitis requiring hormone therapy.

Start Date02 Dec 2021

Sponsor / Collaborator

Topfond Pharmaceutical Co. Ltd.

[+1]

CTR20191293 / CompletedPhase 1

评估YPS345片在健康志愿者中的安全、耐受性和药代动力学——一项单中心、双盲、随机、安慰剂对照的I期临床研究

[Translation] Evaluation of the safety, tolerability and pharmacokinetics of YPS345 tablets in healthy volunteers: a single-center, double-blind, randomized, placebo-controlled phase I clinical study

（1）评估在健康志愿者中YPS345片单次递增口服给药的安全性和耐受性，并与安慰剂比较。（2）评估在健康志愿者中YPS345片多次递增口服给药的安全性和耐受性，并与安慰剂比较。

[Translation]

(1) To evaluate the safety and tolerability of single ascending oral administration of YPS345 tablets in healthy volunteers and compare it with placebo. (2) To evaluate the safety and tolerability of multiple ascending oral administration of YPS345 tablets in healthy volunteers and compare it with placebo.

Start Date22 Jul 2019

Sponsor / Collaborator

Topfond Pharmaceutical Co. Ltd.

[+1]

100 Clinical Results associated with YPS345

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100 Translational Medicine associated with YPS345

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100 Patents (Medical) associated with YPS345

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100 Deals associated with YPS345

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Pneumonia	Phase 2	CN	Institute of Biophysics of Chinese Academy of Sciences	02 Dec 2021
Pneumonia	Phase 2	CN	Topfond Pharmaceutical Co. Ltd.	02 Dec 2021
Pulmonary Fibrosis	Phase 2	CN	Institute of Biophysics of Chinese Academy of Sciences	02 Dec 2021
Pulmonary Fibrosis	Phase 2	CN	Topfond Pharmaceutical Co. Ltd.	02 Dec 2021
Radiation Pneumonitis	Phase 2	CN	Institute of Biophysics of Chinese Academy of Sciences	02 Dec 2021
Radiation Pneumonitis	Phase 2	CN	Topfond Pharmaceutical Co. Ltd.	02 Dec 2021