Delving into the Latest Updates on Gilvusmycin with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Action-

Mechanism-

Therapeutic Areas

Neoplasms

Active Indication-

Inactive Indication

Neoplasms

Originator Organization

Kirin Brewery Co. Ltd.

Active Organization-

Inactive Organization

Kirin Brewery Co. Ltd.

License Organization-

Drug Highest PhaseDiscontinuedPreclinical

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC38H34N6O8

InChIKeyXUBJLJZOSKJNMY-UHFFFAOYSA-N

CAS Registry195052-09-6

This study successfully produced gilvusmycin by harnessing two highly homologous BGCs of gilvusmycin and CC-1065.Although no BGC has been identified for this natural product so far, our work strongly suggests that this BGC from Streptomyces indeed encodes gilvusmycin.We have successfully produced gilvusmycin by harnessing two highly homologous BGCs of gilvusmycin and CC-1065.Although no BGC has been identified for this natural product so far, our work strongly suggests that this BGC from Streptomyces sp.NRRL B-1347 (and S. yokosukanensis DSM 40224) indeed encodes gilvusmycin.Related BGCs are also natural DNA elements that can be used for synthetic biol.For example, compound 3 here is a newly discovered 'unnatural' natural product.Therefore, the strategy used in our present study is significant because such a strategy can also be harnessed to create new mols. using highly homologous BGCs.

01 Jan 1999·The Journal of AntibioticsQ4 · MEDICINE

Gilvusmycin, a New Antitumor Antibiotic Related to CC-1065.

Q4 · MEDICINE

Article

Author: Toshiyuki Isoe ; Yusuke Tokoro ; Kazutoshi Shindo

A new antitumor antibiotic gilvusmycin was isolated from the culture broth of Streptomyces sp. QM16. The structure of gilvusmycin was related to CC-1065 and determined by NMR spectral analysis. Gilvusmycin exhibited antitumor activity against murine leukemia P388 in vivo.

RSC Chemical Biology

Yatakemycin biosynthesis requires two deoxyribonucleases for toxin self-resistance

Article

Author: Walker, Allison S. ; Dorival, Jonathan ; Eichman, Brandt F. ; Yuan, Hua ; Tang, Gong-Li

The natural product yatakemycin (YTM) is a potent antimicrobial DNA damaging agent. YtkR4 and YtkR5 are deoxyribonucleases that provide resistance to YTM toxicity by removing the a basic site produced by YtkR2 cleavage of a YTM-adenosine lesion.

100 Deals associated with Gilvusmycin

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