Last update 28 Jan 2025

OPC-131461

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
OPC 131461, OPC131461
Target
AVPR1A x AVPR2
Mechanism
AVPR1A antagonists(Vasopressin V1a receptor antagonists), AVPR2 antagonists(Vasopressin V2 receptor antagonists)
Therapeutic Areas
Cardiovascular Diseases
Active Indication
Heart FailureEdema, Cardiac
Inactive Indication-
Originator Organization
Otsuka Pharmaceutical Co., Ltd.Otsuka Pharmaceutical Co., Ltd.
Active Organization
Otsuka Pharmaceutical Co., Ltd.Otsuka Pharmaceutical Co., Ltd.Otsuka Pharmaceutical Development & Commercialization, Inc.
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Related

5
Clinical Trials associated with OPC-131461
NCT06795399
/ Not yet recruitingPhase 2
A Phase 2, Randomized, Double-blind, Placebo-controlled, Proof of Concept Trial for OPC-131461 in Patients Hospitalized for Worsening Heart Failure With Laboratory Evidence of Incomplete Decongestion Following Urgent Decongestive Therapy
NCT05615363
/ CompletedPhase 2
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Doseranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure [CHF])
JPRN-jRCT2071220069
/ RecruitingPhase 2IIT
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Doseranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure [CHF])
100 Clinical Results associated with OPC-131461
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100 Translational Medicine associated with OPC-131461
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100 Patents (Medical) associated with OPC-131461
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100 Deals associated with OPC-131461
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart FailurePhase 2-
Otsuka Pharmaceutical Development & Commercialization, Inc.
26 Feb 2025
Edema, CardiacPhase 2
JP
Otsuka Pharmaceutical Co., Ltd.Otsuka Pharmaceutical Co., Ltd.
10 Jan 2023
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Clinical Result

Indication
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Clinical Trial

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Approval

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Regulation

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