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Last update 19 Feb 2025
Nesuparib
Last update 19 Feb 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms JPI 547, JPI-547, NOV 1402 + [4] |
Target |
Mechanism PARP inhibitors(Poly (ADP-Ribose) polymerase inhibitors), TNKS1 inhibitors(tankyrase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
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Structure/Sequence
Molecular FormulaC23H24N6O |
InChIKeyGRPXLKXGJAGYSD-UHFFFAOYSA-N |
CAS Registry2055357-64-5 |
Related
5
Clinical Trials associated with NesuparibNCT06502743
Phase 2 Study of First-line Carboplatin and Paclitaxel in Combination With Pembrolizumab, Followed by Maintenance Pembrolizumab With or Without Nesuparib, in Patients With Newly Diagnosed Advanced or Recurrent MMR-proficient (pMMR) Endometrial Cancer
KCT0009641
Phase 2 study of first-line carboplatin and paclitaxel in combination with pembrolizumab, followed by maintenance pembrolizumab with or without Nesuparib, in patients with newly diagnosed advanced or recurrent MMR-proficient (pMMR) endometrial cancer
NCT05475184
A Multicenter, Open-label, Single-arm, Phase 2 Study to Evaluate the Efficacy and Safety of JPI-547, a PARP/TNKS Dual Inhibitor in Platinum-resistant, Advanced/Relapsed Ovarian Cancer Subjects Previously Treated With a PARP Inhibitor
100 Clinical Results associated with Nesuparib
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100 Translational Medicine associated with Nesuparib
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100 Patents (Medical) associated with Nesuparib
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100 Deals associated with Nesuparib
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Recurrent Endometrial Cancer | Phase 2 | - |  Onconic Therapeutics, Inc.Startup | 01 Aug 2024 |
| Platinum-Resistant Ovarian Carcinoma | Phase 2 | KR | Onconic Therapeutics, Inc.Startup | 31 Aug 2022 |
| Pancreatic Cancer | Phase 2 | KR | - | |
| Metastatic Pancreatic Cancer | Phase 1 | KR | Onconic Therapeutics, Inc.Startup | 30 Mar 2022 |
| Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 | KR | Onconic Therapeutics, Inc.Startup | 30 Mar 2022 |
| Advanced Malignant Solid Neoplasm | Phase 1 | KR | Onconic Therapeutics, Inc.Startup | 06 Dec 2017 |
| Advanced Malignant Solid Neoplasm | Phase 1 | KR | 06 Dec 2017 | |
| Colorectal Cancer | Phase 1 | - | - | |
| Colorectal Cancer | Phase 1 | - | - |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1 | 62 | (dose escalation) | zpyjhwrqpd(bsksxubexa) = mbicvotegt cezkaqholq (okhnjegiow ) View more | Positive | 20 May 2021 | ||
(dose escalation) | vhvkgxmzqv(qocpkptpac) = jemwkadoaz xrlepuqpyr (ukpatlblvy ) View more |
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