PURPOSE OF REVIEWRecent work has added to the understanding of the burden of Campylobacter jejuni, C. coli, and non-jejuni/coli Campylobacter strains in children living in the developing world.RECENT FINDINGSNew diagnostic modalities and carefully designed field studies are demonstrating that the burden of Campylobacter diarrhea in children in the developing world has been greatly underestimated. Furthermore, there is emerging recognition of an association between Campylobacter infection and malnutrition. Important progress has been made toward a Campylobacter jejuni vaccine. Finally, evidence of antibiotic resistance continues to be an important issue that is accentuated by the realization that the burden of disease is greater than previously recognized.SUMMARYAdditional research is needed to refine our understanding of the epidemiology of Campylobacter infections in developing countries, in particular to improve estimates of the burden of Campylobacter diarrhea in endemic settings, to determine the impact of recurrent Campylobacter infections on child development, and to describe the prevalence and clinical significance of non-jejuni/coli Campylobacter infections. Progressive antibiotic resistance of isolates argues for augmented and expanded control measures of antibiotics in livestock. Continued work in vaccine development is warranted as is the extension of data available on the serotypes related to burden in different areas of the world and the relationship of serotypes to disease severity.

01 May 2009·Expert Review of VaccinesQ2 · MEDICINE

Update onCampylobacter jejunivaccine development for preventing human campylobacteriosis

Q2 · MEDICINE

Review

Author: Agnieszka Wyszyńska ; Paweł Łaniewski ; Elżbieta Katarzyna Jagusztyn-Krynicka

Campylobacteriosis constitutes a serious medical and socioeconomic problem worldwide. Rapidly increasing antibiotic resistance of bacterial strains compels us to develop alternative therapeutic strategies and to search for efficient immunoprophylactic methods. The vast majority of Campylobacter infections in developed countries occur as sporadic cases, mainly caused by eating undercooked Campylobacter-contaminated poultry. The most efficient strategy of decreasing the number of human Campylobacter infections is by implementing protective vaccinations for humans and/or chickens. Despite more than 10 years of research, an effective anti-Campylobacter vaccine has not been developed. This review highlights our increasing knowledge of Campylobacter interaction with host cells and focuses on recently published data describing the efficacy of anti-Campylobacter vaccine prototypes.

100 Deals associated with Campylobacter jejuni vaccine (Emergent BioDefense Operations Lansing)

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Indication	Highest Phase	Country/Location	Organization	Date
Campylobacter Infections	Phase 3	US	Emergent Biodefense Operations Lansing LLC	-
Campylobacter Infections	Phase 2	US	U.S. Army Medical Research Institute for Infectious Diseases	-

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