Increasing the uptake of Human Papillomavirus (HPV) vaccine among adolescent girls is a high priority for the government of Bangladesh. This study examines correlates of HPV vaccine adoption in Dhaka Division, the largest division in Bangladesh. The 18-day vaccination campaign was accompanied by multimedia messages. We use the Fogg Behavior Model (FBM) as the theoretical framework for our analysis. Using a survey instrument based on the FBM, we analyze cross-sectional data collected from 611 caregivers of girls aged 9-17 in Dhaka. Survey data was collected in November and December 2023. Caregivers were recruited via Facebook and Instagram ads and interviewed through the Facebook Messenger App. About one-third of caregivers reported that their child had been vaccinated. We conducted bivariate and multivariate analyses to assess the relationships between the caregivers' motivation, ability, exposure to the campaign and their child's vaccination status. Adjusted odds ratios from logistic regression analyses, suggest that caregivers' motivation, ability, and exposure to the multimedia campaign contributed to vaccine uptake. Caregivers' motivation to get their child vaccinated was high (74%) but their ability was low (20%). Exposure to campaign messages had a dose-response relationship with vaccine adoption. However, 48% of caregivers remained unexposed to the multimedia campaign. We discuss challenges that the government's HPV vaccination program is likely to face and identify program-related research questions that are important to answer for the success of future vaccination efforts.

31 Dec 2025·Human Vaccines & Immunotherapeutics

Human papillomavirus (HPV) vaccine clinical trials: A cross-sectional analysis of clinical trials registries

Article

Author: Ndwandwe, Duduzile ; Mmotsa, Tshiamo Moshading ; Mavundza, Edison Johannes

Clinical trials remain the gold standard for evaluating the effectiveness and safety of health interventions. Every clinical trial is mandated to be registered prospectively in a publicly accessible trial registry before the enrollment of the first participant. The aim of the current study was to provide a cross-sectional analysis of registered HPV vaccine clinical trials listed in the International Clinical Trials Registry Platform (ICTRP). On 05 March 2023, we searched the ICTRP for registered HPV vaccine clinical trials using the term "human papillomavirus vaccine." Two authors independently extracted data including the name of the clinical trial registry, location, recruitment status, gender of participants, phase, primary outcome, and type of sponsor. Our search of the ICTRP resulted in 437 HPV vaccine clinical trials registered between 1999 and 2022. Most of the trials were: registered retrospectively (61.3%, n = 268), registered in ClinicalTrials.gov registry (66.8%, n = 292), conducted in Europe (26.0%, n = 112), not recruiting (80.5%, n = 352), in phase 3 (37.3%, n = 163), conducted among female participants (64.3%, n = 281), studying immune responses (46.7%, n = 204), and sponsored by pharmaceutical companies (50.3%, n = 220). To increase research transparency, prevent duplication of research, and prevent publication bias, there is an urgent need for all primary registries to make prospective registration mandatory and remain the only type of registration available to trial sponsors. All clinical trial primary registries should also make the completion of all fields compulsory when registering a trial to improve transparency.

01 Jul 2025·International Journal of Nursing Studies

Strategies used by healthcare professionals to increase the human papillomavirus vaccine uptake among adolescents in Ireland: A qualitative study

Article

Author: Markey, Kathleen ; Sackey, Margaret Efua ; Grealish, Annmarie

BACKGROUNDAdolescent human papillomavirus vaccine uptake in Ireland dropped to 50-60 % between 2016 and 2021. Healthcare professionals play a vital role in increasing the uptake of human papillomavirus vaccine among adolescents. This is the first study that sought to identify the key opportunities for healthcare professionals to get adolescent vaccination uptake to optimal rate.OBJECTIVETo explore the strategies healthcare professionals in Ireland use to promote vaccine uptake among adolescents and to understand how they are addressing vaccine hesitancy.DESIGNA qualitative descriptive study.SETTING(S)Three community health organisations in Ireland.PARTICIPANTSA purposive sample of 17 healthcare professionals involved in the delivery of the human papillomavirus vaccination programme in Ireland was recruited.METHODSSemi-structured interviews were conducted between November 2022 and July 2023. Reflexive thematic analysis method was used to analyse the interview data.RESULTSFour themes emerged from the data: Attitudes towards the human papillomavirus vaccine; Strategies used to promote the vaccine's uptake; Organisational and structural enablers and barriers; and Future improvement strategies. Healthcare professionals reported that there are still concerns about the safety and efficacy of human papillomavirus vaccine especially among marginalised populations. Healthcare professionals reported that increased uptake was more likely if they adopted flexible approaches to delivering the vaccine, easily accessible drop-in clinics, and proving more opportunities to educate adolescents and parents about the importance of the vaccine. Despite these efforts, healthcare professionals are faced with organisational barriers that hinder effective delivery. Policy reform to support and educate stakeholders could improve the vaccine uptake. In addition, more work is needed to address unproven negative testimonies on social media, to reduce concerns among the public regarding the safety and potential side effects of the vaccine.CONCLUSIONSHuman papillomavirus vaccine is one of the best preventative measures that public health care has to offer in preventing and reducing human papillomavirus related cancers and infections. Healthcare professionals demonstrated several interventions they adopt to improve the uptake of the human papillomavirus vaccine for adolescents. The findings suggest that adopting better multi-setting approaches to vaccination programmes and multi-system collaborative efforts would significantly increase the uptake of the vaccine.TWEETABLE ABSTRACTStrategies used by healthcare professionals to increase the human papillomavirus vaccine uptake among adolescents in Ireland.

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Indication	Highest Phase	Country/Location	Organization	Date
Human Papillomavirus Infection	Discovery	Ireland	PHion Therapeutics Ltd.	-

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