Last update 20 May 2025

SMARCA2/4 degrader(Prelude Therapeutics)

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms-
Target
SMARCA2 x SMARCA4
Action
degraders, inhibitors
Mechanism
SMARCA2 degraders(Probable global transcription activator SNF2L2 degraders), SMARCA4 inhibitors(Transcription activator BRG1 inhibitors)
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases+ [1]
Active Indication
Marginal Zone B-Cell Lymphoma
Inactive Indication-
Originator Organization
Institute of Oncology ResearchInstitute of Oncology ResearchPrelude Therapeutics, Inc.Prelude Therapeutics, Inc.Istituto Europeo di Oncologia SrlIstituto Europeo di Oncologia Srl
Active Organization
Institute of Oncology ResearchInstitute of Oncology ResearchPrelude Therapeutics, Inc.Prelude Therapeutics, Inc.Istituto Europeo di Oncologia SrlIstituto Europeo di Oncologia Srl
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Related

100 Clinical Results associated with SMARCA2/4 degrader(Prelude Therapeutics)
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100 Translational Medicine associated with SMARCA2/4 degrader(Prelude Therapeutics)
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100 Patents (Medical) associated with SMARCA2/4 degrader(Prelude Therapeutics)
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100 Deals associated with SMARCA2/4 degrader(Prelude Therapeutics)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Marginal Zone B-Cell LymphomaPreclinical
United States
Prelude Therapeutics, Inc.Prelude Therapeutics, Inc.
27 Apr 2025
Marginal Zone B-Cell LymphomaPreclinical
Italy
Istituto Europeo di Oncologia SrlIstituto Europeo di Oncologia Srl
27 Apr 2025
Marginal Zone B-Cell LymphomaPreclinical
Switzerland
Institute of Oncology ResearchInstitute of Oncology Research
27 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Approval

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Regulation

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