Delving into the Latest Updates on Phleum pratense pollen allergy immunotherapy(HAL Allergy Holding BV) with Synapse

Overview

Basic Info

Drug Type

Allergen extract

Synonyms

Phleum pratense pollen allergy vaccine, SUBLIVAC FIX Phleum pratense, Sublivac Fix Grasses

Target-

Action

modulators

Mechanism

Immunomodulators

Therapeutic Areas

Immune System DiseasesInfectious DiseasesEye Diseases+ [3]

Active Indication-

Inactive Indication

Originator Organization

HAL Allergy Holding BV

Active Organization-

Inactive Organization

HAL Allergy Holding BV

HAL Allergy BV

Drug Highest PhasePendingPhase 3

First Approval Date-

Regulation-

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The purpose of this study is to assess safety, tolerability and demonstrate a dose response signal using Total Symptom Score (TSS), based on challenges with grass pollen in an Environmental Exposure Chamber (EEC), followed by estimation of the minimum effective dose of SUBLIVAC FIX Phleum (SP) after 10 months of treatment compared to placebo.
The study has 4 treatment groups: 3 different doses of SP and placebo will be tested.

Start Date01 Sep 2015

Sponsor / Collaborator

HAL Allergy Holding BV

EUCTR2010-021235-13-DE

/ Not yet recruitingNot Applicable

A randomized, double-blind, placebo-controlled study to determine safety, tolerability and the optimal effective dose of SUBLIVAC FIX Phleum pratense in patients with allergic rhinitis/rhinoconjunctivitis caused by grass pollen - SUBLIVAC FIX Phleum pratense DT/DRF

Start Date04 Sep 2012

Sponsor / Collaborator-

NCT01682070

/ CompletedPhase 2

A Randomized, Double-blind, Placebo-controlled Study to Determine Safety, Tolerability and the Optimal Effective Dose of SUBLIVAC FIX Phleum Pratense in Patients With Allergic Rhinitis/Rhinoconjunctivitis Caused by Grass Pollen

The aim of the study is to determine the optimal effective dose of SUBLIVAC FIX Phleum pratense based on reduction of upper airways reactivity after 5 months of treatment with different dosages of SUBLIVAC FIX Phleum pratense compared to placebo. Furthermore, safety and tolerability will be assessed by the number of related Adverse Events of different dosages of SUBLIVAC FIX Phleum pratense compared to placebo.

Start Date01 Sep 2012

Sponsor / Collaborator

HAL Allergy Holding BV

100 Clinical Results associated with Phleum pratense pollen allergy immunotherapy(HAL Allergy Holding BV)

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100 Translational Medicine associated with Phleum pratense pollen allergy immunotherapy(HAL Allergy Holding BV)

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100 Patents (Medical) associated with Phleum pratense pollen allergy immunotherapy(HAL Allergy Holding BV)

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100 Deals associated with Phleum pratense pollen allergy immunotherapy(HAL Allergy Holding BV)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Conjunctivitis, Allergic	Phase 3	Poland	HAL Allergy Holding BV	01 Sep 2006
Conjunctivitis, Allergic	Phase 3	Germany	HAL Allergy Holding BV	01 Sep 2006
Conjunctivitis, Allergic	Phase 3	Belgium	HAL Allergy Holding BV	01 Sep 2006
Conjunctivitis, Allergic	Phase 3	Netherlands	HAL Allergy Holding BV	01 Sep 2006
Rhinitis, Allergic, Seasonal	Phase 3	Belgium	HAL Allergy Holding BV	01 Sep 2006
Rhinitis, Allergic, Seasonal	Phase 3	Netherlands	HAL Allergy Holding BV	01 Sep 2006
Rhinitis, Allergic, Seasonal	Phase 3	Poland	HAL Allergy Holding BV	01 Sep 2006
Rhinitis, Allergic, Seasonal	Phase 3	Germany	HAL Allergy Holding BV	01 Sep 2006
Rhinitis, Allergic	Phase 3	Germany	HAL Allergy BV	-
Rhinitis, Allergic	Phase 3	Poland	HAL Allergy BV	-

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Clinical Result

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Biosimilar

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