Last update 30 Oct 2025

RG-6421

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GDC-6988, RG6421
Target
ANO1
Action
stimulants
Mechanism
ANO1 stimulants(anoctamin 1 stimulants)
Therapeutic Areas
Infectious DiseasesRespiratory DiseasesCongenital Disorders+ [2]
Active Indication
Bronchitis, ChronicNon-cystic fibrosis bronchiectasisCystic Fibrosis
Inactive Indication-
Originator Organization
Genentech, Inc.Genentech, Inc.
Active Organization
Genentech, Inc.Genentech, Inc.
Inactive Organization-
License Organization
Enterprise Therapeutics Ltd.Enterprise Therapeutics Ltd.
Roche Holding AGRoche Holding AG
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with RG-6421
NCT06603246
/ RecruitingPhase 1
A Phase Ic, Open-Label, Multicenter Study to Evaluate the Safety, Tolerability, and Activity of Inhaled GDC-6988 in Patients With Muco-Obstructive Disease
100 Clinical Results associated with RG-6421
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100 Translational Medicine associated with RG-6421
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100 Patents (Medical) associated with RG-6421
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100 Deals associated with RG-6421
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bronchitis, ChronicPhase 1
United States
Genentech, Inc.Genentech, Inc.
18 Nov 2024
Non-cystic fibrosis bronchiectasisPhase 1
United States
Genentech, Inc.Genentech, Inc.
18 Nov 2024
Cystic FibrosisPhase 1
United States
Genentech, Inc.Genentech, Inc.
24 May 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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