Delving into the Latest Updates on Felbinac Trometamol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Binaprofen, Felbinac, 万舒安

Target

COXs

Action

inhibitors

Mechanism

COX inhibitors(Cyclooxygenases inhibitors)

Therapeutic Areas

Nervous System DiseasesOther DiseasesDigestive System Disorders+ [1]

Active Indication

Pain, PostoperativePainRenal Insufficiency+ [1]

Inactive Indication

BlepharitisCalculiCancer Pain+ [13]

Originator Organization

Dalian Tianyu Pharmaceutical Co.,Ltd.

Active Organization

Guangdong Zhongke Pharmaceutical Research Co., Ltd.Dalian Tianyu Pharmaceutical Co.,Ltd.

Hebei Kaiwei Pharmaceutical Co. Ltd.

+ [1]

Inactive Organization-

License Organization

Shijiazhuang Yiling Pharmaceutical Co., Ltd.

Guangdong Zhongke Pharmaceutical Research Co., Ltd.

Drug Highest PhaseNDA/BLA

First Approval Date-

RegulationSpecial Review Project (China)

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Structure/Sequence

Molecular FormulaC14H12O2

InChIKeyQRZAKQDHEVVFRX-UHFFFAOYSA-N

CAS Registry5728-52-9

View All Structures (2)

主要目的：（1）评价氟康唑胶囊对中国健康受试者静脉滴注苯胺洛芬注射液的药代动力学影响；（2）评价利福平胶囊对中国健康受试者静脉滴注苯胺洛芬注射液的药代动力学影响；次要目的：评价健康受试者单剂量静脉滴注苯胺洛芬注射液与口服氟康唑胶囊/利福平胶囊联合用药的安全性。

[Translation]

Primary objectives: (1) To evaluate the effect of fluconazole capsules on the pharmacokinetics of intravenous anilinoprofen injection in healthy Chinese subjects; (2) To evaluate the effect of rifampicin capsules on the pharmacokinetics of intravenous anilinoprofen injection in healthy Chinese subjects; Secondary objectives: To evaluate the safety of single-dose intravenous anilinoprofen injection combined with oral fluconazole capsules/rifampicin capsules in healthy subjects.

Start Date28 Sep 2021

Sponsor / Collaborator

Dalian Tianyu Pharmaceutical Co.,Ltd.

[+1]

CTR20211806

/ CompletedPhase 1

苯胺洛芬滴眼液单中心、随机、双盲、安慰剂对照健康受试者多次给药人体耐受性和药代动力学研究

[Translation] A single-center, randomized, double-blind, placebo-controlled study of the tolerability and pharmacokinetics of fenprofen eye drops in healthy subjects after multiple doses

主要目的：评价苯胺洛芬滴眼液多次给药在中国健康受试者中的安全性和耐受性。次要目的：评价苯胺洛芬滴眼液多次给药在中国健康受试者中的药代动力学特征。

[Translation]

Primary objective: To evaluate the safety and tolerability of multiple-dose anilinoprofen eye drops in healthy Chinese subjects. Secondary objective: To evaluate the pharmacokinetic characteristics of multiple-dose anilinoprofen eye drops in healthy Chinese subjects.

Start Date07 Sep 2021

Sponsor / Collaborator

Guangdong Zhongke Pharmaceutical Research Co., Ltd.

CTR20212131

/ CompletedPhase 1

[14C]苯胺洛芬注射液在中国成年男性健康受试者体内吸收、代谢和排泄临床试验——[14C]苯胺洛芬注射液人体物质平衡与生物转化研究

[Translation] Clinical trial on absorption, metabolism and excretion of [14C]anilinoprofen injection in healthy adult male subjects in China——Study on material balance and biotransformation of [14C]anilinoprofen injection in humans

主要目的：评价中国男性健康受试者单次静脉滴注[14C]苯胺洛芬注射液的物质平衡及生物转化途径。次要目的：评价苯胺洛芬在人体内的药代动力学整体特征及安全性。

[Translation]

Primary objective: To evaluate the material balance and biotransformation pathways of a single intravenous infusion of [14C]anilinoprofen injection in healthy Chinese male subjects. Secondary objective: To evaluate the overall pharmacokinetic characteristics and safety of anilinoprofen in humans.

Start Date01 Sep 2021

Sponsor / Collaborator

Dalian Tianyu Pharmaceutical Co.,Ltd.

[+1]

100 Clinical Results associated with Felbinac Trometamol

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100 Translational Medicine associated with Felbinac Trometamol

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100 Patents (Medical) associated with Felbinac Trometamol

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974

Literatures (Medical) associated with Felbinac Trometamol

01 Mar 2025·Chinese Chemical Letters

Nickel-catalyzed decarboxylative difluoromethylation and alkylation of alkenes

Author: Chen, Hui ; Ai, Zhenkang ; Liao, Xuebin

Herein, we describe a nickel-catalyzed reductive decarboxylative difluoromethylation reaction of alkenes using inexpensive and easy-to-handle difluoroacetic anhydride (DFAA)/pyridine N-oxide reagent system.A variety of C(sp³)-CF₂H containing compounds were prepared through a hydrodifluoromethylation process.Besides, various gem-difluoroalkenes bearing CF₂H group were synthesized via defluorinative reductive cross-coupling process from trifluoromethyl-substituted alkenes using this new reaction system.Difluoroacetic anhydride has been then extended to other common alkyl anhydrides, and the corresponding hydroalkylation and defluoroalkylation processes have been successfully achieved.This method features broad substrate scope, good functional group tolerance as well as high efficiency.

01 Mar 2025·Tetrahedron

4-Aminobenzotriazole directed palladium-catalyzed C–H acetoxylation and intramolecular amination reaction

Author: Li, Yuanming ; Li, Chengqian ; Song, Zhiguang ; Fan, Yupeng ; Hu, Jianliang ; Huang, Wangsheng ; Wang, Zhuo

We present an approach for ortho C(sp²)-H acylation and intramol. amination reactions, employing 4-amino-benzotriazole (ABTA) as a bidentate directing group.This method is facilitated by a palladium catalyst in combination with iodobenzene diacetate.Our approach efficiently yields acetoxylation and intramol. amination products from a variety of acylamide substrates, including arylcarboxamides and arylacetamides.

01 Feb 2025·Tetrahedron

An efficient method for thioesterification of carboxylic acid with sulfenylchloride

Author: Zi, You ; Wang, Mengke ; Chen, Jiahong ; Huang, Weichun

A mild and convenient method for synthesizing thioesters has been developed, from sulfenylchlorides and carboxylic acids via a phosphine mediated umpolung process.This approach efficiently produces a broad spectrum of thioesters from readily available carboxylic acids, including primary, secondary and tertiary types, as well as bioactive mols.The successful gram-scale reactions also validate its scalability and practical application.

100 Deals associated with Felbinac Trometamol

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB07477

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Pain, Postoperative	NDA/BLA	China	Shijiazhuang Yiling Pharmaceutical Co., Ltd.	10 Jul 2024
Pain, Postoperative	NDA/BLA	China	Hebei Kaiwei Pharmaceutical Co. Ltd.	10 Jul 2024
Pain	NDA/BLA	-	Shijiazhuang Yiling Pharmaceutical Co., Ltd.	-
Neuralgia	Discovery	China	Guangdong Zhongke Pharmaceutical Research Co., Ltd.	10 May 2021
Cancer Pain	Discovery	China	Guangdong Zhongke Pharmaceutical Research Co., Ltd.	08 Apr 2021
Cancer Pain	Discovery	China	Dalian Tianyu Pharmaceutical Co.,Ltd.	08 Apr 2021
Gout	Discovery	China	Guangdong Zhongke Pharmaceutical Research Co., Ltd.	08 Apr 2021
Gout	Discovery	China	Dalian Tianyu Pharmaceutical Co.,Ltd.	08 Apr 2021
Lithiasis	Discovery	China	Guangdong Zhongke Pharmaceutical Research Co., Ltd.	08 Apr 2021
Lithiasis	Discovery	China	Dalian Tianyu Pharmaceutical Co.,Ltd.	08 Apr 2021