The Effect of GM-CSF to Preventing Oral Mucositis for Patients With Nasopharyngeal Carcinoma Receiving Radiotherapy: A Single-center, Phase II, Randomized Trial

To evaluate the efficacy of GM-CSF to preventing oral mucositis for patients with nasopharyngeal carcinoma receiving radiotherapy.

Start Date15 Sep 2023

Sponsor / Collaborator

Sun Yat-Sen University

100 Clinical Results associated with GM-CSF(Sun Yat-sen University)

100 Translational Medicine associated with GM-CSF(Sun Yat-sen University)

100 Patents (Medical) associated with GM-CSF(Sun Yat-sen University)

Literatures (Medical) associated with GM-CSF(Sun Yat-sen University)

01 Oct 2024·Molecular Nutrition & Food Research

Garlic Bioconverted by Bacillus subtilis Stimulates the Intestinal Immune System and Modulates Gut Microbiota Composition

Article

Author: Kim, Hae Soung ; Kim, Kwang Bin ; Moon, Sung‐Kwon ; Yu, Hyeonjun ; Kim, Hoon ; Tonog, Genevieve ; Lee, Sanghyun ; Jeong, Hyeleen ; Suh, Hyung Joo

ScopeThis study evaluates the potential of bioconverted garlic ferments (BGFs) to stimulate the intestinal immune system and modulate cecal microbiota composition.Methods and resultsIn vitro, BGF significantly enhances Peyer's patch (PP)‐mediated bone marrow cell proliferation and increases the production of interferon‐gamma (IFN‐γ), granulocyte macrophage‐colony stimulating factor (GM‐CSF), interleukin (IL)‐6, and immunoglobulin A (IgA) but not IL‐4, IL‐5, and immunoglobulin E (IgE). Oral administration of BGF to C3H/HeN mice for 4 weeks significantly increases the GM‐CSF (42.1–45.8 pg mL−1) and IFN‐γ (6.5–12.1 pg mL−1) levels in PP cells. BGF also significantly elevates the levels of tumor necrosis factor‐alpha (TNF‐α, 165.0–236.3 pg mg−1), GM‐CSF (2.4–3.0 ng mg−1), and IFN‐γ (1.5–3.2 ng mg−1) in the small intestinal fluid, and TNF‐α (2.2–3.1 pg mL−1) and IFN‐γ (10.3–0.21.5 pg mL−1) in the mouse serum. Cecal microbial analysis reveals that BGF increases Bacteroidota and Verrucomicrobiota and decreases Actinobacteria and Bacillota at the phylum level in mice. At the genus level, BGF significantly increases the abundance of Fusimonas (250 mg kg−1 BW−1 day−1), Bacteroides (125 and 250 mg kg−1 BW−1 day−1), and Akkermansia (125 mg kg−1 BW−1 day−1) and decreases that of Bifidobacterium (62.5 and 250 mg kg−1 BW−1 day−1) and Limosilactobacillus (125 and 250 mg kg−1 BW−1 day−1).ConclusionThis study provides the first evidence of BGF's ability to modulate the intestinal immune system and gut microbiota, supporting its potential as a novel functional material to enhance gut immunity.

01 Jan 2024·Journal of Immunology Research

Effects of Injectable Solutions on the Quality of Monocyte‐Derived Dendritic Cells for Immunotherapy

Article

Author: Nosomi Taniwaki, Noemi ; Teodoro Da Silva, Laís ; José da Silva Duarte, Alberto ; Mazzilli Ortega, Marina ; de Jesus Mota, Silvia ; Mitsue Namiyama Nishina, Gislene ; Miyuki Oshiro, Telma ; Justamante Handel Schmitz, Gabriela ; Tiaki Tiyo, Bruna

Therapeutic vaccines based on monocyte‐derived dendritic cells have been shown to be promising strategies and may act as complementary treatments for viral infections, cancers, and, more recently, autoimmune diseases. Alpha‐type‐1‐polarized dendritic cells (aDC1s) have been shown to induce type‐1 immunity with a high capacity to produce interleukin‐12p70 (IL‐12p70). In the clinical use of cell‐based therapeutics, injectable solutions can affect the morphology, immunophenotypic profile, and viability of cells before delivery and their survival after injection. In this sense, preparing a cell suspension that maintains the quality of aDC1s is essential to ensure effective immunotherapy. In the present study, monocytes were differentiated into aDC1s in the presence of IL‐4 and GM‐CSF. On day 5, the cells were matured by the addition of a cytokine cocktail consisting of IFN‐α, IFN‐γ, IL‐1β, TNF‐α, and Poly I:C. After 48 hr, mature aDC1s were harvested and suspended in two different solutions: normal saline and Ringer’s lactate. The maintenance of cells in suspension was evaluated after 4, 6, and 8 hr of storage. Cell viability, immunophenotyping, and apoptosis analyses were performed by flow cytometry. Cellular morphology was observed by electron microscopy, and the production of IL‐12p70 by aDC1s was evaluated by ELISA. Compared with normal saline, Ringer’s lactate solution was more effective at maintaining DC viability for up to 8 hr of incubation at 4 or 22°C.

01 Mar 2023·Glia

Elevated granulocyte colony stimulating factor (CSF) causes cerebellar deficits and anxiety in a model of CSF‐1 receptor related leukodystrophy

Article

Author: Khodakhah, Kamran ; Tindi, Jaafar ; DeTure, Michael A. ; Ketchum, Harmony C. ; Chitu, Violeta ; Burghardt, Nesha S. ; Wszolek, Zbignew K. ; Biundo, Fabrizio ; Dickson, Dennis W. ; Shlager, Gabriel G. L. ; Stanley, E. Richard

AbstractColony stimulating factor (CSF) receptor‐1 (CSF‐1R)‐related leukoencephalopathy (CRL) is an adult‐onset, demyelinating and neurodegenerative disease caused by autosomal dominant mutations in CSF1R, modeled by the Csf1r+/− mouse. The expression of Csf2, encoding granulocyte‐macrophage CSF (GM‐CSF) and of Csf3, encoding granulocyte CSF (G‐CSF), are elevated in both mouse and human CRL brains. While monoallelic targeting of Csf2 has been shown to attenuate many behavioral and histological deficits of Csf1r+/− mice, including cognitive dysfunction and demyelination, the contribution of Csf3 has not been explored. In the present study, we investigate the behavioral, electrophysiological and histopathological phenotypes of Csf1r+/− mice following monoallelic targeting of Csf3. We show that Csf3 heterozygosity normalized the Csf3 levels in Csf1r+/− mouse brains and ameliorated anxiety‐like behavior, motor coordination and social interaction deficits, but not the cognitive impairment of Csf1r+/− mice. Csf3 heterozygosity failed to prevent callosal demyelination. However, consistent with its effects on behavior, Csf3 heterozygosity normalized microglial morphology in the cerebellum and in the ventral, but not in the dorsal hippocampus. Csf1r+/− mice exhibited altered firing activity in the deep cerebellar nuclei (DCN) associated with increased engulfment of glutamatergic synapses by DCN microglia and increased deposition of the complement factor C1q on glutamatergic synapses. These phenotypes were significantly ameliorated by monoallelic deletion of Csf3. Our current and earlier findings indicate that G‐CSF and GM‐CSF play largely non‐overlapping roles in CRL‐like disease development in Csf1r+/− mice.

100 Deals associated with GM-CSF(Sun Yat-sen University)

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Indication	Highest Phase	Country/Location	Organization	Date
Nasopharyngeal Carcinoma	Phase 2	CN	Sun Yat-Sen University	15 Sep 2023
Stomatitis	Phase 2	CN	Sun Yat-Sen University	15 Sep 2023

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


SITC2015	Phase 2	Melanoma Adjuvant	62	GM-CSF (3 μg/kg)	nckuhxwbtt(vciyzubhtt) = at a median follow-up of 79 months, this translated into a significantly longer recurrence-free survival (RFS) in the CpG-treated group (p=0.010) jrloagdxrm (qirmovtdil )	Positive	04 Nov 2015
				CpG-B (PF-3512676/CpG7909, 8 mg)

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