Q1 · CROSS-FIELD
Article
Author: Lorenz, Ivo C. ; Ardeshir, Amir ; Ravetch, Jeffrey V. ; Coffey, Lark L. ; Peace, Avery ; Singapuri, Anil ; Stuart, Jackson B. ; Bjorkman, Pamela J. ; Van Rompay, Koen K. A. ; Esswein, Shannon R. ; Usachenko, Jodie ; Keeffe, Jennifer R. ; Jurado, Andrea ; MacDonald, Margaret R. ; Robbiani, Davide F. ; Bournazos, Stylianos ; Agudelo, Marianna ; Nussenzweig, Michel C. ; Kapoor, Tania ; Keesler, Rebekah I. ; Wang, Qiao ; Immareddy, Ramya ; Gazumyan, Anna ; Rice, Charles M. ; Balderes, Paul J. ; Watanabe, Jennifer
SignificanceZika virus (ZIKV) infection during pregnancy can cause fetal abnormalities. Vaccines against ZIKV are under development, but because of potential safety concerns due to disease-enhancing antibodies, and the time required by active immunization to induce protective antibodies, there is a need to explore alternative strategies. Recombinant monoclonal antibodies can be modified to prevent enhancement of infection, and thus could be an efficacious and safe alternative to vaccines to confer rapid protection. We show that prophylactic administration of two engineered antibodies, Z004 and Z021, to pregnant macaques partially protects against fetal neurologic damage and limits vertical transmission of ZIKV.