Delving into the Latest Updates on Diatrizoate Sodium with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Diatrizoate sodium (USP), Sodium Diatrizoate, Sodium amidotrizoate (INN)

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Target-

Action-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication

Contrast agents

Inactive Indication-

Originator Organization

GE Healthcare, Inc.

Active Organization

LUNAN BETTER PHARMACEUTICAL CO.,LTD.

Inactive Organization

GE Healthcare, Inc.

Drug Highest PhaseApproved

First Approval Date

United States (26 Nov 1954),

Contrast agents

Regulation-

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Structure/Sequence

Molecular FormulaC11H9I3N2NaO4

InChIKeyTZLFDYTXCSSIIO-UHFFFAOYSA-N

CAS Registry737-31-5

Although positive oral contrast agents are used for the majority of abdominopelvic CT scans in the United States, the quality of bowel opacification has not been compared between the three major classes of positive oral contrast material (barium sulfate, ionic iodinated contrast material, and non-ionic iodinate contrast material). This is a retrospective single institution study of clinical records to show whether the uniformity of bowel opacification is different between the three main types of positive CT oral contrast material used in the United States (Barium sulfate, Diatrizoate, and Iohexol). The investigators will retrospectively identify 250 patients each who received oral barium sulfate, diatrizoate, and iohexol for CT scanning of the abdomen and pelvis (total 750 patients) and assess the quality of bowel lumen opacification by the positive oral contrast agents.

Start Date01 Sep 2015

Sponsor / Collaborator

The University of California, San Francisco

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100 Clinical Results associated with Diatrizoate Sodium

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100 Translational Medicine associated with Diatrizoate Sodium

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100 Patents (Medical) associated with Diatrizoate Sodium

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1,336

Literatures (Medical) associated with Diatrizoate Sodium

01 May 2025·Water Research

Transport model-based method for estimating micropollutant removal efficiency in riverbank filtration

Article

Author: Madarász, Tamás ; Pándics, Tamás ; Szűcs, Péter ; Erdélyi, Norbert ; Tóth, Andrea ; Vargha, Márta ; Fekete, Eszter ; Gere, Dóra ; Nyiri, Gábor ; Engloner, Attila ; Nagy-Kovács, Zsuzsanna Ágnes

Riverbank filtration is a cost-effective and efficient method for drinking water production, using the natural filtration capacity of the river gravelbed. Removal efficiency for organic micropollutants (OMP) in field studies is generally calculated by comparing the concentrations measured in surface water and in the wells either on the same day or with a shift of fixed time interval, neither of which can account for the variability of surface water quality and travel time in the aquifer. The present study proposes a novel method based on travel time distribution determined by a numerical transport model with a hypothesis that it will provide more reliable estimate for OMP removal. The model was developed for two production sites of Budapest Waterworks, Hungary on Danube River. River water and riverbank filtered well water were sampled regularly for one year (158 samples each) and analysed for 41 OMPs (pesticides, pharmaceutical residues and industrial pollutants). Nineteen pollutants were detected in >50 % of the well water samples. Median removal rates were 4-97 %, while the concentration of five compounds increased in some wells. Removal rates of telmisartan, tramadol, sulfamethoxazole, 4-methyl-benzotriazole, 5-methyl-benzotriazole and desethyl-terbuthylazine correlated negatively to redox potential (|r|=0.456-0.805). Median travel time increased after high flow events resulting in reduced removal of telmisartan, tramadol, 4-methyl-benzotriazole and desethyl-terbuthylazine (|r|= 0.435-0.661). Removal of diatrizoate, iopamidol, tramadol and benzotriazole increased with distance from the shore (148 vs 395 m) by 25 %, 28 %, 8 %, 16 %, respectively. Background groundwater contamination increased pesticide concentration in the wells located in agricultural areas 1.5-5-fold compared to river water. The model-based method gave more consistent results compared to traditional calculations for OMP removal efficiency during the sampling campaign and allowed for estimating the impact of various environmental factors.

01 Mar 2025·Journal of Hazardous Materials

Fluoroquinolone antibiotics trigger selective oxidation in the trace-Cu(II)/peroxydisulfate system: The synergistic effect of dual reactive sites in chemical structure

Article

Author: Chu, Yingying ; Lv, Ruolin ; Zhang, Weiming ; Liu, Jiahang ; Qian, Mengying ; Li, Xiaoyang

Research on transition metal-triggered advanced oxidation processes (TM-AOPs) has primarily focused on the regulation of catalysts and oxidants, but the alternative route that involves utilizing pollutant-derived electrons to enhance TM-AOPs has been largely overlooked. This study presents a case of selective degradation using fluoroquinolone antibiotics, with ofloxacin (OFX) selected as the model pollutant. Under the presence of PDS and trace Cu(II) (10 μM or 0.64 mg/L, below the limit of US drinking water standard), the OFX degradation rate was enhanced by 12.1 times compared to sole PDS oxidation. Notably, the system exhibited high pollutant selectivity and efficient oxidant utilization. Through various experimental methods, Cu(I) was confirmed as a crucial intermediate, while Cu(III) and •OH was identified as the predominant and secondary reactive oxidative species, respectively. The critical role of OFX was proved to be chelating with Cu(II) and facilitating the production of Cu(I). The degradation selectivity of OFX was attributed to the synergy of the chelating and oxidation sites in its chemical structure. Intramolecular single electron transfer occurred between the chelated OFX and Cu(III), leading to the Cu(III) reduction and OFX oxidation on the piperazine nitrogen atom. This study serves as a representative example of a greener pollutant-induced catalytic process based on the utilization of pollutant's electron bank, and offers novel insights into the correlation between a pollutant's chemical structure and its degradation selectivity.

01 Dec 2024·Lasers in Surgery and Medicine

Optical Clearing of Ex Vivo Adipose Tissue

Article

Author: Timoshina, Polina A. ; Maslyakova, Galina N. ; Navolokin, Nikita A. ; Tuchina, Daria K. ; Bucharskaya, Alla B. ; Genina, Elina A. ; Tuchin, Valery V. ; Yanina, Irina Yu.

ABSTRACTObjectivesThe paper focuses on the development of technology of adipose tissue optical clearing using different complex hyperosmotic optical clearing agents and tissue permeability enhancers.MethodsTo quantify optical clearing efficiency, reduced scattering coefficient was estimated from the ex vivo spatially resolved backreflectance measurements using a multi‐distant fiber optical device. Tissue morphology modification was monitored with the help of histological studies.ResultsKinetics and efficiency of the optical clearing were evaluated for ex vivo abdominal fat tissue at action of dimethyl sulfoxide, diatrizoic acid, metrizoic acid, sucrose, and fructose solutions accompanied by tissue permeability enhancers, such as various modes of fractional laser microablation and sonophoresis and their combinations. Histological studies allowed us to find agents that cause minimal morphological changes of the adipose tissue.ConclusionsMaximal optical clearing efficiency of 83.5% was observed for the samples subjected to action of the fructose‐ethanol solution during 90 min in combination with gentle modes of fractional laser microablation and sonophoresis.

100 Deals associated with Diatrizoate Sodium

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