Delving into the Latest Updates on UC-514321 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

Mechanism

STAT3 inhibitors(Signal transducer and activator of transcription 3 inhibitors), STAT5 transcription factor inhibitors(STAT5 transcription factor inhibitors)

Therapeutic Areas

NeoplasmsHemic and Lymphatic Diseases

Active Indication

Acute Myeloid Leukemia

Inactive Indication-

Originator Organization

Beckman Research Institute of The City of Hope

Active Organization

Beckman Research Institute of The City of Hope

Inactive Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Structure

Molecular FormulaC26H35NO5

InChIKeyXNARHFDDQALZPZ-UHFFFAOYSA-N

CAS Registry299420-83-0

Author: Hu, Chao ; Jiang, Xi ; Li, Chenying ; Su, Rui ; Ulrich, Bryan ; Chen, Chih-Hong ; Wunderlich, Mark ; He, Chunjiang ; Cheng, Liting ; Seibel, William ; Huang, Huilin ; Shen, Chao ; Cui, Xiaolong ; Li, Chong ; Nie, Ji ; He, Chuan ; Liu, Paul P ; Zheng, Yi ; Jin, Jie ; Chen, Yuan ; Lu, Jiuwei ; Chen, Jianjun ; Dong, Lei ; Ferchen, Kyle ; Mulloy, James C ; Weng, Hengyou ; Reinhold, William C ; Wang, Yungui ; Tang, Yixuan ; Arnovitz, Stephen ; Qin, Xi ; Zuo, Zhixiang ; Diao, Jiajie ; Skibbe, Jennifer R

AbstractEffective therapy of acute myeloid leukemia (AML) remains an unmet need. DNA methylcytosine dioxygenase Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Through a series of data analysis and drug screening, we identified two compounds (i.e., NSC-311068 and NSC-370284) that selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification, and effectively inhibit cell viability in AML with high expression of TET1 (i.e., TET1-high AML), including AML carrying t(11q23)/MLL-rearrangements and t(8;21) AML. NSC-311068 and especially NSC-370284 significantly repressed TET1-high AML progression in vivo. UC-514321, a structural analog of NSC-370284, exhibited a more potent therapeutic effect and prolonged the median survival of TET1-high AML mice over three fold. NSC-370284 and UC-514321 both directly target STAT3/5, transcriptional activators of TET1, and thus repress TET1 expression. They also exhibit strong synergistic effects with standard chemotherapy. Our results highlight the therapeutic potential of targeting the STAT/TET1 axis by selective inhibitors in AML treatment.

100 Deals associated with UC-514321

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