Randomized Clinical Trial Evaluating the Non-clinical Inferiority of Suppository Transpulmin and Suppository Guaiacol Compared to Transpulmin Syrup in Frames of Productive Cough of Infectious Origin in Pediatric Participants.

This study evaluates the non-inferiority of Suppository Transpulmin and Suppository Guaiacol compared to Transpulmin Syrup in the treatment of cough with secretion of infectious origin in children between two and six years old. One third of participants will receive Suppository Transpulmin, the other one third will receive Suppository Guaiacol and the last one third will receive Transpulmin Syrup.

Start Date05 May 2015

Sponsor / Collaborator

Aché Laboratórios Farmacêuticos SA

100 Clinical Results associated with Guaiacol

100 Translational Medicine associated with Guaiacol

100 Patents (Medical) associated with Guaiacol

19,232

Literatures (Medical) associated with Guaiacol

01 Dec 2025·Tropical Plant Biology

Root-Specific Expression of Anti-Apoptotic Gene AtBAG4 for Engineering Fusarium Wilt Resistance in Banana cv. Rasthali

Author: Sunisha, C. ; Umesha, M. ; Sowmya, H. D. ; Sriram, S. ; Usharani, T. R. ; Chandrashekar, N.

Fusarium oxysporum f. sp. cubense (Foc) is a soil-borne pathogen that severely limits banana yields globally.In the present study, the Rasthali (AAB) banana cultivar was transformed with the Arabidopsis thaliana BAG4 gene, driven by a root-specific promoter, to modulate cell death pathways and induce resistance against the fungal pathogen.Stable transgenic plants were developed by transforming embryogenic cells derived from immature male floral buds.Integration and expression of the gene cassette in transformants were confirmed by Southern blotting and real-time PCR, resp.Stable transgenic banana lines were selected based on their copy number and vigorous growth.The root challenge bioassay of the selected lines showed a vascular discoloration index (VDI) ranging from 8 to 51%, compared to untransformed bananas, which exhibited a 97% VDI.Lines demonstrating tolerance were further micro-propagated for detailed anal.The enzyme activities of superoxide dismutase and peroxidase were higher in transformed lines than control plants.Addnl., the TUNEL assay of the stable transformant line 168 exhibited reduced apoptotic-like features in the roots post-Foc infection.The results indicated that AtBAG4 transgenic Rasthali plants exhibited tolerance to Foc (Race 1) by inhibiting cell death.Therefore, AtBAG4 gene-mediated tolerance in banana cv.Rasthali offers a promising and sustainable approach for the integrated management of Fusarium wilt in bananas.

01 Aug 2025·Journal of Analytical and Applied Pyrolysis

Efficient catalytic hydroconversion of phenolic-rich aromatic compounds from the extraction of coal tar residue to cyclanes over a β/M composite zeolite-supported Ni nanoparticles

Author: Gao, Yong ; Jiang, Zhong-Hao ; Wei, Jian ; Shi, Wen-Ao ; Mao, Ai-Rong ; Bai, Ni ; Lang, Lin ; Wang, Ai-Min ; Kang, Yu-Hong ; Bai, Jin-Jun ; Liu, Hai-Yan ; Zhao, Zi-Long ; Sun, Qing-Qing ; Li, Yan-Jun

The separation of condensed aromatic compounds from coal tar residue (CTR), converted into cyclanes via catalytic hydroconversion (CHC) to produce essential blending components for coal-based jet fuel, represents a significant strategy for enhancing CTR's value.A highly efficient bifunctional catalyst was prepared by loading Ni nanoparticles (NNPs, ca. 10%) on β/MCM-41 composite zeolite (β/M) and denoted as Ni10%@β/M.CTR was sequentially extracted with acetone/carbon disulfide, petroleum ether, and petroleum ether/methanol (5 vol% H2O) to obtain the soluble portion in methanol phase (PEEPM).PEEPM mainly consists of phenols (64.8%) and arenes (18.9%).It was conducted to CHC over Ni10%@β/M at 160°C for 16 h under 5 MPa of an initial hydrogen pressure (IHP) to obtain CHPEEPM.The results indicate that the relative content of cyclanes in CHPEEPM reaches as high as 93.4%.In Ni10%@β/M, abundant defects, hierarchical porous composite zeolite with strong Lewis acid sites and uniformly dispersed NNPs play crucial roles in removing heteroatoms and hydrogenating aromatic rings (ARs), resp.Benzyloxybenzene (BOB) is a model compound with a >C-O- bridge bond and ARs, used to study the catalytic activity of Ni10%@β/M.BOB was completely converted into cyclanes at 160°C for 2 h under 5 MPa IHP.The high yield of polycyclic alkanes is related to the coupling between the active fragments formed after >C-O- cleavage and the main structure.The synergistic transfer of H···H, δ+H···Hδ-, and H+ generated by Ni10%@β/M activation of H2 is key to the hydrogenation of ARs via induced >C-O- bond cleavage, leading to the formation of saturated cyclanes.

01 Jul 2025·Fuel

Mathematical modeling of multi-step kinetics of biomass pyrolysis applied to agave bagasse and char oxidation reactivity

Author: la Cruz Martinez, Alejandro De ; Belandria, Veronica ; Sangare, Diakaridia ; Bostyn, Stephane ; De Steene, Laurent Van ; Moscosa-Santillan, Mario ; Valette, Jeremy

Computational Fluid Dynamics (CFD) modeling was used to investigate the pyrolysis multi-step kinetics of lignocellulosic biomass, focusing on agave bagasse (AB), including drying, devolatilization, and secondary reactions such as tar cracking and the subsequent char gasification reactivity (both heterogeneous and homogeneous reaction).The pyrolysis was carried out between 100 and 1000°C.During this process, the release of non-condensable gases such as H₂, CH₄, CO, and CO₂, as well as the evolution of char and its composition in terms of carbon, hydrogen, oxygen, and ash content, were simulated and validated using a thermogravimetric analyzer (TGA).The simulation results showed that the char produced at temperatures above 700°C primarily consisted of carbon and ash, with values above 72.85 wt% and 12.39 wt%, confirmed by exptl. data.Subsequently, the pyrolysis process was followed by both isothermal and non-isothermal partial oxidation reactions with air.In the non-isothermal oxidation was conducted between 700 and 1000°C, the influence of heating rate on both gaseous and char products was examined, while in the isothermal oxidation was carried out at 850, 900, 950, and 1000°C, the reactivity index and the peak temperature were examined to express the oxidation reactivity.The CFD results show that the reactivity rate of chars increases proportionally from 0.0080 min^-1 at 850°C to 0.0129 min^-1 at 1000°C.The models used for homogeneous and heterogeneous reactions accurately predicted the exptl. results of the evolution of the gas and char products during the oxidation under isothermal and non-isothermal conditions studied.

100 Deals associated with Guaiacol

External Link

KEGG	Wiki	ATC	Drug Bank
D00117	Guaiacol	V	DB11359

R&D Status

Approved

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Indication	Country/Location	Organization	Date
Analgesia	Japan	Neo Pharma Pvt Ltd.	01 Aug 1963
Disinfectants	Japan	Neo Pharma Pvt Ltd.	01 Aug 1963
Sedation	Japan	Neo Pharma Pvt Ltd.	01 Aug 1963
Toothache	-	-	-

Developing

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Indication	Highest Phase	Country/Location	Organization	Date
Glycogen Storage Disease	Discovery	Israel	Golden Heart Flower Ltd.	14 Aug 2023

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