Randomized Clinical Trial Evaluating the Non-clinical Inferiority of Suppository Transpulmin and Suppository Guaiacol Compared to Transpulmin Syrup in Frames of Productive Cough of Infectious Origin in Pediatric Participants.

This study evaluates the non-inferiority of Suppository Transpulmin and Suppository Guaiacol compared to Transpulmin Syrup in the treatment of cough with secretion of infectious origin in children between two and six years old. One third of participants will receive Suppository Transpulmin, the other one third will receive Suppository Guaiacol and the last one third will receive Transpulmin Syrup.

Start Date05 May 2015

Sponsor / Collaborator

Aché Laboratórios Farmacêuticos SA

100 Clinical Results associated with Guaiacol

100 Translational Medicine associated with Guaiacol

100 Patents (Medical) associated with Guaiacol

642

Literatures (Medical) associated with Guaiacol

01 Mar 2025·Talanta

Deep learning-assisted surface-enhanced Raman spectroscopy detection of intracellular reactive oxygen species

Article

Author: Chen, Chao ; Ye, Ming-Jie ; Chen, Hua-Ying ; Li, Da-Wei ; He, Yue ; Wang, Xiao-Yuan ; Qian, Ruo-Can

Realizing the intelligent analysis of the intracellular reactive oxygen species (ROS) is beneficial to quick diagnosis of diseases. Herein, surface-enhanced Raman spectroscopy (SERS) technology was combined with deep learning to establish a smart detection method of intracellular ROS based on neural network to improve the SERS analysis ability. Taking the simultaneous detection of peroxynitrite (ONOO^-) and hypochlorite (ClO^-) as the templates, 4-mercaptophenylboric acid (4-MPBA) and 2-mercapto-4-methoxyphenol (2-MP) molecules were modified on the AuNPs to prepare AuNP/4-MPBA/2-MP nanoprobes. The SERS spectra of AuNP/4-MPBA/2-MP nanoprobes before and after the specific response of ONOO^- and ClO^- were collected to construct a database, and the neural network model for extraction (ENN) and one-dimensional convolutional neural network model (1D-CNN) for quantification were built. The cosine similarity values of ENN model for ONOO^- and ClO^- correlation spectra were 0.997 and 0.995, respectively. In addition, the qualitative and quantitative results of the models were basically consistent with the experimental results. Moreover, the models can accurately extract the SERS response spectral information of ONOO^- and ClO^- and realize their preliminary prediction of concentration in living cells, which has great potential in the high-throughput smart processing and accurate analysis of large-scale complicated SERS data from biological system.

01 Jan 2025·Food Chemistry

Evaluation of passive samplers as a cost-effective method to predict the impact of wildfire smoke in grapes and wines

Article

Author: Wexler, Anthony ; Campbell, Dave ; Wen, Yan ; Rumbaugh, Arran C ; Liang, Chen ; Fang, Hao-Lin ; Khlystov, Andrey ; Rumbaugh, Arran C. ; Son, Yeongkwon ; Wallis, Christopher

Wildfire smoke exposure alters grape composition, potentially resulting in "smoke tainted" wines. This has been correlated with elevated levels of smoke-derived volatile phenols (VPs) in grapes and wines. This work sought to create a predictive tool that could correlate levels of VPs in smoke with concentrations in grapes and wines. Therefore, passive samplers and Cabernet Sauvignon grapes were intentionally exposed to various smoke intensities, and wines were made thereafter. As expected, concentrations of VPs in grapes and wines were positively associated with the intensity of smoke exposure. Interestingly, levels of guaiacol in the passive samplers had a strong positive correlation with concentrations in grapes (R² = 0.9999) and wines (R² = 0.9998). The passive samplers were able to accurately predict guaiacol levels in smoke exposed grapes and wines with percent errors ranging from 0.08 to 11.3 %. These results suggest the capability of passive samplers to act as a monitoring system in vineyards during smoke events.

01 Jan 2025·Food Chemistry

Decoding of the enhancement of saltiness perception by aroma-active compounds during Hunan Larou (smoke-cured bacon) oral processing

Article

Author: Chen, Jiahui ; Cao, Boya ; Zhang, Yuyu ; Pu, Dandan ; Meng, Ruixing ; Xu, Zikang ; Zhang, Lili ; Sun, Baoguo

The enhancement of saltiness induced by odrants perceived from the retronasal cavity during Larou oral processing was analyzed. During the oral processing of Xiangtan Larou, the smoky attribute was the dominant when chewing 0-15 times, followed by the savory (15-24 times) and meaty (24-42 times). Partial least squares analysis predicted 33 aroma compounds from the retronasal cavity significantly (p < 0.05) contributing to the aroma perception. A total of 12 aroma compounds with saltiness-enhancement ability were confirmed by odorant-NaCl mixture model experiments. Results revealed that 2-methoxy-4-vinylphenol (1.00-1000.00 μg/L) had the strongest enhancing effect on saltiness at NaCl (2969.85 mg/L), followed by diallyl sulfide (0.156-2.50 μg/L), 2,5-dimethylthiophene (0.156-50.00 μg/L), 2,6-dimethylphenol (1.00-100.00 μg/L), 2,5-dimethylpyrazine (0.391-50.00 μg/L), and 2,3-butanedione (0.50-100.0 μg/L). The sulfur-containing, nitrogen-containing, and phenolic odorants with savory, roasty, sulfide, meaty or smoky, attributes showed the better ability in saltiness enhancement.

100 Deals associated with Guaiacol

External Link

KEGG	Wiki	ATC	Drug Bank
D00117	Guaiacol	V	DB11359

R&D Status

Approved

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Indication	Country/Location	Organization	Date
Disinfectants	-	-	-
Toothache	-	-	-

Developing

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Indication	Highest Phase	Country/Location	Organization	Date
Glycogen Storage Disease	Discovery	IL	Golden Heart Flower Ltd.	14 Aug 2023

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