The tolerability and pharmacokinetic characteristics of wogonin after a single intravenous injection were studied in healthy volunteers to provide a basis for formulating dosing regimens in Phase Ib clinical trials.

Start Date06 Jun 2018

Sponsor / Collaborator

China Pharmaceutical University

[+1]

100 Clinical Results associated with Wogonin

100 Translational Medicine associated with Wogonin

100 Patents (Medical) associated with Wogonin

1,100

Literatures (Medical) associated with Wogonin

01 Jan 2025·Journal of Ethnopharmacology

Fei-yan-qing-hua decoction exerts an anti-inflammatory role during influenza by inhibiting the infiltration of macrophages and neutrophils through NF-κB and p38 MAPK pathways

Article

Author: Xu, Lirong ; Liu, Hui ; Tang, Chen-Chen ; Zhang, Wei ; Wu, Xiao ; Tang, Chenchen ; Zheng, Yuejuan ; Ye, Xiaolan ; Yang, Xiao-Dong ; Xu, Gui-Hua ; Duan, Nai-Fan ; Xu, Li-Rong ; Huang, Qilin ; Xu, Guihua ; Chen, Xuan ; Ye, Xiao-Lan ; Xu, Yan-Wu ; Hu, You ; Zheng, Yue-Yuan ; Xu, Yanwu ; Duan, Naifan ; Huang, Qi-Lin

ETHNOPHARMACOLOGICAL RELEVANCEFei-Yan-Qing-Hua decoction (FYQHD) is an empirical formula that has shown clinical success in treating community-acquired pneumonia (CAP) for two decades. Influenza viral infection is a significant trigger for severe pneumonia, yet the role of FYQHD in treating influenza remains unclear.AIM OF THE STUDYThis study aimed to assess the potential efficacy of FYQHD in treating influenza viral infection and to elucidate its underlying mechanisms.MATERIALS AND METHODSThe protective effects of FYQHD against influenza were evaluated through survival assessments and pathological analyses. Transcriptomic analysis was performed to identify the genes and pathways influenced by FYQHD in influenza. The anti-inflammatory effects and molecular mechanisms of FYQHD were studied in macrophages stimulated by Toll-like receptor (TLR) 7 ligation in vitro. The key constituents of FYQHD absorbed in mouse sera were identified using untargeted metabolomics, and the anti-inflammatory activity of some of these compounds in macrophages was evaluated using ELISA.RESULTSOur findings demonstrate that FYQHD enhances survival and reduces lung damage in PR8-infected mice, primarily through its anti-inflammatory properties. Lung indexes and organ damage were significantly lower in the PR8 + OSV + FYQHD group compared to the PR8 + OSV group, indicating a potential complementary therapeutic effect of FYQHD and OSV in treating influenza. FYQHD effectively reduced chemokine expression, thereby decreasing the chemotaxis and infiltration of inflammatory monocytes/macrophages and neutrophils in the lungs. The anti-inflammatory effects of FYQHD in macrophages were achieved through the inhibition of NF-κB activation and p38 phosphorylation. The key constituents of FYQHD absorbed in mouse sera were identified, with some, such as wogonin, luteolin, kaempferol, and isorhamnetin, showing anti-inflammatory effects in primary macrophages.CONCLUSIONFYQHD demonstrates protective efficacy against influenza and shows promise as an adjuvant therapeutic agent, particularly when used in combination with antiviral drugs like OSV. The potent anti-inflammatory components within FYQHD provide a basis for further exploration in drug research and development aimed at combating influenza.

01 Jan 2025·Journal of Ethnopharmacology

Exploring the action mechanism and effective components of Yupingfeng powder on influenza based on computational system pharmacology and metabolomics

Article

Author: Yang, Zifeng ; Wang, Kexin ; Li, Runfeng ; Liu, Ya ; Lin, Luping ; Chen, Xiaohong ; Feng, Pei ; Chen, Yaorong ; Xu, Youhua ; Wu, Xiao ; Chen, Ruifeng

ETHNOPHARMACOLOGICAL RELEVANCEYupingfeng powder (YPF) is a classic traditional Chinese medicine prescription with a long history of clinical application. However, there is a consensus on the clinical efficacy of YPF in the prevention and treatment of influenza, the underlying pharmacological mechanisms and functional substances have not been thoroughly investigated.AIM OF THE STUDYThis study aimed to elucidate the functional substances and potential mechanisms of YPF against influenza infections by integrating network analysis, metabolomics, computational system pharmacology, and in vitro experiments.MATERIALS AND METHODSIn this study, the active ingredients, related targets, and potential mechanisms of YPF against influenza were identified through network pharmacology and GEO database mining. Combined with metabolomics to corroborate the results of network pharmacology analysis and construct C-T-P-D-M network. Based on this, the key network motifs (KNM) with significance were predicted by system pharmacology algorithm. Finally, the key components as functional substances in the KNM were validated by the coverage of influenza-causing genes and functional pathways, and in vitro experiments.RESULTSA total of 238 active components and 158 potential target genes intersecting with influenza infection differential genes were screened from YPF. KEGG enrichment analysis indicated that metabolism participated in YPF-provided prevention and treatment on influenza, and metabolomic results further corroborated the significance of the metabolic pathways intervened by YPF included pyruvate metabolism, Valine, leucine and isoleucine degradation, etc. The KNM prediction strategy was computed to include wogonin and isoimperaporin, a group of 48 potential functional components. This functional component group maintained a high degree of consistency with the corresponding C-T network in terms of the coverage of influenza pathogenic genes, and the coverage of functional pathways. Meanwhile, the in vitro results showed that wogonin and isoimperaporin had significant inhibitory effects on inflammation induced by influenza infection, confirming the reliability and accuracy of the KNM prediction strategy.CONCLUSIONYPF against influenza has multi-target and multi-pathway effects, and the underlying mechanisms may be related to metabolism. The pharmacodynamic effects of core components such as wogonin and isoimperaporin on influenza prevention and treatment were confirmed, which represent promising functional candidates for subsequent influenza prevention and treatment, and provide references for the pharmacological and mechanistic analyses of subsequent formulas.

01 Jan 2025·Colloids and Surfaces B: Biointerfaces

The effects of plant flavones on the membrane boundary potential and lipid packing stress

Article

Author: Ostroumova, Olga S ; Malykhina, Anna I. ; Martynyuk, Vera A. ; Efimova, Svetlana S. ; Malykhina, Anna I ; Efimova, Svetlana S ; Martynyuk, Vera A ; Ostroumova, Olga S.

Here we have revealed the effects of different plant flavones on the physicochemical properties of model lipid membranes. We have demonstrated that baicalein increases the boundary potential of membranes composed of phosphatidylcholine, while wogonin does not affect it. Other flavones tested reduce membrane boundary potential, with this ability increasing among scutellarein, chrysin, apigenin, morin, fisetin, and luteolin. Molecular dynamics simulations demonstrate connection of alteration in boundary potential with the preferential orientation of intrinsic flavone dipole moments in membranes. We have also shown that flavones reduce the melting point of phosphatidylcholine, and this ability increases in the series of luteolin, morin, wogonin, scutellarein, apigenin, baicalein, chrysin, and fisetin. The introduction of baicalein, chrysin and fisetin also leads to a significant decrease in the sharpness of the lipid phase transition. We have hypothesized that the localization of flavones in the glycerol backbone or in the C₁-C₈ methylene region of lipid hydrocarbon chains leads to an increase in the area per lipid and, as a consequence, to an expansion of the lipid melting peak. Replacement of neutral phosphatidylcholine with negatively charged phosphatidylserine affects the membrane-modifying activity of flavones which given the externalization of phosphatidylserine on the surface of cancer cells may be crucial in the flavone anticancer effects.

100 Deals associated with Wogonin

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Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Phase 1	CN	China Pharmaceutical University	06 Jun 2018
Neoplasms	Phase 1	CN	Hefei Heyuan Pharmaceutical Technology Co. Ltd.	06 Jun 2018

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