Last update 19 Dec 2025

JZB-32

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Ocriplasmin, 重组人截短型纤溶酶(景泽生物), JZB-32
Target
fibrin
Action
inhibitors
Mechanism
fibrin inhibitors(Fibrin inhibitors)
Therapeutic Areas
Cardiovascular DiseasesEye Diseases
Active Indication
Polypoidal choroidal vasculopathyVitreomacular Adhesion
Inactive Indication-
Originator Organization
Chengdu Zeyan Biotechnology Co., Ltd.
Active Organization
Shanghai Jingze Biotechnology Co., Ltd.Shanghai Jingze Biotechnology Co., Ltd.Chengdu Zeyan Biotechnology Co., Ltd.Chengdu Jingrunze Gene Technology Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with JZB-32
CTR20234091
/ RecruitingPhase 1
一项多中心、开放、单次给药剂量递增的重组人截短型纤溶酶（JZB32）注射液治疗息肉样脉络膜血管病变的 I 期临床试验
[Translation] A multicenter, open-label, single-dose escalation trial of recombinant human truncated plasmin (JZB32) injection in the treatment of polypoidal choroidal vasculopathy in a phase I clinical trial
CTR20201777
/ RecruitingPhase 1
一项单中心、开放、单次给药剂量递增的重组人截短型纤溶酶（JZB32）注射液治疗症状性玻璃体黄斑粘连的I期临床试验
[Translation] A single-center, open-label, single-dose escalation clinical trial of recombinant human truncated plasmin (JZB32) injection in the treatment of symptomatic vitreomacular adhesions
100 Clinical Results associated with JZB-32
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100 Translational Medicine associated with JZB-32
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100 Patents (Medical) associated with JZB-32
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100 Deals associated with JZB-32
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Polypoidal choroidal vasculopathyPhase 1
China
Chengdu Zeyan Biotechnology Co., Ltd.
19 Aug 2024
Polypoidal choroidal vasculopathyPhase 1
China
Chengdu Jingrunze Gene Technology Co., Ltd.
19 Aug 2024
Vitreomacular AdhesionPhase 1
China
Chengdu Zeyan Biotechnology Co., Ltd.
27 Oct 2022
Vitreomacular AdhesionPhase 1
China
Shanghai Jingze Biotechnology Co., Ltd.Shanghai Jingze Biotechnology Co., Ltd.
27 Oct 2022
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Clinical Result

Indication
Phase
Evaluation
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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