100 Clinical Results associated with L-Arginine/L-Histidine/L-Isoleucine/L-Leucine/L-Lysine Hydrochloride/L-Methionine/L-Phenylalanine/L-Threonine/N-Acetyl-L-Tryptophan/L-Valin/Glycine/Glucose

100 Translational Medicine associated with L-Arginine/L-Histidine/L-Isoleucine/L-Leucine/L-Lysine Hydrochloride/L-Methionine/L-Phenylalanine/L-Threonine/N-Acetyl-L-Tryptophan/L-Valin/Glycine/Glucose

100 Patents (Medical) associated with L-Arginine/L-Histidine/L-Isoleucine/L-Leucine/L-Lysine Hydrochloride/L-Methionine/L-Phenylalanine/L-Threonine/N-Acetyl-L-Tryptophan/L-Valin/Glycine/Glucose

Literatures (Medical) associated with L-Arginine/L-Histidine/L-Isoleucine/L-Leucine/L-Lysine Hydrochloride/L-Methionine/L-Phenylalanine/L-Threonine/N-Acetyl-L-Tryptophan/L-Valin/Glycine/Glucose

01 Mar 2024·International Journal of Biological Macromolecules

Bilayer fiber membrane electrospun from polylactic acid/alginate/bromelain and polylactic acid for enhancing the functionality of tea bags

Article

Author: Tao, Jing ; Li, Zheng ; Sun, Jianbin ; Guo, Jing ; Song, Xuecui ; Zhang, Yihang ; Guan, Fucheng

Tea bags have been extensively used in the food industry and daily life as an efficient way to pack tea. However, the large pores of the commercial tea bags not only lead to the inner contents of tea bag susceptible to bacteria and moisture but also result in the faster water infusion which is undesired during tea brewing. In this study, the polylactic acid (PLA)-PLA/sodium alginate (SA)/bromelain (BL) bilayer fiber membrane imitating the asymmetric wetting structure of lotus leaf blades was fabricated to avoid the above disadvantages of commercial tea bag. The PLA/SA/BL skin-core nanofiber membrane which imitating the skin-core structure of lotus leaf stems was first prepared as the hydrophilic and support layer, then a hydrophobic PLA layer was deposited on top via electrospinning. The PLA-PLA/SA/BL bilayer fiber membrane had a breaking strength of 5.5 MPa and started to decompose at 260 °C. Using this bilayer membrane, tea bags were designed with a novel structure where the hydrophobic PLA layer was placed in the same direction. The novel structure endow the those tea bags a slow and directional water transfer property. Therefore, the PLA-PLA/SA/BL bilayer fiber membrane has great potential for applications as tea bags.

23 Jul 2023·Polymers

Design, Synthesis, and Comparison of PLA-PEG-PLA and PEG-PLA-PEG Copolymers for Curcumin Delivery to Cancer Cells.

Article

Author: Aminoroaya, Alireza ; Smith, Bryan R ; Rostami, Neda ; Noei, Hadi ; Ghebleh, Aida ; Gomari, Mohammad Mahmoudi ; Faridghiasi, Farzaneh ; Kumari, Manisha ; Tajiki, Alireza ; Uversky, Vladimir N ; Abdouss, Majid ; Samadzadeh, Meisam ; Heidari, Reza

Curcumin (CUR) has potent anticancer activities, and its bioformulations, including biodegradable polymers, are increasingly able to improve CUR's solubility, stability, and delivery to cancer cells. In this study, copolymers comprising poly (L-lactide)-poly (ethylene glycol)-poly (L-lactide) (PLA-PEG-PLA) and poly (ethylene glycol)-poly (L-lactide)-poly (ethylene glycol) (PEG-PLA-PEG) were designed and synthesized to assess and compare their CUR-delivery capacity and inhibitory potency on MCF-7 breast cancer cells. Molecular dynamics simulations and free energy analysis indicated that PLA-PEG-PLA has a higher propensity to interact with the cell membrane and more negative free energy, suggesting it is the better carrier for cell membrane penetration. To characterize the copolymer synthesis, Fourier transform-infrared (FT-IR) and proton nuclear magnetic resonance (¹H-NMR) were employed, copolymer size was measured using dynamic light scattering (DLS), and their surface charge was determined by zeta potential analysis. Characterization indicated that the ring-opening polymerization (ROP) reaction was optimal for synthesizing high-quality polymers. Microspheres comprising the copolymers were then synthesized successfully. Of the two formulations, PLA-PEG-PLA experimentally exhibited better results, with an initial burst release of 17.5%, followed by a slow, constant release of the encapsulated drug up to 80%. PLA-PEG-PLA-CUR showed a significant increase in cell death in MCF-7 cancer cells (IC₅₀ = 23.01 ± 0.85 µM) based on the MTT assay. These data were consistent with gene expression studies of Bax, Bcl2, and hTERT, which showed that PLA-PEG-PLA-CUR induced apoptosis more efficiently in these cells. Through the integration of nano-informatics and in vitro approaches, our study determined that PLA-PEG-PLA-CUR is an optimal system for delivering curcumin to inhibit cancer cells.

01 Mar 2022·Iranian journal of basic medical sciences

Preparation and in vitro evaluation of injectable formulations of levothyroxine sodium using in situ forming hydrogel temperature-responsive systems based on PLA-PEG-PLA and PLGA-PEG-PLGA triblock copolymers.

Article

Author: Oroojalian, Fatemeh ; Kamali, Hossein ; Khodaverdi, Elham ; Hadizadeh, Farzin ; Movaffagh, Jebraeil ; Rezaeian Shiadeh, Seyedeh Nesa ; Khalili, Bahnaz

ObjectivesRecently, great attention has been paid to developing new drug delivery systems to manage the rate, time, and site of drug release. We aimed to design a novel drug delivery system to support targeted and gradual delivery of levothyroxine sodium.Materials and MethodsThe triblock copolymers of PLA-PEG-PLA and PLGA-PEG-PLGA were constructed using the ring-opening copolymerization method and then purified and characterized by 1H-NMR, DSC, and GPC techniques. The phase transition temperature of the polymers was determined, and levothyroxine sodium stability was investigated in a phosphate-based buffer (pH 7.4). In vitro drug release into the PBS was measured at different concentrations of the triblocks for one month.ResultsThe results of NMR and GPC showed successful fabrication of the copolymers with low molecular weight dispersion and T_g points of -8.19 ^°C and -5.19 ^°C for PLA-PEG-PLA and PLGA-PEG-PLGA, respectively. Stability tests showed that during one month, most of the triblocks' masses degraded at 37 ^°C while levothyroxine sodium remained stable. Initial burst release of the drug in both copolymers is inversely correlated with the concentration of the polymer. Evaluation of drug release for 35 days showed that PLA-PEG-PLA had a slower drug release rate than PLGA-PEG-PLGA.ConclusionConsidering the low initial burst release, as well as continuous and long-term release kinetics of PLA-PEG-PLA and PLGA-PEG-PLGA copolymers, they can be used to gradually deliver levothyroxine sodium, obviating the need for frequent administrations and concerns over drug-food interactions.

100 Deals associated with L-Arginine/L-Histidine/L-Isoleucine/L-Leucine/L-Lysine Hydrochloride/L-Methionine/L-Phenylalanine/L-Threonine/N-Acetyl-L-Tryptophan/L-Valin/Glycine/Glucose

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Indication	Country/Location	Organization	Date
Hypoproteinemia	JP	Otsuka Pharmaceutical Factory, Inc.	07 Mar 2008
Malnutrition	JP	Otsuka Pharmaceutical Factory, Inc.	07 Mar 2008

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Pubmed \| JCI Insight	Not Applicable	Asthma	41	L-citrulline 15g/day	(houitsvsqv) = uezkgteqvo qemevnzkxi (jyywnkudmq, -11 to 132) View more	-	19 Dec 2019

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L-Arginine/L-Histidine/L-Isoleucine/L-Leucine/L-Lysine Hydrochloride/L-Methionine/L-Phenylalanine/L-Threonine/N-Acetyl-L-Tryptophan/L-Valin/Glycine/Glucose

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