Last update 18 Apr 2026

MB-dNPM1-TCR.1(Miltenyi Biomedicine)

Overview

Basic Info

Drug Type
TCR-T Cell therapy
Synonyms
HLA-A*02:01-restricted TCR, MB-DNPM1-TCR.1
Target
NPM1
Action
modulators
Mechanism
NPM1 modulators(Nucleophosmin modulators)
Therapeutic Areas
NeoplasmsHemic and Lymphatic Diseases
Active Indication
Acute myeloid leukemia with mutated NPM1Acute Myeloid Leukemia
Inactive Indication-
Originator Organization
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbH
Active Organization
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbH
National Cancer InstituteNational Cancer Institute
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with MB-dNPM1-TCR.1(Miltenyi Biomedicine)
NCT06424340
/ RecruitingPhase 1/2
A Phase I/II Trial of MB-dNPM1-TCR.1 in HLA-A*02:01-positive Patients With Relapsed or Refractory NPM1-mutated AML to Determine Safety and Obtain First Data on Efficacy
100 Clinical Results associated with MB-dNPM1-TCR.1(Miltenyi Biomedicine)
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100 Translational Medicine associated with MB-dNPM1-TCR.1(Miltenyi Biomedicine)
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100 Patents (Medical) associated with MB-dNPM1-TCR.1(Miltenyi Biomedicine)
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100 Deals associated with MB-dNPM1-TCR.1(Miltenyi Biomedicine)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute myeloid leukemia with mutated NPM1Phase 2
Netherlands
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbH
01 Aug 2024
Acute Myeloid LeukemiaPreclinical
Germany
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbH
12 Aug 2022
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Deal

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Clinical Trial

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Approval

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Regulation

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