Last update 21 Dec 2024
Pyrimidine series PROTACs 8(GlaxoSmithKline)
Last update 21 Dec 2024
Overview
Basic Info
Drug Type Proteolysis-targeting chimeras (PROTAC) |
Synonyms 10-[3-[[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]amino]methyl]-2,5-difluorophenoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]decanamide |
Target |
Mechanism JAK1 inhibitors(Tyrosine-protein kinase JAK1 inhibitors), JAK2 inhibitors(Tyrosine-protein kinase JAK2 inhibitors) |
Therapeutic Areas- |
Active Indication- |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePreclinical |
First Approval Date- |
Regulation- |
Structure
Molecular FormulaC38H42ClF2N9O5 |
InChIKeyPFLXRQOVRXRBAX-UHFFFAOYSA-N |
CAS Registry2561411-41-2 |
R&D Status
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