[Translation] A multicenter, randomized, double-blind, dose-finding, and active-controlled phase II clinical trial to investigate the efficacy, safety, and PK characteristics of CZ1S transverse abdominal plane block for postoperative analgesia in subjects undergoing colorectal resection
主要目的:
评估和比较注射用CZ1S腹横肌平面(TAP)阻滞用于结直肠切除受试者术后镇痛的有效性。
次要目的:
评估和比较注射用CZ1S和盐酸罗哌卡因腹横肌平面阻滞(TAP)用于结直肠切除受试者术后镇痛的安全性。
评估和比较注射用CZ1S和盐酸罗哌卡因腹横肌平面阻滞(TAP)用于结直肠切除受试者中的药代动力学(PK)特征。
[Translation] Primary objective:
To evaluate and compare the effectiveness of CZ1S injection transverse abdominis plane (TAP) block for postoperative analgesia in subjects undergoing colorectal resection.
Secondary objective:
To evaluate and compare the safety of CZ1S injection and ropivacaine hydrochloride transverse abdominis plane (TAP) block for postoperative analgesia in subjects undergoing colorectal resection.
To evaluate and compare the pharmacokinetic (PK) characteristics of CZ1S injection and ropivacaine hydrochloride transverse abdominis plane (TAP) block in subjects undergoing colorectal resection.