Delving into the Latest Updates on SC-114 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

PPIB

Action

inhibitors

Mechanism

PPIB inhibitors(Cyclophilin B inhibitors)

Therapeutic Areas

Immune System Diseases

Active Indication-

Inactive Indication

Autoimmune DiseasesGraft Rejection

Originator Organization

Scotia

Active Organization-

Inactive Organization

ScotiaScotia Holdings Plc

License Organization-

Drug Highest PhaseDiscontinuedPhase 2

First Approval Date-

Regulation-

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Author: Femenella, Brianna ; Awad, Thomas T. ; Bogardus, Molly F. ; Gallagher, Hannah M. ; Sheridan, Abigail K. ; Razi, Mishal ; Buono, Meredith G. ; Zuchowski, Grace E. ; Touchette, Katie L. ; McLoon, Anna L. ; Thibault, Righlee J. ; Devine, Kaitlyn A. ; Morelock, Laura A. ; Draper, Rebecca M. ; Rennick, Jacqueline R.

Here, we report draft genome sequences of Bacillus pseudomycoides SC107, Rossellomorea sp. SC111, Peribacillus frigoritolerans SC112, Priestia megaterium SC114, Paenibacillus sp. SC116, and Lysinibacillus fusiformis SC117, isolated from a campus wooded area in Loudonville, NY. Genomes were sequenced using the Illumina NextSeq system. The genomes range between 4,381,526 and 6,065,181 bp with GC contents between 35.33% and 43.46%.

18 Jul 1996·Oncogene

Testing NF-kappa B1-p50 antibody specificity using knockout mice.

Article

Author: Graham, F L ; Kushner, D B ; Ricciardi, R P ; Pereira, D S

Cell extracts from knockout mice can provide definitive proof of antibody specificity. Two NF-kappa B1-p50 antibodies, sc-114 (a commercial antibody) and NR1157, were observed to recognize proteins having distinct electrophoretic mobilities of 52-55 kD and 50 kD, respectively, by Western blot analysis. In order to discriminate the specificity of these antibodies for NF-kappa B1-p50, whole cell extracts derived from NF-kappa B1-p105 knockout mice were employed. While the NR1157 antibody completely failed to recognize its 50 kD product in p105-/- knockout extracts, the sc-114 antibody still strongly recognized its 52-55 kD product. These data demonstrate that NR1157, but not sc-114, is highly specific for NF-kappa B1-p50 by Western blot analysis. In addition, these results highlight the utility of knockout cell extracts for discerning antibody specificity.

100 Deals associated with SC-114

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