Delving into the Latest Updates on Docosanol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

1-Docosanol, Abrax, Behenic alcohol

+ [18]

Target

Viral fusion proteins

Mechanism

Viral fusion proteins inhibitors

Therapeutic Areas

Infectious DiseasesSkin and Musculoskeletal Diseases

Active Indication

Herpes Simplex

Inactive Indication

Herpes Labialis

Originator Organization

GSK Plc

Active Organization

Haleon US Capital LLCGlaxoSmithKline Consumer Healthcare Ltd.

Inactive Organization

Laboratoire Boreaderme Inc.

Drug Highest PhaseApproved

First Approval Date

US (25 Jul 2000),

Herpes Simplex

Regulation-

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Structure

Molecular FormulaC22H46O

InChIKeyNOPFSRXAKWQILS-UHFFFAOYSA-N

CAS Registry661-19-8

Recurrent cold sores - herpes simplex labialis (HSL) occurs in 20-40% of the US population and patient seek treatment because of the discomfort and visibility of the lesion although it is a self limiting disease. The purpose of this study is to check the safety, Efficacy and convenience of Use of the Natural Agent "Superlysin Gel" as Treatment for Herpes Labialis in Comparison to Acyclovir 5% and Docozanole 10%.

Start Date-

Sponsor / Collaborator

Hadassah University Hospital

NCT03977792 / Unknown statusPhase 2

A Randomized, Open Label, Non-inferiority Study to Compare the Safety and Efficacy of BOR15001L7 to Docosanol 10% in Patients With Recurrent Herpes Labialis

BOR15001L7 is a natural product. The primary objective of this study is to demonstrate its non-inferiority to docosanol 10% based on the healing time of cold sores in patients with recurrent herpes labialis.

Start Date01 Sep 2020

Sponsor / Collaborator

Laboratoire Boreaderme Inc.

100 Clinical Results associated with Docosanol

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100 Translational Medicine associated with Docosanol

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100 Patents (Medical) associated with Docosanol

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109

Literatures (Medical) associated with Docosanol

01 Oct 2024·iScience

Behenic acid alleviates inflammation and insulin resistance in gestational diabetes mellitus by regulating TLR4/NF-κB signaling pathway

Article

Author: Liu, Kerong ; Cheng, Jie ; Zhang, Le ; Gu, Ying ; Chen, Sha ; Cao, Minkai ; Pan, Xingnan

Gestational diabetes mellitus (GDM) is a distinct form of diabetes that poses a significant threat to the health of both pregnant women and fetuses. The objective of this study was to investigate the impact of behenic acid (BA) on glucose metabolism, inflammation, and insulin resistance in GDM mice, and to elucidate the underlying molecular mechanism. Here, we demonstrated that daily administration of 10 mg/mL BA during pregnancy effectively ameliorated abnormal glucose metabolism in GDM mice and their offspring and improved birth outcomes in the offspring. Moreover, BA promoted the proliferation of islet β cells, restored their normal function, and augmented glucose uptake by skeletal muscle cells. Mechanistically, BA mitigated inflammation and insulin resistance in GDM mice by inhibiting activation of the TLR4/NF-κB signaling pathway. Our study provides compelling evidence supporting the efficacy of BA in improving GDM, suggesting its potential use as a dietary supplement for preventing and treating GDM.

01 Oct 2024·International Journal of Biological Macromolecules

Flexible, breathable, and durable superhydrophobic cotton fabric modified by behenic acid, tung oil, and ZIF-8 with anti-icing and self-cleaning properties

Article

Author: Xing, Tieling ; Yuan, Hua-Bin ; Wang, Jiapeng ; Zhao, Manman ; Chen, Zhong ; Chen, Guoqiang

Textiles with self-cleaning and anti-icing capabilities in cold climates are essential for outdoor workers and enthusiasts. Superhydrophobic modification of textile surfaces is effective in imparting these characteristics. Although there are numerous methods available for manufacturing superhydrophobic textiles, careful consideration is warranted for environmental concerns over fluorochemicals, stability of superhydrophobic coatings, and fabric breathability. In this work, we utilized biomass resources such as tung oil and behenic acid, along with zeolitic imidazolate framework (ZIF-8), to modify cotton fabrics, thereby creating an innovative behenic acid/tung oil/ZIF-8 modified cotton (BTZC) fabric with anti-icing and self-cleaning features. This material manifests a unique nanoflower-shaped surface morphology, demonstrating exceptional superhydrophobicity with a static water contact angle (CA) of 162° and a sliding angle (SA) of 2°. Moreover, BTZC excels in its thermal stability, breathability, and resistance to icing. Equally impressive is its robust stability, as evidenced through rigorous testing under continuous washing and abrasion, sustained high and low temperatures, extreme pH environments, and immersion in various chemical solvents. BTZC presents as a fluorine-free, durable, economically viable alternative for outdoor textile applications, marking substantial progress in the utilization of biomass and metal-organic framework materials in the textile industry and promising implications for value enhancement.

01 Sep 2024·The Journal of nutrition, health and aging

Discovering the direct relations between nutrients and epigenetic ageing

Article

Author: Horvath, Steve ; de Groot, Lisette ; Behrouzi, Pariya ; Yang, Bo ; Liu, Simin ; Biemans, Ynte ; Bach, Daimy ; Manson, JoAnn E ; Grootswagers, Pol ; Whitsel, Eric ; Stewart, James D ; Kramer, Charlotte S ; Shadyab, Aladdin H

BACKGROUNDAlong with the ageing of society, the absolute prevalence of age-related diseases is expected to rise, leading to a substantial burden on healthcare systems and society. Thus, there is an urgent need to promote healthy ageing. As opposed to chronological age, biological age was introduced to accurately represent the ageing process, as it considers physiological deterioration that is linked to morbidity and mortality risk. Furthermore, biological age responds to various factors, including nutritional factors, which have the potential to mitigate the risk of age-related diseases. As a result, a promising biomarker of biological age known as the epigenetic clock has emerged as a suitable measure to investigate the direct relations between nutritional factors and ageing, thereby identifying potential intervention targets to improve healthy ageing.METHODSIn this study, we analysed data from 3,969 postmenopausal women from the Women's Health Initiative to identify nutrients that are associated with the rate of ageing by using an accurate measure of biological age called the PhenoAge epigenetic clock. We used Copula Graphical Models, a data-driven exploratory analysis tool, to identify direct relationships between nutrient intake and age-acceleration, while correcting for every variable in the dataset.RESULTSWe revealed that increased dietary intakes of coumestrol, beta-carotene and arachidic acid were associated with decelerated epigenetic ageing. In contrast, increased intakes of added sugar, gondoic acid, behenic acid, arachidonic acid, vitamin A and ash were associated with accelerated epigenetic ageing in postmenopausal women.CONCLUSIONOur study discovered direct relations between nutrients and epigenetic ageing, revealing promising areas for follow-up studies to determine the magnitude and causality of our estimated diet-epigenetic relationships.

100 Deals associated with Docosanol

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