Last update 26 Jul 2025

Monoclonal antibody BIS-1(University of Groningen)

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms-
Target
CD3 x EpCAM
Action
stimulants, inhibitors
Mechanism
CD3 stimulants(T cell surface glycoprotein CD3 stimulants), EpCAM inhibitors(Epithelial cell adhesion molecule inhibitors), Immunostimulants
Therapeutic Areas
NeoplasmsRespiratory DiseasesUrogenital Diseases+ [1]
Active Indication-
Inactive Indication
AscitesKidney NeoplasmsMalignant ascites+ [3]
Originator Organization
University of GroningenUniversity of Groningen
Active Organization-
Inactive Organization
University of GroningenUniversity of GroningenUniversity Healthsystem Consortium FoundationUniversitätsklinikum BonnUniversitätsklinikum Bonn
License Organization-
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-
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Related

100 Clinical Results associated with Monoclonal antibody BIS-1(University of Groningen)
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100 Translational Medicine associated with Monoclonal antibody BIS-1(University of Groningen)
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100 Patents (Medical) associated with Monoclonal antibody BIS-1(University of Groningen)
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100 Deals associated with Monoclonal antibody BIS-1(University of Groningen)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
AscitesPhase 1-
University of GroningenUniversity of Groningen
-
Kidney NeoplasmsPhase 1
Netherlands
Universitätsklinikum BonnUniversitätsklinikum Bonn
-
Malignant ascitesPhase 1
Netherlands
Universitätsklinikum BonnUniversitätsklinikum Bonn
-
Malignant Pleural EffusionPhase 1-
University of GroningenUniversity of Groningen
-
Pleural EffusionPhase 1
Netherlands
University Healthsystem Consortium Foundation
-
Renal Cell CarcinomaPhase 1-
University of GroningenUniversity of Groningen
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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