Eight White Carneau pigeons were trained to discriminate 1.0 or 1.7 mg/kg of cocaine from saline.A fixed number of consecutive key peck responses on one key after the administration of cocaine resulted in 4-s access to mixed grain.The same number of consecutive responses on the other key after saline also produced food.Different doses of cocaine and other drugs were tested to determine their ability to substitute (80% or more responding on the cocaine-appropriate key).The test drugs were selected to determine the selectivity of the cocaine discrimination in pigeons as well the role of different monoamines in mediating this behavioral effect.The drugs included other psychomotor stimulants, antidepressants, clonidine, yohimbine, other dopamine ((1-2-[bis(4-fluoro-phenyl)-methoxy]ethyl)4-3-phenylpropylpiperazine, GBR 12909) and serotonin (5-HT, sertraline) reuptake blockers, a D₁ (SKF 75670), D₂ (quinpirole), and 5-HT_1A (8-hydroxy-2-(di-n-propylamino)tetralin, 8-PH-DPAT) agonist as well as the 5-HT₃ antagonists, MDL 72222, LY 278584 and ondansetron.In addition, prazosin, an α₁ adrenergic antagonist, SCH 23390, a D₁ antagonist; raclopride, a D₂ antagonist and 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine (NAN-190), a putative 5-HT_1A antagonist, were given in combination with cocaine to determine their ability to block the discriminative stimulus (DS) effects of cocaine, i.e., reduce drug-appropriate responding to 20% or less.The psychomotor stimulants, d-amphetamine and d-methamphetamine, completely substituted for cocaine and were similar in potency to each other and cocaine.The antidepressants l-deprenyl, imipramine, tomoxetine and bupropion also occasioned cocaine-appropriate responding.However, only partial substitution was seen with fluoxetine, clonidine, GBR 12909, quinpirole, SKF 75670 and 8-OH-DPAT.Responding occurred primarily on the saline-appropriate key after the administration of yohimbine, sertraline and the 5-HT₃ antagonists.Prazosin, raclopride, SCH 23390 and NAN-190 blocked the DS effects of cocaine.Taken as a whole, these results indicate that the DS effects of cocaine are mediated not only by dopaminergic systems in the pigeon, as has been demonstrated in other species, but also at least in part by noradrenergic systems.Serotonin systems, in contrast, do not appear involved, although the results with fluoxetine, 8-OH-DPAT and NAN-190 warrant further investigation.

100 Deals associated with [18F]FBFP

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Alzheimer Disease	Preclinical	CN	Beijing Normal University	08 May 2017

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

[18F]FBFP

Overview

Basic Info

Structure

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation