Delving into the Latest Updates on Arginine glutamate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

2-amino-5-(diaminomethylideneamino)pentanoic acid, 2-amino-5-guanidino-pentanoic acid, 2-aminoglutaric acid

+ [8]

Target-

Mechanism-

Therapeutic Areas

Other DiseasesNervous System DiseasesDigestive System Disorders+ [1]

Active Indication

HyperammonemiaHepatic Encephalopathy

Inactive Indication

Chronic liver disease

Originator Organization

AY Pharmaceuticals Co Ltd.

Active Organization

Furen Medicines Group Co., Ltd.

AY Pharmaceuticals Co Ltd.

Liaoning Haisco Pharmaceutical Co., Ltd.

Inactive Organization

Jiangsu Yangtze River Pharmaceutical Group Co., Ltd.

Drug Highest PhaseApproved

First Approval Date

JP (18 Nov 1960),

Hyperammonemia

Regulation-

Login to view timeline

Structure

Molecular FormulaC11H23N5O6

InChIKeyRVEWUBJVAHOGKA-WOYAITHZSA-N

CAS Registry4320-30-3

exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction
cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation
to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients

Start Date01 Feb 2004

Sponsor / Collaborator

Les Hopitaux Universitaires de Strasbourg

100 Clinical Results associated with Arginine glutamate

Login to view more data

100 Translational Medicine associated with Arginine glutamate

Login to view more data

100 Patents (Medical) associated with Arginine glutamate

Login to view more data

561

Literatures (Medical) associated with Arginine glutamate

01 May 2024·Journal of Plant Research

Involvement of GLR-mediated nitric oxide effects on ROS metabolism in Arabidopsis plants under salt stress

Article

Author: Sekmen Cetinel, Askim Hediye ; Gokce, Azime ; Turkan, Ismail

AbstractPlant glutamate receptor-like channels (GLRs) play important roles in plant development, immune response, defense signaling and Nitric oxide (NO) production. However, their involvement in abiotic stress responses, particularly in regulating Reactive Oxygen Species (ROS), is not well understood. This study aimed to investigate GLR-mediated NO production on ROS regulation in salt-stressed cells. To achieve this, Arabidopsis thaliana Columbia (Col-0) were treated with NaCl, glutamate antagonists [(DNQX (6,7-dinitroquinoxaline-2,3-dione and AP-5(D-2-amino-5-phosphono pentanoic acid)], and NO scavenger [cPTIO (2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt)]. Salt-stressed plants in combination with DNQX and AP-5 have exhibited higher increase in lipid peroxidation (TBARS), hydrogen peroxide (H2O2) and superoxide radical (O−2) contents as compared to solely NaCl-treated plants. Furthermore, NO and total glutathione contents, and S-nitrosoglutathione reductase (GSNOR) activity decreased with these treatments. AP-5 and DNQX increased the activities of NADPH oxidase (NOX), catalase (CAT), peroxidase (POX), cell wall peroxidase (CWPOX) in salt-stressed Arabidopsis leaves. However, their activities (except NOX) were significantly inhibited by cPTIO. Conversely, the combination of NaCl and GLR antagonists, NO scavenger decreased the activities of ascorbate peroxidase (APX), superoxide dismutase (SOD), glutathione reductase (GR), dehydroascorbate reductase (DHAR) and monodehydroascorbate reductase (MDHAR) resulting in elevated GSSG levels, a low GSH/GSSG ratio, impaired ROS scavenging, excessive ROS accumulation and cell membrane damage. The findings of this study provide evidence that GLR-mediated NO plays a crucial role in improvement of the tolerance of Arabidopsis plants to salt-induced oxidative stress. It helps to maintain cellular redox homeostasis by reducing ROS accumulation and increasing the activity of SOD, GSNOR, and the ASC-GSH cycle enzymes.

01 Feb 2024·Environmental Research

Selective detection of ionic liquid fluorescence probes for visual colorimetry of different metal ions

Article

Author: Liu, Baoyou ; Kang, Kaiming ; Wang, Limin ; Yue, Gang ; Wang, Zhiqiang ; Peng, Zhixiao ; Shi, Lei ; Du, Xiaohan ; Zhang, Xiaojie ; Chen, Shaohua

At present, the fast distinction of different metal ions in pure water media is not only a great challenge, but also drives the protection of water quality in environmental water bodies. In this paper, a novel ionic liquid fluorescent probe Glycolic Acid-L-Arginine (GA-L-Arg) was rationally created and designed through an in-depth study of ionic liquids. It is also used as an innovative multi-ion fluorescent probe for colorimetric detection and separate identification of Fe³⁺ and Co²⁺ in aqueous solutions of various metal ions. GA-L-Arg has excellent water solubility due to the strong hydrophilicity of Glycolic Acid and L-Arginine. The probe showed high sensitivity, extremely significant selectivity, and great pH stability for Fe³⁺ and Co²⁺ in pure water. The GA-L-Arg structure and the mechanism of Fe³⁺ and Co²⁺ detection were analyzed by infrared spectroscopic characterization and quantum chemical calculations. More importantly, the distinct colorimetric partitioning of Fe³⁺ and Co²⁺ was performed by the unique extraction of Fe³⁺ in the presence of the fluorescent probe and buffer solution.

01 Nov 2023·Pflugers Archiv : European journal of physiology

Neural targets of the enteric dopaminergic system in regulating motility of rat proximal colon.

Article

Author: Hashitani, Hikaru ; Nakamori, Hiroyuki

In isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes a dilatation, while the D₁-like receptor antagonist SCH 23390 (SCH) induces a tonic constriction, suggesting that neurally released dopamine tonically stimulates enteric inhibitory efferent neurons. Here, the targets of the enteric dopaminergic neurons were investigated. Cannulated segments of rat proximal colon were bathed in physiological salt solution and luminally perfused with 0.9% saline, while all drugs were applied to the bath. Spatio-temporal maps of colonic motility were constructed from video recordings of peristaltic contractions, and the maximum diameter was measured as an index of colonic contractility. GBR (1 μM)-induced dilatations of colonic segments were prevented by SCH (5 μM), L-nitro arginine (L-NA; 100 μM), a nitric oxide synthase inhibitor, or tetrodotoxin (0.6 μM). In contrast, constrictions induced by a higher concentration of SCH (20 μM) were unaffected by either L-NA or tetrodotoxin. The vasoactive intestinal peptide (VIP) receptor antagonist VIP_10-28 (3 μM) or P2Y₁ receptor antagonist MRS 2500 (1 μM) had no effect on either the GBR-induced dilatation or the SCH-induced constriction. In colonic segments that had been pretreated with 6-hydroxydopamine (100 μM, 3 h) to deplete enteric dopamine, GBR failed to increase the colonic diameter, while SCH was still capable of constricting colonic segments. Enteric dopaminergic neurons appear to project to nitrergic neurons to dilate the proximal colon by activating neuronal D₁-like receptors. In addition, constitutively activated D₁-like receptors expressed in cells yet to be determined may provide a tonic inhibition on colonic constrictions.

100 Deals associated with Arginine glutamate

Login to view more data

External Link

KEGG	Wiki	ATC	Drug Bank
D02397	Arginine glutamate	A05BA01	DB13207

R&D Status

Approved

10 top approved records.

Login

to view more data

Indication	Country/Location	Organization	Date
Hyperammonemia	JP	AY Pharmaceuticals Co Ltd.	18 Nov 1960

Developing

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Hepatic Encephalopathy	Phase 1	CN	Furen Medicines Group Co., Ltd.	13 Nov 2013
Chronic liver disease	Discovery	CN	Jiangsu Yangtze River Pharmaceutical Group Co., Ltd.	12 Apr 2013
Hyperammonemia	Discovery	CN	Jiangsu Yangtze River Pharmaceutical Group Co., Ltd.	12 Apr 2013