Delving into the Latest Updates on JDP-202 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

antihypertensive (JDP)

Target-

Action-

Mechanism-

Therapeutic Areas

Cardiovascular Diseases

Active Indication-

Inactive Indication

Hypertension

Originator Organization

JDP Therapeutics LLC

Active Organization-

Inactive Organization

JDP Therapeutics LLC

Drug Highest PhasePendingDiscovery

First Approval Date-

Regulation-

AbstractPurpose of ReviewTo summarise evidence on both appropriate and inappropriate antihypertensive drug withdrawal.Recent FindingsDeprescribing should be attempted in the following steps: (1) identify patients with several comorbidities and significant functional decline, i.e. people at higher risk for negative outcomes related to polypharmacy and lower blood pressure; (2) check blood pressure; (3) identify candidate drugs for deprescribing; (4) withdraw medications at 4-week intervals; (5) monitor blood pressure and check for adverse events. Although evidence is accumulating regarding short-term outcomes of antihypertensive deprescribing, long-term effects remain unclear.SummaryThe limited evidence for antihypertensive deprescribing means that it should not be routinely attempted, unless in response to specific adverse events or following discussions between physicians and patients about the uncertain benefits and harms of the treatment.PerspectivesClinical controlled trials are needed to examine the long-term effects of deprescribing in older subjects, especially in those with comorbidities, and significant functional decline.

27 Oct 2021·American Journal of HypertensionQ3 · MEDICINE

Commentary on “Lifestyle Interventions Reduce the Need for Guideline-Directed Antihypertensive Medication”

Q3 · MEDICINE

Communications

Author: Karatzi, Kalliopi ; Basdeki, Eirini D ; Protogerou, Athanase D

01 May 2021·Der NervenarztQ4 · MEDICINE

Antihypertensiva in der Psychiatrie

Q4 · MEDICINE

Article

Author: Haen, Ekkehard ; Endres, Katharina ; Schiller, Ernst

100 Deals associated with JDP-202

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