Delving into the Latest Updates on Bone marrow-derived mesenchymal stromal cells(The University of Queensland) with Synapse

Overview

Basic Info

Drug Type

Mesenchymal stem cell therapy

Synonyms

Bone-marrow derived MSCs(The University of Queensland), bone marrow-derived mesenchymal stromal cells(The University of Queensland)

Target-

Action-

Mechanism

Cell replacements

Therapeutic Areas

Immune System Diseases

Active Indication

Allograft Rejection

Inactive Indication

Cardiomyopathy, DilatedCoronary Artery DiseaseIdiopathic cardiomyopathy+ [1]

Originator Organization

The University of Queensland

Active Organization

The University of Queensland

Inactive Organization

Hospital General Universitario Gregorio Marañón

Pharmicell Co., Ltd.

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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This is a Phase 1/2 study to determine the safety and efficacy of allogeneic (third party), bone-marrow derived mesenchymal stromal cells (MSCs) for the treatment of Osteogenesis Imperfecta (OI) Type 3. It will evaluate this by looking at whether there are treatment related infusion reactions, and assessing linear growth rates and bone health, both of which are impaired in patients ages 3-10 with Osteogenesis Imperfecta Type 3. This is a single-site non-randomized clinical trial, that will take place at Children's Healthcare of Atlanta (CHOA) at Egleston and Emory Children's Center.

Start Date01 Feb 2025

Sponsor / Collaborator

Emory University

NCT05288725

/ Unknown statusPhase 1/2IIT

A Study to Evaluate the Safety, and Efficacy of Minimally Manipulated Autologous Bone Marrow Aspirate to Treat Knee Osteoarthritis in Patients

The study is a multicentered, randomized, double-blinded, placebo-controlled study conducted on the unilateral knee of 120 patients. The study compares the effectiveness of an injection of a mesenchymal stem cell preparation from autologous bone marrow aspirate (BMA) to a corticosteroid control for knee osteoarthritis. WOMAC, VAS pain scores, and MRI will be used for assessment. The study will be conducted at 3 sites in the United States.

Start Date01 Aug 2022

Sponsor / Collaborator

Next Generation Regenerative Medicine LLC

ACTRN12620000840987

/ RecruitingPhase 1IIT

Phase I trial on safety and tolerability of bone-marrow derived mesenchymal stromal cells (MSC) for deteriorating COVID-19 pneumonia

Start Date05 May 2020

Sponsor / Collaborator-

100 Clinical Results associated with Bone marrow-derived mesenchymal stromal cells(The University of Queensland)

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100 Translational Medicine associated with Bone marrow-derived mesenchymal stromal cells(The University of Queensland)

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100 Patents (Medical) associated with Bone marrow-derived mesenchymal stromal cells(The University of Queensland)

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100 Deals associated with Bone marrow-derived mesenchymal stromal cells(The University of Queensland)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Liver Cirrhosis, Alcoholic	Phase 3	United States	Pharmicell Co., Ltd.	20 Jun 2019
Coronary Artery Disease	Phase 3	Spain	Hospital General Universitario Gregorio Marañón	31 Mar 2013
Idiopathic cardiomyopathy	Phase 3	Spain	Hospital General Universitario Gregorio Marañón	31 Mar 2013
Cardiomyopathy, Dilated	Phase 3	Spain	Hospital General Universitario Gregorio Marañón	01 Mar 2013
Allograft Rejection	Phase 2	Australia	The University of Queensland	21 Apr 2017

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03818737 (MILES, CTgov)	Phase 3	Osteoarthritis, Knee	475	Bone Marrow Derived MSCs (Bone Marrow Derived MSCs)	uljrykftjz(ynpigxgzxo) = bymifwsrbn vezjqxuuqh (seahozlwns, elzjomxyke - trzfizoejt) View more	-	27 Jul 2023
				Adipose-derived MSCs (Adipose-derived MSCs)	uljrykftjz(ynpigxgzxo) = srkeblkykn vezjqxuuqh (seahozlwns, cwnmswcreu - hzpezwdwlo) View more