Last update 06 Sep 2025

TP53 R248Q TCR-T Cell(Shanghai General Hospital)

Overview

Basic Info

Drug Type
TCR-T Cell therapy
Synonyms
Autologous, engineered T Cells targeting TP53 R248Q(Shanghai General Hospital), TP53 R248Q Mutation-specific TCR-T Cell Therapy(Shanghai General Hospital)
Target
p53
Action
modulators
Mechanism
p53 modulators(Tumor protein p53 modulators)
Therapeutic Areas
NeoplasmsNervous System DiseasesDigestive System Disorders+ [2]
Active Indication
Adenocarcinoma of LungAdvanced Malignant Solid NeoplasmBrain metastases+ [2]
Inactive Indication-
Originator Organization
Shanghai First People's Hospital
Active Organization
Shanghai First People's Hospital
Inactive Organization-
License Organization-
Drug Highest PhaseEarly Phase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with TP53 R248Q TCR-T Cell(Shanghai General Hospital)
NCT06619886
/ Not yet recruitingEarly Phase 1IIT
Early Clinical Study to Evaluate the Safety and Efficacy of TP53 R248Q Mutation-specific TCR-T Cell Therapy for Advanced Solid Tumor
100 Clinical Results associated with TP53 R248Q TCR-T Cell(Shanghai General Hospital)
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100 Translational Medicine associated with TP53 R248Q TCR-T Cell(Shanghai General Hospital)
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100 Patents (Medical) associated with TP53 R248Q TCR-T Cell(Shanghai General Hospital)
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100 Deals associated with TP53 R248Q TCR-T Cell(Shanghai General Hospital)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adenocarcinoma of LungPhase 1
China
Shanghai First People's Hospital
24 Sep 2024
Advanced Malignant Solid NeoplasmPhase 1
China
Shanghai First People's Hospital
24 Sep 2024
Brain metastasesPhase 1
China
Shanghai First People's Hospital
24 Sep 2024
Colorectal CancerPhase 1
China
Shanghai First People's Hospital
24 Sep 2024
Pancreatic adenocarcinomaPhase 1
China
Shanghai First People's Hospital
24 Sep 2024
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Clinical Trial

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Approval

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Regulation

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