Last update 23 Jan 2025

MZ2

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms
VHL-targeting PROTAC analogue 7
Target
BRD4 x VHL
Mechanism
BRD4 degraders(Bromodomain-containing protein 4 degraders), VHL inhibitors(von Hippel-Lindau tumor suppressor inhibitors)
Therapeutic Areas
NeoplasmsHemic and Lymphatic Diseases
Active Indication
Hematologic NeoplasmsSolid tumorNeoplasms
Inactive Indication-
Originator Organization-
Active Organization
Medchemexpress LLCMedchemexpress LLCUniversity Of DundeeUniversity Of Dundee
Inactive Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC51H64ClN9O9S2
InChIKeyLSELSHXLKGXPPF-BOBBFQORSA-N
CAS Registry1797406-70-2

Related

100 Clinical Results associated with MZ2
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100 Translational Medicine associated with MZ2
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100 Patents (Medical) associated with MZ2
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1
Literatures (Medical) associated with MZ2
01 Jan 2025European Journal of Medicinal Chemistry
A novel viscosity sensitive hemicyanine fluorescent dye for real-time imaging of amyloid-β aggregation
100 Deals associated with MZ2
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hematologic NeoplasmsPreclinical
GB
University Of DundeeUniversity Of Dundee
08 Jun 2017
Hematologic NeoplasmsPreclinical
US
Medchemexpress LLCMedchemexpress LLC
08 Jun 2017
Solid tumorPreclinical
GB
University Of DundeeUniversity Of Dundee
08 Jun 2017
Solid tumorPreclinical
US
Medchemexpress LLCMedchemexpress LLC
08 Jun 2017
NeoplasmsPreclinical
US
University Of DundeeUniversity Of Dundee
16 Jun 2015
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Clinical Result

Indication
Phase
Evaluation
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Approval

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Regulation

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