Delving into the Latest Updates on [18F]T-401 with Synapse

Overview

Basic Info

Drug Type

Chemical drugs, Diagnostic radiopharmaceuticals

Synonyms-

Target

MAGL

Action

inhibitors

Mechanism

MAGL inhibitors(Monoglyceride lipase inhibitors)

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Celgene Corp.

Active Organization

Celgene Corp.

Inactive Organization-

License Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

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A Phase 1, Open-label, Multi-part Positron Emission Tomography (PET) Imaging Study to Evaluate the Biodistribution and Radiation Dosimetry of the Monoacylglycerol Lipase (MGLL) PET Ligand [18F]T-401 and to Evaluate Fatty Acid Amide Hydrolase (FAAH) and MGLL Enzyme Availability in the Central Nervous System Using [11C]MK-3168 and [18F]T-401 PET Ligands Before and After Oral Administration of Single and Multiple Doses of CC-97489 in Healthy Adult Subjects

The purpose of this study is to evaluate enzyme availability in the central nervous system before and after CC-97489 administration in healthy participants

Start Date24 Sep 2021

Sponsor / Collaborator

Celgene Corp.

JPRN-jRCTs031180045

/ RecruitingNot ApplicableIIT

In vivo quantification of the cerebral monoacylglycerol lipase using [18F]T-401 - In vivo quantification of the cerebral monoacylglycerol lipase using [18F]T-401

Start Date03 Apr 2018

Sponsor / Collaborator-

JPRN-UMIN000031787

/ CompletedNot ApplicableIIT

In vivo quantification of the cerebral monoacylglycerol lipase using [18F]T-401 - In vivo quantification of the cerebral monoacylglycerol lipase using [18F]T-401

Start Date19 Mar 2018

Sponsor / Collaborator-

100 Clinical Results associated with [18F]T-401

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100 Translational Medicine associated with [18F]T-401

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100 Patents (Medical) associated with [18F]T-401

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100 Deals associated with [18F]T-401

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