Last update 08 May 2025

Lenalidomide/Azacitidine

Overview

Basic Info

Drug Type
Degradable Molecular Glue
Synonyms-
Target
CK1α x CRBN x DNMT1 x IFNγ x IKZF1 x IKZF3 x IL-2 x IL-6 x TNF-α
Action
inhibitors, modulators, stimulants
Mechanism
CK1α inhibitors(casein kinase 1 alpha 1 inhibitors), CRBN modulators(Cereblon modulators), DNMT1 inhibitors(DNA (cytosine-5)-methyltransferase 1 inhibitors)
+ [7]
Therapeutic Areas
NeoplasmsHemic and Lymphatic Diseases
Active Indication-
Inactive Indication
Acute Myeloid Leukemia
Originator Organization
Celgene Corp.Celgene Corp.
Active Organization-
Inactive Organization
Celgene Corp.Celgene Corp.
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC8H12N4O5
InChIKeyNMUSYJAQQFHJEW-KVTDHHQDSA-N
CAS Registry320-67-2
View All Structures (2)

Related

1
Clinical Trials associated with Lenalidomide/Azacitidine
NCT01053806
/ Unknown statusPhase 2IIT
A PHASE 2, SINGLE ARM STUDY TO DETERMINE THE SAFETY AND EFFICACY OF AZACITIDINE, AND LENALIDOMIDE IN HIGHER RISK MYELODYSPLASTIC SYNDROME
100 Clinical Results associated with Lenalidomide/Azacitidine
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100 Translational Medicine associated with Lenalidomide/Azacitidine
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100 Patents (Medical) associated with Lenalidomide/Azacitidine
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100 Deals associated with Lenalidomide/Azacitidine
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 2-
Celgene Corp.Celgene Corp.
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Approval

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Regulation

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