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Last update 08 May 2025

Securinine Nitrate

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

ACHE

Action

inhibitors

Mechanism

AChE inhibitors(Acetylcholinesterase inhibitors)

Therapeutic Areas

Infectious DiseasesNervous System DiseasesMouth and Tooth Diseases+ [1]

Active Indication

Facial ParalysisPoliomyelitis

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC13H16N2O5

InChIKeyGTMBYDCKQUSFCT-CSTPHZADSA-N

CAS Registry7104-26-9

100 Clinical Results associated with Securinine Nitrate

100 Translational Medicine associated with Securinine Nitrate

100 Patents (Medical) associated with Securinine Nitrate

116

Literatures (Medical) associated with Securinine Nitrate

03 Mar 2025·International Journal of Medical Sciences

Exploring the Shared Diagnostic Genes in IBD and Psoriasis through Bioinformatics and Experimental Assays

Article

Author: Han, Bing ; Han, Lichun ; Li, Shiquan ; Lv, Xiaodan ; Chen, Deyi ; Huang, Zhixi ; Lv, Xiaoping ; Lin, Guangfu ; Gu, Guangli ; Xu, Xiaofang ; Li, Yu

Background: Inflammatory bowel disease (IBD) is a persistent, non-specific inflammation affecting the intestines. Psoriasis is a long-lasting inflammatory disorder of the skin. There is a comorbidity correlation between IBD and psoriasis, but the specific pathogenesis of the comorbidity is unclear. Materials and methods: In this study, we analyzed datasets sourced from the Gene Expression Omnibus (GEO) database, and identified shared genes of IBD and psoriasis through differential expression analysis and weighted gene co-expression network analysis (WGCNA). Then three machine learning algorithms were applied to identify shared diagnostic genes. Next, the validation of shared diagnostic genes was evaluated with ROC curves, with the AUC determined. Subsequently, single sample gene set enrichment analysis (ssGSEA) and immune infiltration analysis were conducted. Furthermore, we obtained potential drugs such as securinine in the Drug Signature Database (DsigDB) and 7 traditional Chinese medicines in the Coremine database, which might have therapeutic effects on the comorbidity of IBD and psoriasis. Finally, we confirmed the expression of the shared diagnostic gene in colitis and psoriasis mice tissues through RT-PCR, Western blot and immunohistochemistry (IHC) methods. Results: The results showed that AQP9 had the highest diagnostic value for two diseases. AQP9 had AUC values of 93.681% for UC, 89.629% for CD,and 78.689% for psoriasis in the internal validation datasets. In the external validation datasets, AQP9 had AUC values of 90.394% for UC, 93.909% for CD,and 82.906% for psoriasis. Immune infiltration analysis and ssGSEA revealed that AQP9 might impact the disease process of IBD and psoriasis by participating in the NF-kappaB signaling pathway, and modulating immune cell differentiation. Furthermore, the expression levels of AQP9 were consistently validated, showing upregulation in IBD and downregulation in psoriasis, compared to the control group. Conclusions: This study revealed the shared diagnostic genes and potential mechanisms of the comorbidity of IBD and psoriasis, providing new directions for future research on exploring the comorbidity mechanisms and treatment targets.

01 Feb 2025·Current Organic Synthesis

Advances in the Total Synthesis of Pharmacologically Important Fused Indolizidine Alkaloids: Securinine, Gephyrotoxin and Lepadiformine

Review

Author: Loo, Jason S.E. ; Wibowo, Agustono ; Ali, Afiqah A.A. ; Mohammat, Mohd F. ; Foo, Jhi B. ; Rosli, Nor H.M.

Indolizidine alkaloids represent a diverse group of naturally occurring compounds which are derived from various sources and possess a wide range of pharmacological activities. Fused indolizidine alkaloids represent a distinct subset of these compounds, where additional rings are fused with the indolizidine core. When combined with the specific stereochemistry typically required for their biological activity, the fused ring structure complicates the synthesis of this important class of compounds. Among the well-studied fused indolizidine alkaloids are securinine, gephyrotoxin, and lepadiformine, which have all exhibited potential in important therapeutic areas. Due to their complex structures, over the years numerous approaches have been proposed to synthesize these compounds. In this article, we review the progress made in synthetic routes for these key fused indolizidine alkaloids throughout history, providing a broad overview and the distinct advantages of the various strategies that could be employed in their synthesis.

01 Jul 2024·Phytomedicine

Securinine inhibits carcinogenesis in gastric cancer by targeting AURKA-β-catenin/Akt/STAT3 and the cell cycle pathway

Article

Author: Chen, Xiaoxia ; Zhang, Huanhu ; Wang, Yun ; Kong, Luke ; Lv, Caixia ; Li, Zhiyuan ; Yang, Wenhui ; Dong, Zhuanxia ; Li, Feng ; Guo, Jianghong ; Yang, Xihua ; Yang, Mudan ; Guo, Fengtao

BACKGROUNDGastric cancer (GC) is difficult to treat with currently available treatments. Securinine (SCR) has a lengthy history of use in the treatment of disorders of the nervous system, and its anticancer potential has been gaining attention in recent years. The aim of this study was to explore the repressive effect of SCR on GC and its fundamental mechanism.METHODSThe efficacy of SCR in GC cells was detected by MTT assays. Colony formation, flow cytometry and Transwell assays were used to assess the changes in the proliferation, apoptosis, cell cycle distribution, migration and invasion of GC cells after treatment. AGS (human gastric carcinoma cell)-derived xenografts were used to observe the effect of SCR on tumor growth in vivo. The molecular mechanism of action of SCR in GC was explored via RNA sequencing, bioinformatics analysis, Western blotting, molecular docking, and immunohistochemistry.RESULTSSCR was first discovered to inhibit the proliferation, migration, and invasion of GC cells while initiating apoptosis and cell cycle arrest in vitro. It was also established that SCR has excellent anticancer effects in vivo. Interestingly, AURKA acts as a crucial target of SCR, and AURKA expression can be blocked by SCR. Moreover, this study revealed that SCR suppresses the cell cycle and the β-catenin/Akt/STAT3 pathways, which were previously reported to be regulated by AURKA.CONCLUSIONSCR exerts a notable anticancer effect on GC by targeting AURKA and blocking the cell cycle and β-catenin/Akt/STAT3 pathway. Thus, SCR is a promising pharmacological option for the treatment of GC.

100 Deals associated with Securinine Nitrate

External Link

KEGG	Wiki	ATC	Drug Bank
-	Securinine Nitrate	-	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Facial Paralysis	China	-	-
Poliomyelitis	China	-	-

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