Delving into the Latest Updates on Levorphanol Tartrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

LevoCap, LevoCap ER, Levorphanol

+ [8]

Target

μ opioid receptor

Action

agonists

Mechanism

μ opioid receptor agonists(Mu opioid receptor agonists)

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication-

Inactive Indication

Pain

Originator Organization

Bausch Health Cos., Inc.

Active Organization-

Inactive Organization

Relmada Therapeutics, Inc.

Bausch Health Cos., Inc.

Drug Highest PhaseWithdrawn

First Approval Date

United States (08 Jan 1953),

Pain

Regulation-

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Structure/Sequence

Molecular FormulaC21H33NO9

InChIKeyUMZNDVASJKIQCB-ULFFVNIPSA-N

CAS Registry5985-38-6

The purpose of this study is to determine the extent to which analgesic tolerance develops in chronic pain patients who are either started on opioids or who receive an increase in pre-study opioid dose level and then observed during long-term (20 weeks) stable opioid therapy. In addition to clinical measures of relief of ongoing chronic pain, estimation of tolerance development will be supplemented by periodic assessment of the anti-nociceptive effects of opioids using the brief thermal sensitization model.

Start Date01 Mar 2001

Sponsor / Collaborator

The University of California, San Francisco

100 Clinical Results associated with Levorphanol Tartrate

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100 Translational Medicine associated with Levorphanol Tartrate

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100 Patents (Medical) associated with Levorphanol Tartrate

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1,352

Literatures (Medical) associated with Levorphanol Tartrate

01 Feb 2025·SCIENCE OF THE TOTAL ENVIRONMENT

Characteristics and management of fecal sludge in Ethiopia with a focus on resource recovery

Article

Author: Woldeyohans, Akalu Melketsadik ; Van Hulle, Stijn W H ; Alemayehu, Esayas ; Dong, Pengyu ; Mereta, Seid Tiku ; Linnemann, Volker ; Rousseau, Diederik P L

To gain a comprehensive understanding of the potential environmental and public health implications of current fecal sludge (FS) handling practices in developing countries, investigating its composition is crucial. This study addresses quantitatively the variability of common water and wastewater parameters, parasite eggs and pollutants of concern, such as heavy metals, across different FS handling technologies. Additionally, it presents a qualitative screening of other micropollutants such as pharmaceuticals, hormones and pesticides, along with an assessment of resource recovery potential. Based on sanitation records provided by the local government, FS dislodging practices were categorized into six types (septic tanks and pits for institutions, septic tanks and pits for private houses and septic tank and pit for communal latrines). The quality of FS across these dislodging types was evaluated using 31 FS samples directly obtained from FS dislodging trucks in Ethiopia. The study found that the average moisture content of the sludge was 98.7 %, with a calorific value of 16 MJ/kg of total solids (TS), indicating its potential for water and energy recovery. Furthermore, the study revealed a prevalence ranking of Ascaris lumbricoides egg > Taenia egg > Hookworm egg> Hymenolepis nana egg> Enterobius vermicularis egg> Trichuris trichiura egg, with a mean value of 689 eggs/L of fecal sludge and a 100 % prevalence of Ascaris lumbricoides eggs. Additionally, 14 heavy metals with mean concentrations ranging between 0.002 and 6.25 mg/L were identified. For most of these metals, the concentration was significantly positively correlated with the TS content. Moreover, in this study 32 drugs and their derivatives, 6 hormones, and 1 insecticide have been detected. Overall, the compositional profile of the FS in this study indicates that improper handling of the sludge may pose potential public health and environmental threats. However, it also highlights the valuable potential of water and energy recovery from FS.

01 Sep 2024·JOURNAL OF HAZARDOUS MATERIALS

Typical emerging contaminants in sewage treatment plant effluent, and related watersheds in the Pearl River Basin: Ecological risks and source identification

Article

Author: Gu, Yilu ; Li, Min ; Yu, Yunjiang ; Fan, Mengqi ; Jia, Yujie ; Tian, Liping ; Gao, Xiaofeng ; Yu, Ying ; Liu, Siyan ; Chen, Xiaowen ; Zhu, Xiaohui ; Xiang, Mingdeng

Emerging contaminants pose a potential risk to aquatic ecosystems in the Pearl River Basin, China, owing to the high population density and active industry. This study investigated samples from eight sewage treatment plants, and five surface water bodies of related watersheds. To screen the risk of emerging contaminants (ECs), and clarify their sources, this study calculated the risk quotient of detected chemical and performed source identification/apportionment using the positive matrix factorization method. In total, 149 organic pollutants were identified. Pharmaceuticals showed significant concentrations in sewage treatment plant samples (120.87 ng/L), compared with surface water samples (1.13 ng/L). The ecological risk assessment identified three chemicals with a heightened risk to aquatic organisms: fipronil sulfide, caffeine, and roxithromycin. Four principal sources of contaminants were identified: pharmaceutical wastewater, domestic sewage, medical effluent, and agricultural runoff. Pharmaceutical wastewater was the primary contributor (60.4 %), to the cumulative EC concentration and to ECs in sewage treatment plant effluent. Agricultural drainage was the main source of ECs in surface water. This study provides a strategy to obtain comprehensive information on the aquatic risks and potential sources of EC species in areas affected by artificial activities, which is of substantial importance to pollutant management and control.

01 Sep 2024·JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

A multi-analyte assay of opioids in API and drug products using HPLC and HRMS

Article

Author: Ngo, Diem ; Geerlof-Vidavsky, Ilan ; Gryniewicz-Ruzicka, Connie ; Stark, Matthew ; Balch, Maurie

Surveillance testing is an essential component to ensuring safe, effective, and high-quality drug products are available in the commercially marketed US supply chain. Surveillance allows the agency to assess product quality and monitor for potential adulteration of drug products being used by consumers. Opioid drug products can be adulterated to enhance the effect of the intended active ingredient. Numerous accounts have been reported where fentanyl has been used as an adulterant in illicit street drugs such as heroin, cocaine, or methamphetamine. To efficiently surveil the legitimate opioid supply chain, an analytical method with the ability to simultaneously detect, identify and quantify opioid molecules is desired. In this study, a multi-opioid protocol (MOP) using liquid chromatography-high resolution mass spectrometry (HPLC-HRMS) technology was developed and validated for the detection and quantification of 27 opioid drugs. The MOP analytical procedure was applied to the analysis of drug substance and finished dosage forms. MOP was used to identify and quantify active pharmaceutical ingredients (API) listed on the label claim, and in the case of suspected economically motivated adulteration could identify and quantify undeclared opioid APIs. The analytical method analysis time was 16 minutes and the LOD and LOQ in full MS mode were (average) 0.3 and 0.8 ng/mL, respectively. The validation criteria parameters were satisfactory based on international guidelines (ICH). The MOP was successfully applied to the analysis of over 160 drug substances and finished products. For all samples tested in the study, their identities were confirmed, and assays met specifications. Overall, there was no evidence of illegal substitution or adulteration in any of the ingredients and products tested from the legitimate commercial marketed US supply chain.

100 Deals associated with Levorphanol Tartrate

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